Analysis of astrocytic function by using STOP-tetO system
| Project/Area Number |
21700419
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
TANAKA Kenji National Institute for Physiological Sciences, 分子生理研究系, 助教 (30329700)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | グリア細胞 / アストロサイト / オリゴデンドロサイト / MLC / Mlc1 / 髄鞘 / 遺伝子改変 / 脳白質 / 脳梁 / 髄鞘形成 / 多機能遺伝子改変 |
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| Research Abstract |
I succeeded to establish the animal model for a white matter disease named megalencephalic leukoencephalopathy with subcortical cysts (MLC), which is caused by MLC1 mutation. I used a versatile new gene modulation system to generate both mouse Mlc1 gene conditional knockout and overexpression. I found that Mlc1 was exclusively expressed by astrocytes and its overexpression resulted in astrocytic swelling and vacuolating myelopathy, whereas Mlc1 gene knockout mice were grossly normal.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Mice with altered myelin proteolipid protein gene expression display cognitive deficits accompanied by abnormal neuron-glia interactions and decreased conduction velocities2009
Author(s)
Tanaka H, Ma J, Tanaka KF, Takao K, Komada K, Suzuki A, Ishibashi T, Baba H, Isa T, Shigemoto R, Ono K, Miyakawa T, Ikenaka K.
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Journal Title
J Neurosci 29
Pages: 8363-8371
Related Report
Peer Reviewed
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