Protei n anchoring-therapy indefectof extra cellar matrix at skeIeta muscle
Project/Area Number |
21700443
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Neurophysiology and muscle physiology
|
Research Institution | Nagoya University |
Principal Investigator |
ITO Mikako 名古屋大学, 大学院・医学系研究科, 助教 (60444402)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 先天性筋無力症 / 遺伝子治療 / collagen Q / アセチルコリンエステラーゼ欠損症 / 分子欠損症 / 先天性筋無力症候群 / AChE欠損症 |
Research Abstract |
Congenital defects of ColQ cause endplate AChE deficiency and myasthenic syndrome. The intravenous administration of adeno-associated virus COLQto Colq-/-mice recovers motor functions, synaptic transmission, as well as the morphology of the NMJ. ColQ-tailed AChE is specifically anchored to NMJ. Furthermore, the in vivo injection of recombinant ColQ-tailed AChE protein complex into the gluteus maximus muscle of Colq-l- mice led to accumulation of AChE in non-injected forelimbs. We demonstrated for the first time in vivo that the ColQ protein contains a tissue-targeting signal that is sufficient for anchoring itself to the NMJ.
|
Report
(3 results)
Research Products
(28 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease.2009
Author(s)
Fu Y, Ito M, Fujita Y, Ito M, Ichihara M, Masuda A, Suzuki Y, Maesawa S, Kajita Y, Hirayama M, Ohsawa I, Ohta S, Ohno K.
-
Journal Title
Neuroscience Letters
Volume: 453
Pages: 81-85
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-