| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
Point mutation of different alternative splicing axon of milton gene, required for the anterograde transport of mitochondria, indicated the different phenotype such as axon degeneration or abnormal neurite outgrowth. Expressing single milton isoforms was sufficient to rescue the mutant phenotype. This result indicated that multiple isoforms were anticipated in the maintenance of neuronal axon. Although both mutant neurons failed to target mitochondria to their terminals, abnormal mitochondria transport was not sufficient to cause axon degeneration.
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