Elucidation of the novel mechanisms which modulate L-glutamate transporters
| Project/Area Number |
21700422
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
SATO Kaoru 国立医薬品食品衛生研究所, 薬理部第一室, 室長 (10311391)
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | グリア細胞 / グルタミン酸トランスポーター / L-Glu トランスポーター / アストロサイト / Xenopus oocyte / syntaxin / EAAT2 / PUFA / docosahexaic acid / L-Gluトランスポーター / タンパク質相互作用 / V5 / L-gluトランスポーター / PIP2 / PI4キナーゼ / 蛋白質相互作用 / アフリカツメがエル卵母細胞 / 翻訳後修飾 / トランスポーター電流 / NSAIDs / EAAT1 |
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| Research Abstract |
We clarified that Nitric oxide inhibits glial L-glutamate transporter function, GLAST and GLT1, through S-nitrosylation using cultured astrocytes and Xenopus oocyte overexpressing these transporters. We further found that docosahexaic acid enhanced L-glutamate transporter function.
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Report
(5 results)
Research Products
(131 results)
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[Journal Article] In vitro blood-brain barrier models using brain capillary endothelial cells isolated from infant and adult rats retain age-related barrier properties2013
Author(s)
Takata, F., Dohgu, S., Yamauchi, A., Matsumoto, J., Machida, T., Fujishita, K., Shibata, K., Shinozaki, Y., Sato, K., Kataoka, Y., Koizumi, S.
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Journal Title
Related Report
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[Journal Article] Cell-autonomous enhancement of glutamate-uptake by female astrocytes2012
Author(s)
Morizawa, Y, Sato, K., Takaki, J., Kawasaki, A., Shibata, K., Suzuki, T., Ohta, S., Koizumi, S
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Journal Title
Cell Mol Neurobiol
Volume: 32 (6)
Pages: 953-6
Related Report
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[Journal Article] Discovery of a tamoxifen-related compound that suppresses glial L-glutamate transport activity without Interaction with estrogen receptors2012
Author(s)
Sato, K., Kuriwaki J., Takahashi, K., Saito, Y., Oka, J., Otani, Y., Sha, Y., Nakazawa, K., Sekino, Y., Ohwada, T.
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Journal Title
ACS Chem Neurosci
Volume: 3 (2)
Pages: 105-113
Related Report
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[Journal Article] Discovery of a tamoxifen-related compound that suppresses glial L-glutamate transport activity without interaction with estrogen receptors2012
Author(s)
Sato, K., Kuriwaki, J., Takahashi, K., Saito, Y., Oka, J., Otani, Y., Sha, Y., Nakazawa, K., Sekino, Y., Ohwada, T.(C.A.)
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Journal Title
ACS Chem Neurosci
Volume: 3
Pages: 105-113
Related Report
Peer Reviewed
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[Journal Article] Two NSAIDs, niflumic acid and diclofenac, inhibit the human glutamate transporter EAAT1 through different mechanisms2010
Author(s)
Takahashi, K., Ishii-Nozawa, R., Takeuchi, K., Nakazawa, K., Sato, K.
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Journal Title
J Pharmacol Sci
Volume: 112
Pages: 113-117
Related Report
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[Journal Article] Cell-autonomous enhancement of glutamate-uptake by female astrocytes
Author(s)
Morizawa, Y., Sato, K., Takaki, J., Kawasaki, A., Shibata, K., Suzuki, T., Ohta, S., Koizumi, S.
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Journal Title
Cell Mol Neurobiol
Volume: (In press)
Related Report
Peer Reviewed
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[Presentation] Effects of carbon nanotubes on proliferation of neural stem cells and microglial viability2012
Author(s)
Shigemoto-Mogami, Y., Fujimori, K., Igarashi, Y., Hirose, A., Sekino Y., Sato, K.
Organizer
第35回 日本神経科学大会
Place of Presentation
名古屋市
Related Report
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[Presentation] Search for genetic markers for risks in emotion and social interaction caused by exposure to chemical compounds in embryonic or neonatal periods2012
Author(s)
Oguchi-Katayama, A., Monma, A., Otomo, Y., Imai, M., Akitomo, T., Takahashi, Y., Kato, F., Sekino, Y., Sato, K.
Organizer
第35回 日本神経科学大会
Place of Presentation
名古屋市
Related Report
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[Presentation] The Clonal difference in response to L-glutamate and ATP of human induced pluripotent stem cell-derived neurons2012
Author(s)
Sato, K., Takahashi, K., Shigemoto-Mogami, Y., Ohtsu, K., Okada, Y., Okano, H., Sekino, Y.
Organizer
第35回 日本神経科学大会
Place of Presentation
名古屋市
Related Report
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[Presentation] Paroxetine Prevents the Functional Impairment of L-Glutamate Transporters in Inflammation by Modulating Microglial Glutamate Release2012
Author(s)
Sato, K., Fujimori, K., Takaki, J., Suzuki, T., Sekino, Y
Organizer
SfN 2012
Place of Presentation
New Orleans, USA
Related Report
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[Presentation] The comparative study of the mRNA-expression of P2 receptors and glutamate receptors between neurons differentiated from 201B7 and 253G1 human induced pluripotent stem cell lines2012
Author(s)
Sato, K., Takahashi, K., Shigemoto-Mogami, Y., Ohtsu, K., Okada, Y., Okano, Y., Sekino, Y
Organizer
the 11^<th> biennial meeting of APSN and the 55th annual meeting of JSN
Place of Presentation
Kobe, Japan
Related Report
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[Presentation] The clonal difference in response to ATP and L-Glutamate of human induced pluripotent stem cell-derived neurons2012
Author(s)
Sekino, Y, Takahashi, K., Shigemoto-Mogami, Y., Ohtsu, K., Okada, Y., Okano, Y, Sato, K.
Organizer
The 11^<th> biennial meeting of APSN and the 55^<th> annual meeting of JSN
Place of Presentation
Kobe, Japan
Related Report
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[Presentation] Discovery of a tamoxifen-related compound that suppresses glial L-glutamate transport activity without interaction with estrogen receptors2012
Author(s)
Sato, K., Kuriwaki, J., Takahashi, K., Saito, Y., Oka, J., Otani, Y., Sha, Y., Nakazawa K., Sekino, Y., Ohwada, T.
Organizer
FENS meeting 2012
Place of Presentation
Barcelona, Spain
Related Report
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[Presentation] Electrophysiological and transcriptomic identification of the remote influence in the central amygdala following single postnatal administration of valproate in rats2012
Author(s)
Takahashi, Y, Katayama, A., Nagase, M., Moriguchi, T., Sato, K., Kato, F.
Organizer
FENS meeting 2012
Place of Presentation
Barcelona, Spain
Related Report
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[Presentation] The clonal difference in response to ATP of human induced pluripotent stem cell-derived neurons2012
Author(s)
Sato, K., Takahashi, K., Shigemoto-Mogami, Y., Ohtsu, K., Okada, Y., Okano, H., Sekino, Y.
Organizer
ISSCR2012
Place of Presentation
Yokohama, Japan
Related Report
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[Presentation] The clonal difference in response to ATP of human induced pluripotent stem cell-derived neurons2012
Author(s)
Sato, K., Takahashi, K., Shigemoto-Mogami, Y., Ohtsu, K., Okada, Y., Okano, H., Sekino, Y
Organizer
Purine2012
Place of Presentation
Fukuoka, Japan
Related Report
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[Presentation] Down-regulation of astrocyte L-glu transporters under inflammation is caused by glia-glial communication2011
Author(s)
Sato, K., Takaki, J., Fujimori, K., Suzuki, T., Sekino, Y.
Organizer
SfN2011
Place of Presentation
Washington D.C., USA
Related Report
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[Presentation] Neuropharmacological effects of fullerene derivatives2009
Author(s)
Suzuki T, Takaki J, Kamiya Y, Nakamura Y, Mashino T, Sato K, Nakazawa K, Takahashi T, Haruyama A, Mori K, Iwai T, Oka J-I
Organizer
SFN2009
Place of Presentation
米国シカゴ市
Year and Date
2009-10-21
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