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Neural basis for the control of visual fixation and eye movements by the frontal eye field and the superior colliculus

Research Project

Project/Area Number 21700430
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neurophysiology and muscle physiology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

IZAWA Yoshiko  東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (40372453)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords姿勢・運動制御 / 前頭眼野 / 上丘 / 注視 / サッケード / 滑動性眼球運動 / オムニポーズニューロン
Research Abstract

Functionally, the suppression of eye movements is essential during visual fixation to hold the image of the target on the fovea(selective attention). In the present study, we identified a localized area in the monkey frontal eye field(FEF) at which electrical stimulation induced suppression of the initiation of saccades bilaterally at low thresholds. This area was also associated with the suppressive effect of stimulation on smooth pursuit eye movements, suggesting that the suppressive control of saccades and pursuit may be exerted by a common neuronal assembly in the FEF.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (39 results)

All 2012 2011 2010 2009

All Journal Article (7 results) (of which Peer Reviewed: 6 results) Presentation (30 results) Book (2 results)

  • [Journal Article] Suppression of smooth pursuit eye movements induced by electrical stimulation of the monkey frontal eye field2011

    • Author(s)
      Izawa Y, Suzuki H, and Shinoda Y
    • Journal Title

      J. Neurophysiol

      Volume: 106 Pages: 2675-2687

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neural substrate for suppression of omnipause neurons at the onset of saccades2011

    • Author(s)
      Shinoda Y, Sugiuchi Y, Takahashi M, and Izawa Y
    • Journal Title

      Ann. N. Y. Acad. Sci

      Volume: 1233 Pages: 100-106

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of smooth pursuit eye movements induced by electrical stimulation of the monkey frontal eye field2011

    • Author(s)
      Izawa, Y., Suzuki, H., Shinoda, Y.
    • Journal Title

      J.Neurophysiol.

      Volume: 106 Issue: 5 Pages: 2675-2687

    • DOI

      10.1152/jn.00182.2011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neural substrate for suppression of omnipause neurons at the onset of saccades2011

    • Author(s)
      Shinoda, Y., Sugiuchi, Y., Takahashi, M., Izawa, Y.
    • Journal Title

      Ann.N.Y.Acad.Sci.

      Volume: 1233 Issue: 1 Pages: 100-106

    • DOI

      10.1111/j.1749-6632.2011.06171.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 垂直性サッケードの神経回路:上丘から上斜筋運動ニューロンに至る経路2010

    • Author(s)
      伊澤佳子、杉内友理子、篠田義一
    • Journal Title

      日本眼科学会雑誌

      Volume: 114 Pages: 389-389

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] Response properties of fixation neurons and their location in the frontal eye field in the monkey2009

    • Author(s)
      Izawa Y, Suzuki H, and Shinoda Y
    • Journal Title

      J. Neurophysiol

      Volume: 102 Pages: 2410-2422

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Response properties of fixation neurons and their location in the frontal eye field in the monkey2009

    • Author(s)
      Izawa Y, Suzuki H, Shinoda Y
    • Journal Title

      Journal of neurophysiology 102

      Pages: 2410-22

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 抑制から見たサッケード系と滑動性眼球運動系2012

    • Author(s)
      伊澤佳子、鈴木寿夫、篠田義一
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本
    • Year and Date
      2012-03-31
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Contribution of the frontal eye field to suppressive control of saccades and smooth pursuit eye movements in monkeys2012

    • Author(s)
      Izawa, Y., Suzuki, H., Shinoda, Y.
    • Organizer
      Frontiers in primate neuroscience researches
    • Place of Presentation
      Tokyo
    • Year and Date
      2012-02-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Contribution of the frontal eye field to suppressive control of saccades and smooth pursuit eye movements in monkeys2012

    • Author(s)
      Izawa Y, Suzuki H, and Shinoda Y
    • Organizer
      Frontiers in primaten euroscience researches
    • Place of Presentation
      Tokyo
    • Related Report
      2011 Final Research Report
  • [Presentation] 前頭眼野による滑動性眼球運動の抑制2011

    • Author(s)
      伊渾佳子、鈴木寿夫、篠田義一
    • Organizer
      包括型脳科学研究推進支援ネットワーク夏のワークショップ
    • Place of Presentation
      神戸
    • Year and Date
      2011-08-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Suppression of smooth pursuit eye movements by the frontal eye field in the monkey2011

    • Author(s)
      Izawa, Y., Suzuki, H., Shinoda, Y.
    • Organizer
      The Gordon Research Conference 2011 on Eye Movements
    • Place of Presentation
      Maine, U.S.A.
    • Year and Date
      2011-08-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Neural circuits for vertical saccades and their similarity to the vestibulo-oculomotor system2011

    • Author(s)
      Sugiuchi, Y., Takahashi, M., Izawa, Y., Shinoda, Y.
    • Organizer
      The Gordon Research Conference 2011 on Eye Movements
    • Place of Presentation
      Maine, U.S.A.
    • Year and Date
      2011-08-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 前頭眼野系によるサッケードおよび滑動性眼球運動の制御2011

    • Author(s)
      伊澤佳子
    • Organizer
      生理学研究所研究会「行動制御における脳領域間の機能連関」
    • Place of Presentation
      愛知県岡崎市生理学研究所
    • Year and Date
      2011-01-08
    • Related Report
      2011 Final Research Report
  • [Presentation] Suppression of smooth pursuit eye movements by the frontal eye field in the monkey2011

    • Author(s)
      Izawa Y, Suzuki H, and Shinoda Y
    • Organizer
      The Gordon Research Conference 2011 on Eye Movements, University of New England
    • Place of Presentation
      Biddeford, Maine, U. S. A.
    • Related Report
      2011 Final Research Report
  • [Presentation] Neural circuits for vertical saccades and their similarity to the vestibulo-oculomotor system2011

    • Author(s)
      Sugiuchi Y, Takahashi M, Izawa Y, and Shinoda Y
    • Organizer
      The Gordon Research Conference 2011 on Eye Movements, University of New England
    • Place of Presentation
      Biddeford, Maine, U. S. A.
    • Related Report
      2011 Final Research Report
  • [Presentation] 垂直性サッケードと水平性サッケード生成に関わる神経回路の相同性2011

    • Author(s)
      杉内友理子、高橋真有、伊澤佳子、篠田義一
    • Organizer
      第70回日本めまい平衡医学会総会
    • Place of Presentation
      千葉
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 前頭眼野による滑動性眼球運動の抑制2011

    • Author(s)
      伊澤佳子、鈴木寿夫、篠田義一
    • Organizer
      包括型脳科学研究推進支援ネットワーク夏のワークショップ
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2011 Final Research Report
  • [Presentation] Suppressive effects of electrical stimulation of the frontal eye field on smooth pursuit eye movements in the monkey2010

    • Author(s)
      Izawa Y, Suzuki H, and Shinoda Y
    • Organizer
      The 33rd Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Kobe
    • Year and Date
      2010-09-02
    • Related Report
      2011 Final Research Report
  • [Presentation] Suppressive effects of electrical stimulation of the frontal eye field on smooth pursuit eye movements in the monkey.2010

    • Author(s)
      Izawa, Y., Suzuki, H., Shinoda, Y.
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 前頭眼野による急速眼球運動および滑動性眼球運動の抑制2010

    • Author(s)
      伊澤佳子
    • Organizer
      第4回生理学研究所Motor Control研究会
    • Place of Presentation
      岡崎(愛知県)
    • Year and Date
      2010-05-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] サッケード抑制に関わるサル前頭眼野注視ニューロンの活動2010

    • Author(s)
      伊澤佳子、鈴木寿夫、篠田義一
    • Organizer
      第69回日本めまい平衡医学会総会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 前頭眼野による急速眼球運動および滑動性眼球運動の抑制2010

    • Author(s)
      伊澤佳子
    • Organizer
      第4回生理学研究所Motor Control研究会
    • Place of Presentation
      岡崎
    • Related Report
      2011 Final Research Report
  • [Presentation] カハル間質核細胞の入出力機構2009

    • Author(s)
      杉内友理子, 伊澤佳子, 高橋真有, 篠田義一
    • Organizer
      第68回日本めまい平衡医学会総会
    • Place of Presentation
      徳島
    • Year and Date
      2009-11-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Neural organization of saccade generation and suppression2009

    • Author(s)
      伊澤佳子
    • Organizer
      International symposium : New perspectives on neural mechanisms of cognition and action
    • Place of Presentation
      Machida
    • Year and Date
      2009-11-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Suppression of saccades and response properties of fixation neurons in the monkey frontal eye field2009

    • Author(s)
      伊澤佳子, 鈴木寿夫, 篠田義一
    • Organizer
      Neuroscinece 2009
    • Place of Presentation
      Nagoya
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Properties of input-output organization of INC neurons as a counterpart of IBNs in the horizontal saccade system2009

    • Author(s)
      杉内友理子, 伊澤佳子, 高橋真有, 篠田義一
    • Organizer
      Neuroscinece 2009
    • Place of Presentation
      Nagoya
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] サル前頭眼野注視ニューロンの活動とサッケードの抑制2009

    • Author(s)
      伊澤佳子
    • Organizer
      第3回生理学研究所Motor Control研究会
    • Place of Presentation
      岡崎
    • Year and Date
      2009-05-29
    • Related Report
      2011 Final Research Report
  • [Presentation] サル前頭眼野注視ニューロンの活動とサッケードの抑制2009

    • Author(s)
      伊澤佳子, 鈴木寿夫, 篠田義一
    • Organizer
      第3回生理学研究所 Motor Control 研究会
    • Place of Presentation
      岡崎
    • Year and Date
      2009-05-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] Response properties of fixation neurons in the frontal eye field in the monkey2009

    • Author(s)
      伊澤佳子, 鈴木寿夫, 篠田義一
    • Organizer
      Eye Movements and Vision, A Symposium in Honor of Fred Miles
    • Place of Presentation
      Oxford, UK
    • Year and Date
      2009-04-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] Input-output organization of INC neurons in the pathway from the superior colliculus to trochlear motoneurons2009

    • Author(s)
      杉内友理子, 伊澤佳子, 高橋真有, 篠田義一
    • Organizer
      Eye Movements and Vision, A Symposium in Honor of Fred Miles
    • Place of Presentation
      Oxford, UK
    • Year and Date
      2009-04-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] Neural organization of saccade generation and suppression2009

    • Author(s)
      Izawa Y, Suzuki H, and Shinoda Y
    • Organizer
      International symposium : New perspectives on neural mechanisms of cognition and action
    • Place of Presentation
      Tamagawa University, Machida
    • Related Report
      2011 Final Research Report
  • [Presentation] Response properties of fixation neurons in the frontal eye field in the monkey, Eye Movements and Vision2009

    • Author(s)
      Izawa Y, Suzuki H, and Shinoda Y
    • Organizer
      A Symposium in Honor of Fred Miles
    • Place of Presentation
      Oxford, UK
    • Related Report
      2011 Final Research Report
  • [Presentation] Input-output organization of INC neurons in the pathway from the superior colliculus to trochlear motoneurons, Eye Movements and Vision2009

    • Author(s)
      Sugiuchi Y, Izawa Y, Takahashi M, and Shinoda Y
    • Organizer
      A Symposium in Honor of Fred Miles
    • Place of Presentation
      Oxford, UK
    • Related Report
      2011 Final Research Report
  • [Presentation] Suppression of saccades and response properties of fixation neurons in the monkey frontal eye field2009

    • Author(s)
      Izawa Y, Suzuki H, and Shinoda Y
    • Organizer
      The 32nd Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Nagoya
    • Related Report
      2011 Final Research Report
  • [Presentation] Properties of input-outputorganization of INC neurons as a counterpart of IBNs in the horizontal saccade system2009

    • Author(s)
      Sugiuchi Y, Izawa Y, Takahashi M, and Shinoda Y
    • Organizer
      The 32nd Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Nagoya
    • Related Report
      2011 Final Research Report
  • [Presentation] カハル間質核細胞の入出力機構2009

    • Author(s)
      杉内友理子、伊澤佳子、高橋真有、篠田義一
    • Organizer
      第68回日本めまい平衡医学会総会
    • Place of Presentation
      〓島
    • Related Report
      2011 Final Research Report
  • [Book] めまいと平衡障害、内野善生・古屋信彦編2009

    • Author(s)
      伊澤佳子、前頭眼野
    • Publisher
      金原出版
    • Related Report
      2011 Final Research Report
  • [Book] めまいと平衡障害2009

    • Author(s)
      伊澤佳子
    • Publisher
      金原出版
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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