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Accuracy improvement for the visualization of nerve fibers by MR diffusion tensor imaging and neurography

Research Project

Project/Area Number 21700463
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biological material science
Research InstitutionKyoto University

Principal Investigator

OIDA Takenori  Kyoto University, 工学研究科, 助教 (70447910)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords生体情報・計測 / 医用・生体画像 / 磁気共鳴画像法 / 拡散強調画像法 / 拡散テンソル画像法 / 線維追跡
Research Abstract

In this study, we performed Monte Carlo simulations of restricted diffusion in a cylinder model and also phantom measurements with capillary plates in order to examine the relationship between the acquisition parameters and the signal intensities in DTI. The results from both the simulations and the phantom measurements suggest that selecting a small q-value is effective in emphasizing fractional anisotropy of the diffusion tensor. Then the simulations were also applied to select the acquisition parameters in DW-fMRI. The simulation results show that selecting large b-value and q-value is effective in measurements of brain activations with DWI. In addition, we developed a new tract ography method by searching minimum curvature deviation to overcome the difficulty of tracking in fiber crossing area.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (25 results)

All 2011 2010 2009

All Journal Article (13 results) (of which Peer Reviewed: 6 results) Presentation (12 results)

  • [Journal Article] Acquisition parameter settings in diffusion tensor imaging for emphasizing fractional anisotropy : phantom study2011

    • Author(s)
      Takenori Oida, Shizue Nagahara, Tetsuo Kobayashi
    • Journal Title

      Magnetic Resonance in Medical Sciences Vol.10, No.2

      Pages: 121-128

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] MR拡散テンソル画像を用いた神経線維追跡における曲率偏差最小化探索法2011

    • Author(s)
      山本詩子, 阪上由英, 笈田武範, 小林哲生
    • Journal Title

      生体医工学 vol.49, No.1

      Pages: 139-147

    • NAID

      130004947415

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acquisition parameter settings in diffusion tensor imaging for emphasizing fractional anisotropy : phantom study2011

    • Author(s)
      Takenori Oida, Shizue Nagahara, Tetsuo Kobayashi
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MR拡散テンソル画像を用いた神経線維追跡における曲率偏差最小化探索法2011

    • Author(s)
      山本詩子, 阪上由英, 笈田武範, 小林哲生
    • Journal Title

      生体医工学

      Volume: (印刷中)

    • NAID

      130004947415

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 拡散強調MR信号強度の撮像パラメータならびに制限サイズ依存性に関する検討2010

    • Author(s)
      永原静恵, 笈田武範, 小林哲生
    • Journal Title

      生体医工学 Vol.48, No.3

      Pages: 281-290

    • NAID

      10031199771

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 拡散強調MR信号強度の撮像パラメータならびに制限サイズ依存性に関する検討2010

    • Author(s)
      永原静恵, 笈田武範, 小林哲生
    • Journal Title

      生体医工学

      Volume: Vol.48 Pages: 281-290

    • NAID

      10031199771

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acquisition parameters in MR diffusion tensor imaging for clarifying the direction of nerve fibers2009

    • Author(s)
      Takenori Oida, Shizue Nagahara, Tetsuo Kobayashi
    • Journal Title

      Brain Topography and Multimodal Imaging

      Pages: 209-212

    • Related Report
      2010 Final Research Report
  • [Journal Article] Appropriate MPG Parameters for Diffusion Weighted Functional MRI2009

    • Author(s)
      Shizue Nagahara, Takenori Oida, Tetsuo Kobayashi
    • Journal Title

      Brain Topography and Multimodal Imaging

      Pages: 213-216

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Journal Article] 神経交叉部における曲率偏差探索を用いたMR-DTI神経線維追跡法2009

    • Author(s)
      笈田武範, 阪上由英, 小林哲生
    • Journal Title

      信学技報 vol.109

      Pages: 147-152

    • Related Report
      2010 Final Research Report
  • [Journal Article] 拡散強調機能的MRIに適した撮像パラメータに関する検討:水分子拡散運動のシミュレーション2009

    • Author(s)
      永原静恵, 笈田武範, 小林哲生
    • Journal Title

      信学技報 vol.109

      Pages: 175-180

    • NAID

      110007338775

    • Related Report
      2010 Final Research Report
  • [Journal Article] Acquisition parameters in MR diffusion tensor imaging for clarifying the direction of nerve fibers2009

    • Author(s)
      Takenori Oida, Shizue Nagahara, Tetsuo kobayashi
    • Journal Title

      Brain Topography and Multimodal Imaging

      Pages: 209-212

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 神経交叉部における曲率偏差探索を用いたMR-DTI神経線維追跡法2009

    • Author(s)
      笈田武範, 阪上由英, 小林哲生
    • Journal Title

      信学技報 109

      Pages: 147-152

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 拡散強調機能的MRIに適した撮像パラメータに関する検討:水分子拡散運動のシミュレーション2009

    • Author(s)
      永原静恵, 笈田武範, 小林哲生
    • Journal Title

      信学技報 109

      Pages: 175-180

    • NAID

      110007338775

    • Related Report
      2009 Annual Research Report
  • [Presentation] 異方性強調のためのDTI撮像パラメータI:シミュレーションおよびファントムによる検討2010

    • Author(s)
      笈田武範, 永原静恵, 小林哲生
    • Organizer
      第38回日本磁気共鳴医学会大会
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Year and Date
      2010-09-30
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 異方性強調のためのDTI撮像パラメータII:in vivo頭部撮像実験による検討2010

    • Author(s)
      永原静恵, 笈田武範, 小林哲生
    • Organizer
      第38回日本磁気共鳴医学会大会
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Year and Date
      2010-09-30
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 拡散強調MRIにおける信号強度のq値依存性:7T-MRIによるキャピラリガラスプレートを用いたファントム実験2010

    • Author(s)
      永原静恵, 笈田武範, 小林哲生
    • Organizer
      生体医工学シンポジウム2010
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2010-09-10
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] MR拡散テンソル画像を用いた神経線維追跡における曲率偏差探索法2010

    • Author(s)
      山本詩子, 阪上由英, 笈田武範, 小林哲生
    • Organizer
      生体医工学シンポジウム2010
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2010-09-10
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Acquisition parameters in MR diffusion tensor imaging for clarifying the direction of nerve fibers2009

    • Author(s)
      Takenori Oida, Shizue Nagahara, Tetsuo Kobayashi
    • Organizer
      18th International Congress on Brain Electromagnetic Topography
    • Place of Presentation
      Kyoto International Community House (Kyoto)
    • Year and Date
      2009-09-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Appropriate MPG parameters for diffusion weighted functional MRI2009

    • Author(s)
      Shizue Nagahara, Takenori Oida, Tetsuo Kobayashi
    • Organizer
      18th International Congress on Brain Electromagnetic Topography
    • Place of Presentation
      Kyoto International Community House (Kyoto)
    • Year and Date
      2009-09-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Acquisition parameters in MR diffusion tensor imaging for clarifying the direction of nerve fibers2009

    • Author(s)
      Takenori Oida, Shizue Nagahara, Tetsuo Kobayashi
    • Organizer
      18th International Congress on Brain Electromagnetic Topography
    • Place of Presentation
      Kyoto International Community House
    • Year and Date
      2009-09-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Appropriate MPG parameters for diffusion weighted functional MRI2009

    • Author(s)
      Shizue Nagahara, Takenori Oida, Tetsuo Kobayashi
    • Organizer
      18th International Congress on Brain Electromagnetic Topography
    • Place of Presentation
      Kyoto International Community House
    • Year and Date
      2009-09-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 神経交叉部における曲率偏差探索を用いたMR-DTI神経線維追跡法2009

    • Author(s)
      笈田武範, 阪上由英, 小林哲生
    • Organizer
      電子情報通信学会医用画像研究会
    • Place of Presentation
      岐阜大学(岐阜県)
    • Year and Date
      2009-05-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 拡散強調機能的MRIに適した撮像パラメータに関する検討:水分子拡散運動のシミュレーション2009

    • Author(s)
      永原静恵, 笈田武範, 小林哲生
    • Organizer
      電子情報通信学会医用画像研究会
    • Place of Presentation
      岐阜大学(岐阜県)
    • Year and Date
      2009-05-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 神経交叉部における曲率偏差探索を用いたMR-DTI神経線維追跡法2009

    • Author(s)
      笈田武範, 阪上由英, 小林哲生
    • Organizer
      電子情報通信学会医用画像研究会
    • Place of Presentation
      岐阜大学
    • Year and Date
      2009-05-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 拡散強調機能的MRIに適した撮像パラメータに関する検討:水分子拡散運動のシミュレーション2009

    • Author(s)
      永原静恵, 笈田武範, 小林哲生
    • Organizer
      電子情報通信学会医用画像研究会
    • Place of Presentation
      岐阜大学
    • Year and Date
      2009-05-29
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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