Development of hydrodynamic levitated centrifugal blood pump for long-term circulatory assist

• Project/Area Number: 21700479
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biomedical engineering/Biological material science
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: KOSAKA Ryou 独立行政法人産業技術総合研究所, ヒューマンライフテクノロジー研究部門, 研究員 (10415680)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 人工臓器工学 / 再生医工学 / 人工心臓 / 動圧軸受 / 流体力学 / 計測工学 / 循環器 / 血液適合性 / ラジアル安定 / 溶血 / 軸受隙間 / 国際情報交換 / イギリス:ドイツ / 流体力 / CFD

Research Abstract

The purpose of this study is to investigate the bearing-gap control for the hydrodynamic-bearing pump to prevent hemolysis. As a result, we confirmed that the hemolysis of was improved by balancing the resultant force acting on the impeller.

Research Products

• [Journal Article] Improvement of hemocompatibility for hydrodynamic levitation centrifugal pump by optimizing step bearings (2011)
  • Author(s): Kosaka R, Yada T, Nishida M, Maruyama O, Yamane T
  • Journal Title: Proc. of the IEEE EMBS Volume: 33 Pages: 1331-1334
  • DOI: 10.1109/iembs.2011.6090313
  • Peer Reviewed
• [Journal Article] Development of Miniaturized Mass-Flow Meter for an Axial Flow Blood Pump based on computational analyses (2011)
  • Author(s): Kosaka R, Nshida M, Maruyama O, Yamane T
  • Journal Title: J Artif Organs Volume: 14 Issue: 3 Pages: 178-184
  • DOI: 10.1007/s10047-011-0569-5
  • Peer Reviewed
• [Journal Article] Noninvasive Miniaturized Mass-flow Meter using a Curved Cannula for Implantable Axial Flow Blood Pump (2011)
  • Author(s): Kosaka R, Nshida M, Maruyama O, Yamane T
  • Journal Title: Proc.Of IEEE EMBC 2011 Volume: 33 Pages: 1343-1346
  • DOI: 10.1109/iembs.2011.6090316
  • Peer Reviewed
• [Journal Article] Development of Miniaturized Mass-Flow Meter for an Axial Flow Blood Pump using a Curved Cannula (2010)
  • Author(s): 小阪亮、西田正浩、丸山修、山根隆志
  • Journal Title: Proc.of 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society Volume: Vol.32 Pages: 2513-2516
  • Peer Reviewed
• [Journal Article] Improvement of Hemocompatibility in a Centrifugal Blood Pump with Hydrodynamic Bearings and a Semi-Open Impeller (2009)
  • Author(s): Kosaka R, Maruyama O, Nishida M, Saito S, Hirai S, Yamane T
  • Journal Title: Artif Organs Volume: 33 Issue: 10 Pages: 798-804
  • DOI: 10.1111/j.1525-1594.2009.00817.x
  • Peer Reviewed
• [Journal Article] 補助循環用動圧浮上式遠心血液ポンプの動圧軸受隙間評価 (2009)
  • Author(s): 吉田文彦、小阪亮、西田正浩、丸山修、矢田亨、川口靖夫、山根隆志
  • Journal Title: 生体医工学シンポジウム Pages: 190-197
  • Peer Reviewed
• [Journal Article] Improvement of Hemocompatibility in a Centrifugal Blood Pump with Hydrodynamic Bearings and a Semi-Open Impeller (2009)
  • Author(s): 小阪亮、矢田亨、丸山修、西田正浩、齋藤栄、平井収作、山根隆志
  • Journal Title: Artif Organs 33 Pages: 798-804
  • Peer Reviewed
• [Presentation] 動圧軸受式遠心血液ポンプのインペララジアル安定性と溶血特性 (2012)
  • Author(s): 安井和哉、小阪亮, 他
  • Organizer: 平成23年度第11回産総研・産技連LS-BT合同研究発表会
  • Place of Presentation: つくば
  • Year and Date: 2012-01-31
• [Presentation] 動圧軸受式遠心血液ポンプのインペララジアル安定性と溶血特性 (2012)
  • Author(s): 安井和哉、小阪亮、西田正浩、丸山修、川口靖夫、山根隆志
  • Organizer: 平成23年度第11回産総研・産技連LS-BT合同研究発表会
  • Place of Presentation: 茨城県、産業技術総合研究所
  • Year and Date: 2012-01-31
• [Presentation] 動圧軸受式遠心ポンプのラジアル運動安定性と溶血特性 (2011)
  • Author(s): 安井和哉、小阪亮, 他
  • Organizer: 第49回日本人工臓器学会大会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-26
• [Presentation] 動圧軸受式遠心ポンプのラジアル運動安定性と溶血特性 (2011)
  • Author(s): 安井和哉、小阪亮、西田正浩、丸山修、川口靖夫、山根隆志
  • Organizer: 第49回日本人工臓器学会大会
  • Place of Presentation: 東京都、都市センターホテル
  • Year and Date: 2011-11-26
• [Presentation] Effect of the Groove on Hydrodynamic Journal Bearing to Impeller Radial Stability and Hemolytic Property of a Centrifugal Blood Pump (2011)
  • Author(s): Yasui K, Kosaka R, et. al
  • Organizer: 19th Congress of the ISRBP
  • Place of Presentation: Louisville, USA
  • Year and Date: 2011-09-09
• [Presentation] Effect of the Groove on Hydrodynamic Journal Bearing to Impeller Radial Stability and Hemolytic Property of a Centrifugal Blood Pump (2011)
  • Author(s): Yasui K, Kosaka R, Nshida M, Maruyama O, Kawaguchi Y, Yamane T
  • Organizer: International Society for Rotary Blood Pumps (ISRBP) 2011
  • Place of Presentation: Louisville, USA Louisville Marriott Downtown Hotel
  • Year and Date: 2011-09-09
• [Presentation] Improvement of hemocompatibility for hydrodynamic levitation centrifugal pump by optimizing step bearings (2011)
  • Author(s): Kosaka R, et. al
  • Organizer: IEEE EMBS 2011
  • Place of Presentation: Boston, USA
  • Year and Date: 2011-08-31
• [Presentation] Noninvasive Miniaturized Mass-flow Meter using a Curved Cannula for Implantable Axial Flow Blood Pump (2011)
  • Author(s): Kosaka R, Nshida M, Maruyama O, Yamane T
  • Organizer: IEEE EMBC 2011
  • Place of Presentation: Boston, USA BOSTON MARRIOTT COPLEY PLACE HOTEL
  • Year and Date: 2011-08-31
• [Presentation] Improvement of Hemocompatibility for Hydrodynamic Levitation Centrifugal Pump by Optimizing Step Bearings (2011)
  • Author(s): Kosaka R, Yada T, Nshida M, Maruyama O, Yamane T
  • Organizer: IEEE EMBC 2011
  • Place of Presentation: Boston, USA BOSTON MARRIOTT COPLEY PLACE HOTEL
  • Year and Date: 2011-08-31
• [Presentation] 遠心血液ポンプの動圧軸受形状がインペララジアル安定性と溶血に及ぼす影響 (2011)
  • Author(s): 安井和哉、小阪亮, 他
  • Organizer: 2011年茨城講演会
  • Place of Presentation: 茨城大
  • Year and Date: 2011-08-26
• [Presentation] 遠心血液ポンプの動圧軸受形状がインペララジアル安定性と溶血に及ぼす影響 (2011)
  • Author(s): 安井和哉、小阪亮、西田正浩、丸山修、川口靖夫、山根隆志
  • Organizer: 機械学会茨城講演会
  • Place of Presentation: 茨城県、茨城大学
  • Year and Date: 2011-08-26
• [Presentation] 軸流型人工心臓のための小型質量流量計の開発と血流評価 (2011)
  • Author(s): 小阪亮、西田正浩、丸山修、山根隆志
  • Organizer: 第39回人工心臓と補助循環懇話会
  • Place of Presentation: 米子(鳥取)
  • Year and Date: 2011-02-18
• [Presentation] 流体力を利用した動圧浮上遠心血液ポンプの軸受隙間の至適化 (2010)
  • Author(s): 小阪亮, 他
  • Organizer: 第48回日本人工臓器学会大会
  • Place of Presentation: 仙台
  • Year and Date: 2010-11-18
• [Presentation] 人工心臓に関わる計測技術 (2010)
  • Author(s): 小阪亮
  • Organizer: 第48回日本人工臓器学会大会
  • Place of Presentation: 仙台(宮城)
  • Year and Date: 2010-11-18
• [Presentation] Development of hydrodynamic levitation centrifugal blood pump and mass-flow meter (2010)
  • Author(s): 小阪亮
  • Organizer: Scientific meeting in Aston University
  • Place of Presentation: Aston University(England)
  • Year and Date: 2010-10-18
• [Presentation] Development of hydrodynamic levitation centrifugal blood pump and mass-flow meter (2010)
  • Author(s): 小阪亮
  • Organizer: 英国アストン大学
  • Place of Presentation: アストン大学(バーミンガム、イギリス)(招待講演)
  • Year and Date: 2010-10-18
• [Presentation] Bearing gap control for a hydrodynamic-bearing centrifugal pump from the viewpoint of hemolysis improvement (2010)
  • Author(s): Kosaka R, et. al
  • Organizer: 18th Congress of the ISRBP
  • Place of Presentation: Berlin
  • Year and Date: 2010-10-15
• [Presentation] Bearing gap control for a hydrodynamic-bearing centrifugal pump from the viewpoint of hemolysis improvement (2010)
  • Author(s): 小阪亮、吉田文彦、丸山修、西田正浩、山根隆志
  • Organizer: International Society for Rotary Blood Pumps 2010
  • Place of Presentation: ベルリン(ドイツ)
  • Year and Date: 2010-10-14
• [Presentation] Evaluation of miniaturized mass-flow meter for an axial flow blood pump with a curved cannula (2010)
  • Author(s): 小阪亮、西田正浩、丸山修、山根隆志
  • Organizer: International Society for Rotary Blood Pumps 2010
  • Place of Presentation: ベルリン(ドイツ)
  • Year and Date: 2010-10-14
• [Presentation] 神への挑戦:人工心臓 (2010)
  • Author(s): 小阪亮
  • Organizer: 富山大学夢大学in工学部2010
  • Place of Presentation: 富山
  • Year and Date: 2010-10-02
• [Presentation] 神への挑戦:人工心臓 (2010)
  • Author(s): 小阪亮
  • Organizer: 夢大学in工学部2010
  • Place of Presentation: 富山大学(富山)(特別招待講演)
  • Year and Date: 2010-10-02
• [Presentation] Development of Miniaturized Mass-Flow Meter for an Axial Flow Blood Pump using a Curved Cannula (2010)
  • Author(s): 小阪亮、西田正浩、丸山修、山根隆志
  • Organizer: 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: ブエノスアイレス(アルゼンチン)
  • Year and Date: 2010-09-02
• [Presentation] 長期耐久性と信頼性を目指した動圧浮上遠心血液ポンプの開発 (2010)
  • Author(s): 小阪亮, 他
  • Organizer: 第22回「電磁力関連のダイナミクス」シンポジウム
  • Place of Presentation: 門司
  • Year and Date: 2010-05-21
• [Presentation] 長期耐久性と信頼性を目指した動圧浮上遠心血液ポンプの開発 (2010)
  • Author(s): 小阪亮、吉田文彦、丸山修、西田正浩、山根隆志
  • Organizer: 第22回「電磁力関連のダイナミクス」シンポジウム
  • Place of Presentation: 門司(福岡)
  • Year and Date: 2010-05-21
• [Presentation] 機械的血液循環補助の技術動向 (2010)
  • Author(s): 山根隆志、小阪亮、西田正浩、丸山修
  • Organizer: 日本機械学会第22回バイオエンジニアリング講演会
  • Place of Presentation: 岡山理科大学(岡山県)
  • Year and Date: 2010-01-09
• [Presentation] 遠心血液ポンプのin vitro抗血栓性試験法 (2009)
  • Author(s): 丸山修、小阪亮、西田正浩、筒井達夫、山根隆志
  • Organizer: 日本定常流ポンプ研究会2009
  • Place of Presentation: 朱鷺メッセ(新潟県)
  • Year and Date: 2009-11-12
• [Presentation] Development of hydrodynamic levitation centrifugal blood pump and mass-flow meter (2009)
  • Author(s): 小阪亮
  • Organizer: Scientific meeting in Chulalongkorn University
  • Place of Presentation: Chulalongkorn University(Thailand)
  • Year and Date: 2009-10-05
• [Presentation] Development of hydrodynamic levitation centrifugal blood pump and mass-flow meter (2009)
  • Author(s): 小阪亮
  • Organizer: Scientific meeting in Chulalongkorn University(招待講演)
  • Place of Presentation: チュラロンコン大学(タイ)
  • Year and Date: 2009-10-05
• [Presentation] Development of hydrodynamic levitation centrifugal blood pump for high durability LVAS (2009)
  • Author(s): Kosaka R, et. al
  • Organizer: 17th Congress of the ISRBP
  • Place of Presentation: Singapore
  • Year and Date: 2009-10-02
• [Presentation] Development of hydrodynamic levitation centrifugal blood pump for high durability LUAS (2009)
  • Author(s): 小阪亮、矢田亨、丸山修、西田正浩、齋藤栄、平井収作、山根隆志
  • Organizer: 17th Congress of the International Society for Rotary Blood Pumps(招待講演)
  • Place of Presentation: Furama Riverfront(シンガポール)
  • Year and Date: 2009-10-02
• [Presentation] 補助循環用動圧浮上式遠心血液ポンプの動圧軸受隙間評価 (2009)
  • Author(s): 吉田文彦、小阪亮, 他
  • Organizer: 生体医工学シンポジウム2009
  • Place of Presentation: 千葉県千葉市
  • Year and Date: 2009-09-25
• [Presentation] 補助循環用動圧浮上式遠心血液ポンプの動圧軸受隙間評価 (2009)
  • Author(s): 吉田文彦、小阪亮、西田正浩、丸山修、矢田亨、川口靖夫、山根隆志
  • Organizer: 生体医工学シンポジウム2009
  • Place of Presentation: 千葉大(千葉県)
  • Year and Date: 2009-09-25
• [Presentation] 補助循環用動圧浮上式遠心血液ポンプの動圧軸受の隙間評価 (2009)
  • Author(s): 吉田文彦、小阪亮, 他
  • Organizer: 日本機械学会茨城講演会2009
  • Place of Presentation: つくば
  • Year and Date: 2009-08-25
• [Presentation] 補助循環用動圧浮上式遠心血液ポンプの動圧軸受の隙間評価 (2009)
  • Author(s): 吉田文彦、小阪亮、西田正浩、丸山修、矢田亨、川口靖夫、山根隆志
  • Organizer: 日本機械学会茨城講演会2009
  • Place of Presentation: 筑波大(茨城県)
  • Year and Date: 2009-08-25
• [Presentation] 回転型血液ポンプの流れの可視化 (2009)
  • Author(s): 山根隆志、西田正浩、丸山修、小阪亮
  • Organizer: 第37回可視化情報シンポジウ
  • Place of Presentation: 工学院大学(東京都)
  • Year and Date: 2009-07-22
• [Remarks] 「大人の社会科見学:人工心臓の開発について」、美的生活Blife 8月号、pp. 26、株式会社ワイズガイ、2009/07/06
• [Patent(Industrial Property Rights)] 遠心血液ポンプ (2012)
  • Inventor(s): 小阪亮、山根隆志、安井和哉
  • Industrial Property Rights Holder: 小阪亮、山根隆志、安井和哉
  • Industrial Property Number: 2012-083186
  • Filing Date: 2012-03-30
• [Patent(Industrial Property Rights)] 遠心血液ポンプ (2012)
  • Inventor(s): 小阪亮
  • Industrial Property Rights Holder: 小阪亮
  • Industrial Property Number: 2012-083211
  • Filing Date: 2012-03-30
• [Patent(Industrial Property Rights)] 遠心血液ポンプ (2012)
  • Inventor(s): 小阪亮、山根隆志、安井和
  • Industrial Property Rights Holder: 産総研
  • Industrial Property Number: 2012-083186
  • Filing Date: 2012-03-30
• [Patent(Industrial Property Rights)] 遠心血液ポンプ (2012)
  • Inventor(s): 小阪亮, 山根隆志
  • Industrial Property Rights Holder: 国立研究開発法人産業技術総合研究所
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-083186
  • Filing Date: 2012-03-30
  • Acquisition Date: 2015-10-30
• [Patent(Industrial Property Rights)] 遠心血液ポンプ (2012)
  • Inventor(s): 小阪 亮
  • Industrial Property Rights Holder: 国立研究開発法人産業技術総合研究所
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-083211
  • Filing Date: 2012-03-30
• [Patent(Industrial Property Rights)] 動圧軸受を備えた人工心臓ポンプ (2011)
  • Inventor(s): 山根隆志、小阪亮、齊藤栄、平井収作
  • Industrial Property Rights Holder: 山根隆志、小阪亮、齊藤栄、平井収作
  • Acquisition Date: 2011-11-18
• [Patent(Industrial Property Rights)] 質量流量計 (2011)
  • Inventor(s): 小阪亮、山根隆志
  • Industrial Property Rights Holder: 産業技術総合研究所
  • Industrial Property Number: 2011-021365
  • Filing Date: 2011-02-03