Connection Specificity in Cortical Circuits

• Project/Area Number: 21700438
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neurophysiology and muscle physiology
• Research Institution: National Institute for Physiological Sciences
• Principal Investigator: OTSUKA Takeshi National Institute for Physiological Sciences, 大脳皮質機能研究系, 助教 (10390692)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 大脳皮質 / 錐体細胞 / 介在細胞 / FS細胞 / マルティノッティ細胞 / マルティノッチ細胞

Research Abstract

I investigated how inhibitory interneurons are incorporated into excitatory subnetworks in cortical circuits to understand information processing of the cortex. Whole-cell recordings were obtained from layer 5 (L5) pyramidal cells and inhibitory interneruons in rat frontal cortical slices. I examined connection specificity between pyramidal cells and inhibitory interneurons. My results suggest that L5 interneurons form distinct intralaminar and interlaminar subnetworks with pyramidal cells, depending on inhibitory cell types.

Research Products

• [Journal Article] Cell diversity and connection specificity between callosal projection neurons in the frontal cortex. (2011)
  • Author(s): 大塚岳、川口泰雄
  • Journal Title: J Neurosci. Vol.31 Pages: 3862-3870
  • Peer Reviewed
• [Journal Article] Cell diversity and connection specificity between callosal projection neurons in the frontal cortex (2011)
  • Author(s): 大塚岳、川口泰雄
  • Journal Title: Journal of Neuroscience Volume: 31 Pages: 3862-3870
  • Peer Reviewed
• [Journal Article] Cortical Inhibitory cell types differentially form intralaminar and interlaminar subnetworks with excitatory neurons. (2009)
  • Author(s): 大塚岳、川口泰雄
  • Journal Title: J.Neurosci. Vol.29 Pages: 10533-10540
  • Peer Reviewed
• [Journal Article] Cortical Inhibitory Cell Types Differentially Form Intralaminar and Interlaminar Subnetworks with Excitatory Neurons (2009)
  • Author(s): 大塚岳、川口泰雄
  • Journal Title: Journal of Neuroscience 29 Pages: 10533-10540
  • Peer Reviewed
• [Presentation] 前頭皮質における交連性投射ニューロンの性質と結合特異性 (2010)
  • Organizer: 日本神経科学大会
  • Place of Presentation: 神戸国際会議場(兵庫県)
• [Presentation] Cell diversity and connections between callosal projection neurons in the frontal cortex (2010)
  • Organizer: 4th International Neural Microcircuitry Conference
  • Place of Presentation: カヌチャリゾート(沖縄)
• [Presentation] 大脳皮質の抑制性介在細胞タイプに依存した結合特異性 (2009)
  • Organizer: 日本神経科学大会
  • Place of Presentation: 名古屋国際会議場(愛知県)
• [Remarks] ホームページ等
• [Remarks] 部門ホームページ
  • URL: http://www.nips.ac.jp/circuit/
• [Remarks]
  • URL: http://www.nips.ac.jp/contents/release/entry/2009/08/post-27.html