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Analysis of the reactivation of food-odor evoked activity in the olfactory cortex

Research Project

Project/Area Number 21700429
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neurophysiology and muscle physiology
Research InstitutionThe University of Tokyo

Principal Investigator

MANABE Hiroyuki  The University of Tokyo, 大学院・医学系研究科, 特任研究員 (80511386)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords神経科学 / 嗅覚 / 電気生理 / 睡眠 / 嗅皮質 / 鋭波 / sharp wave
Research Abstract

The olfactory cortex is functionally isolated from the external odor world during slow-wave sleep. However, the neuronal activity pattern in the olfactory cortex and its functional role during slow-wave sleep were not well understood. Here, I demonstrated in freely behaving rats that the anterior piriform cortex repeatedly generated sharp waves accompanied by synchronized discharges of numerous cortical neurons during slow-wave sleep. The olfactory cortex sharp waves drove synchronized top-down inputs to the olfactory bulb. The olfactory cortex sharp waves may represent the reactivation of the neuronal activation pattern during preceding waking period and contribute to the memory consolidation process in the olfactory cortex.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (7 results)

All 2011 2010

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (6 results)

  • [Journal Article] Olfactory Cortex Generates Synchronized Top-Down Inputs to the Olfactory Bulb during Slow-Wave Sleep2011

    • Author(s)
      Hiroyuki Manabe, Ikue Kusumoto-Yoshida, Mizuho Ota, Kensaku Mori
    • Journal Title

      Journal of Neuroscience 31(22)

      Pages: 8123-8133

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] Olfactory cortex generates sharp waves that drive synchronized inputs to the granule cells in the olfactory bulb during slow-wave sleep2010

    • Author(s)
      Hiroyuki Manabe, Ikue Kusumoto-Yoshida, Mizuho Ota, Kensaku Mori
    • Organizer
      Neuroscience2010
    • Place of Presentation
      サンディエゴコンベンションセンター(米国サンディエゴ)
    • Year and Date
      2010-11-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Olfactory cortex generates sharp waves that drive synchronized input to the granule cells in the olfactory bulb during slow-wave sleep2010

    • Author(s)
      眞部寛之
    • Organizer
      Neuroscience 2010
    • Place of Presentation
      サンディエゴコンベンションセンター(米国 サンディエゴ)
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Olfactory cortex sharp waves during slow-wave sleep2010

    • Author(s)
      Hiroyuki Manabe, Ikue Kusumoto-Yoshida, Mizuho Ota, Kensaku Mori
    • Organizer
      第8回国際シンポジウム「味覚嗅覚の分子神経機構」
    • Place of Presentation
      九州大学馬出キャンパス(福岡県福岡市)
    • Year and Date
      2010-11-07
    • Related Report
      2010 Final Research Report
  • [Presentation] Olfactory cortex sharp waves during slow-wave sleep2010

    • Author(s)
      眞部寛之
    • Organizer
      第8回国際シンポジウム「味覚嗅覚の分子神経機構」
    • Place of Presentation
      九州大学馬出キャンパス(福岡県 福岡市)
    • Year and Date
      2010-11-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Neuronal circuits responsible for the generation of olfactory cortex and olfactory bulb sharp waves during slow-wave sleep2010

    • Author(s)
      Hiroyuki Manabe, Ikue Kusumoto-Yoshida, Mizuho Ota, Kensaku Mori
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市)
    • Year and Date
      2010-09-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Neuronal circuits responsible for the generation of olfactory cortex and olfactory bulb sharp waves during slow-wave sleep2010

    • Author(s)
      眞部寛之
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸コンベンションセンター(兵庫県 神戸)
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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