Research on optimization of bone-implant stability, development of bubble like scaffold

• Project/Area Number: 21700461
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Niigata University
• Principal Investigator: MATSUDA JUNPEI Niigata University, ベンチャー・ビジネス・ラボラトリー研究機関, 研究員 (00535271)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 生体工学 / 生体材料 / バイオメカニクス / 再生医療 / 細胞・組織 / バイオエンジニアリング

Research Abstract

In order to improve the bone inductivity of bone and implant, we developed free-shaped bubble like scaffold. The ingredient of scaffold is collagen and propylene glycol alginate. The survival rate of osteoblast was no significant as compared with control group. Furthermore, ALP activity accelerated. The volume share of scaffold was 27 compared with the volume of only collagen.

Research Products

• [Journal Article] 海綿骨の定量的圧縮に対する骨梁変形と石灰化度との関係 (2011)
  • Author(s): 松田純平, 原利昭, 遠藤直人
  • Journal Title: 骨形態計測誌 Volume: (in press)
  • Peer Reviewed
• [Journal Article] 圧縮荷重下の海綿骨骨梁変形と骨密度分布の関係 (2010)
  • Author(s): 松田純平, 原利昭, 遠藤直人
  • Journal Title: 日本骨形態計測学会誌 Vol.21 in press
• [Presentation] 軟骨下骨および軟骨下骨プレートに対する変形性関節症の影響 (2011)
  • Author(s): 松田純平, 目良恒, 原利昭, 遠藤直人
  • Organizer: H22第2回新潟大学VBL成果発表会
  • Place of Presentation: 新潟
  • Year and Date: 2011-03-22
• [Presentation] Effects of Osteoarthritis Progression on the Morphological Structure of Subchondral Plate and Bone : Results from a Rat ACLT Model (2011)
  • Author(s): 松田純平, 目良恒, 原利昭, 遠藤直人
  • Organizer: 57^<th> Annual Meeting of the Orthopaedic Research Society
  • Place of Presentation: ロングビーチ, CA
  • Year and Date: 2011-01-15
• [Presentation] A Novel Method for Evaluating Response of Cells to Biomaterials Loaded Mechanical Strain (2011)
  • Author(s): Junpei MATSUDA, Toshiaki HARA, Naoto ENDO
  • Organizer: 6th World Congress on Biomechanics, in conjuction with 14th International Conference on Biomedical Engineering & 14th Asian Pacific Conference on Biomechanics
• [Presentation] Effects of Osteoarthritis Progression on the Morphological Structure of Subchondral Plate and Bone : Results from a Rat ACLT Model. (2011)
  • Author(s): Junpei MATSUDA, Toshiaki HARA, Naoto ENDO
  • Organizer: 57th Annual Meeting of the Orthopaedic Research Society No.1606
• [Presentation] 軟骨下骨および軟骨下骨プレートに対する変形性関節症の影響 (2011)
  • Author(s): 松田純平, 目良恒, 原利昭, 遠藤直人
  • Organizer: 22年度第2回VBL成果発表会
• [Presentation] A Novel Method for Evaluating Response of Cells to Biomaterials Loaded Mechanical Strain (2010)
  • Author(s): 松田純平, 原利昭, 遠藤直人
  • Organizer: 6th World Congress of Biomechanics
  • Place of Presentation: シンガポール
  • Year and Date: 2010-08-01
• [Presentation] 圧縮荷重下の海綿骨骨梁変形と骨密度分布との関係 (2010)
  • Author(s): 松田純平, 原利昭, 遠藤直人
  • Organizer: 第30回骨形態計測学会
  • Place of Presentation: 米子
  • Year and Date: 2010-05-13
• [Presentation] Response of Osteoblasts on Linearly-increasing Mechanical Strain at a Culture Well (2010)
  • Author(s): 松田純平
  • Organizer: 56^<th> Annual Meeting of the Orthopaedic Research Society
  • Place of Presentation: New Orleans, LA
  • Year and Date: 2010-03-06
• [Presentation] 線形的に増加するひずみ刺激に対する骨芽細胞の応答 (2010)
  • Author(s): 松田純平
  • Organizer: 第22回バイオエンジニアリング講演会
  • Place of Presentation: 岡山
  • Year and Date: 2010-01-09
• [Presentation] Response of Osteoblasts on Linearly-increasing Mechanical Strain at a Culture Well. (2010)
  • Author(s): Junpei MATSUDA, Toshiaki HARA, Naoto ENDO
  • Organizer: 56th Annual Meeting of the Orthopaedic Research Society No.882
• [Presentation] 圧縮荷重下の海綿骨骨梁変形と骨密度分布との関係 (2010)
  • Author(s): 松田純平, 原利昭, 遠藤直人
  • Organizer: 第30回日本骨形態計測学会