| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
Neurons in nucleus laminaris (NL) of birds detect the coincidence of binaural excitatory inputs and process interaural time differences (ITDs) for sound localization. In this study, we found a feed-forward inhibition that follows the EPSCs from ipsilateral cochlear nucleus after a short time delay (1-2 ms). These IPSCs were observed in the low frequency NL neurons and likely mediated by GABA-positive interneurons, which distributed in and near the low frequency NL region. Model simulations demonstrate that phasic IPSCs narrowed a time window of coincidence detection and increased the ITD sensitivity during a low-level of excitatory inputs. We concluded that the complementary interaction between the feed-forward and feedback inhibitions effectively increased the ITD sensitivity over a wide range of sound levels in low frequency NL neurons.
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