The role of molecular diversity of milton gene for the maintenance of neuronal axon
| Project/Area Number |
21700424
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Shinshu University |
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Principal Investigator |
YONEKURA Shinichi Shinshu University, 農学部, 助教 (40443113)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 神経科学 / 軸索 / スプライシング / ミトコンドリア / アイソフォーム / 分子多様性 |
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| Research Abstract |
Point mutation of different alternative splicing axon of milton gene, required for the anterograde transport of mitochondria, indicated the different phenotype such as axon degeneration or abnormal neurite outgrowth. Expressing single milton isoforms was sufficient to rescue the mutant phenotype. This result indicated that multiple isoforms were anticipated in the maintenance of neuronal axon. Although both mutant neurons failed to target mitochondria to their terminals, abnormal mitochondria transport was not sufficient to cause axon degeneration.
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Report
(3 results)
Research Products
(6 results)
