| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
|
|---|
| Research Abstract |
It is known that production of nitric oxide (NO) is enhanced in injured motoneurons after peripheral nerve injury, The enhanced NO production is thought to contribute to the occurrence of nerve paralysis, However, it remains unknown how the enhanced NO production induces nerve paralysis, In this study, I focused on the changes in the membrane excitability by NO as the mechanism of neural paralysis, In particular, I studied on the NO-mediated modulation of leak K^+ currents, which regulate the resting membrane potential and the input resistance, Following application of 8-Br-cGMP, leak K^+ currents were decreased in large-sized motoneurons, while those were increased in small-sized motoneurons, These results suggest that activation of NO-cGMP-PKG pathway alters the membrane excitability of motoneurons through modulating the leak K^+ currents, It is possible that such neural mechanisms are involved in the occurrence of neural paralysis,
|
