Left-right asymmetry of mouse hippocampal functions

• Project/Area Number: 21700440
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neurophysiology and muscle physiology
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: SHINOHARA Yoshiaki The Institute of Physical and Chemical Research, 平瀬研究ユニット, 基礎科学特別研究員 (10425423)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 脳の左右差 / 海馬 / 哺乳類 / 生理学 / 形態学 / 神経回路 / 解剖学

Research Abstract

We reported better performance of right hippocampus than left in spatial memory task in mice. Next, we found that ipsilateral/ contralateral ratios of CA3-CA1 axonal innervations are dependent on the locations (i.e. layer in CA1) of the synapse (submitted). We are now analyzing left-right differences of hippocampal electrophysiological activities in vivo.

Research Products

• [Journal Article] Right-hemispheric dominance of spatial memory in split-brain mice. (2010)
  • Author(s): Shinohara Y, Hosoya A, Yamasaki N, Ahmed H, Hattori S, Eguchi M, Yamaguchi S, Miyakawa T, Hirase H, Shigemoto R.
  • Journal Title: Hippocampus
  • Peer Reviewed
• [Journal Article] Size and receptor densities of glutamatergic synapses: A viewpoint of left-right asymmetry of CA3-CA1 connections.(両名ともcorresonding author*)on line journal (2009)
  • Author(s): Shinohara Y, Hirase H
  • Journal Title: Front Neuroanat. 3 Pages: 10-10
  • Peer Reviewed
• [Journal Article] シナプスレベルから見た脳の左右非対称性 (2009)
  • Author(s): Shinohara Y
  • Journal Title: 生化学 Pages: 806-811
  • Peer Reviewed
• [Journal Article] Quantification of postsynaptic density proteins : glutamate receptor subunits and scaffolding proteins
  • Author(s): 篠原良章
  • Journal Title: Hippocampus Volume: (in press)
  • Peer Reviewed
• [Journal Article] Right-hemispheric dominance of spatial memory in split-brain mice
  • Author(s): 篠原良章
  • Journal Title: Hippocampus Volume: (in press)
  • Peer Reviewed
• [Presentation] Effect of the stimulation of peduncolopontine tegmentum, basal forebrain or reticular ascending system on the activity of the neocortex, hippocampus and thalamus (2010)
  • Author(s): Pignatelli M., Shinohara Y., Takata N., Leinekugel X., Rockland K.S., Hirase H
  • Organizer: FENS
  • Place of Presentation: アムステルダム
  • Year and Date: 2010-07-06
• [Presentation] Left-right asymmetry of hippocampal pyramidal synapses (2009)
  • Author(s): Shinohara Y, Hirase H, Shigemoto R
  • Organizer: 第36回国際生理学会
  • Place of Presentation: 京都
  • Year and Date: 2009-07-29
• [Book] 岩波「科学」(「マウス錐体細胞シナプスの左右差」) (2009)
  • Author(s): 篠原良章, 重本隆一
• [Remarks] ホームページ等
• [Remarks] ラボのウェブサイトの業績リスト
  • URL: http://www.brain.riken.jp/labs/hirase/more.html
• [Remarks] 岩波書店「科学」のバックナンバー
  • URL: http://www.iwanami.co.jp/kagaku/