Analysis of molecular mechanism of neuron-glia interaction in long-term memory formation
| Project/Area Number |
21700425
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | 財団法人東京都医学研究機構 (2010)
Tokyo Metropolitan Organization for Medical Research (2009) |
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Principal Investigator |
MATSUNO Motomi 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 研究員 (90392365)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | グリア細胞 / 脳神経 / 神経科学 / ショウジョウバエ / ショウジョウバェ |
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| Research Abstract |
Recent studies suggest that glias are implicated in synapse formation and plasticity through neuron-glia interaction. However, how they contribute to the long-lasting memory is not clear. Previously we found that training-dependent increase in Drosophila Klingon (Klg), a homophilic cell adhesion molecule, is required for long-term memory (LTM) formation. In this study we purposed to elucidate the function of neuron-glia interaction in LTM formation through the functional analysis of Klg. Klg protein was expressed in both neurons and glia, and a training-dependent increase in neuron-glia interactions mediated by Klg was required to form LTM. Furthermore, we identified that neuron-glia interactions via Klg modulate glial-gene expression required for LTM formation.
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Report
(3 results)
Research Products
(8 results)
