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Development of 3D-fibrous scaffolds with ability of stimulating mesenchymal stem cells

Research Project

Project/Area Number 21700487
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biological material science
Research InstitutionNagoya Institute of Technology

Principal Investigator

AKIKO Obata  名古屋工業大学, 大学院・工学研究科, 助教 (40402656)

Research Collaborator NAKAMURA Jin  名古屋工業大学, 大学院・工学研究科, 博士後期課程二年
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords生体材料 / 組織工学 / ハイブリッド材料 / 細胞培養 / 立体型不織布 / 骨再建用スキャホールド材料 / エレクトロスピニング / シリコン種イオン
Research Abstract

Novel fibrous materials with three dimensional structure were developed for use in the tissue engineering field. Ceramic particles releasing silicate ions, which have been reported to stimulate cell functions, were combined with biodegradable polymer to prepare fibrous materials enhancing cell proliferation and mineralization. The prepared fibrous materials showed flexibility and elasticity. Results of cell culture tests for the materials showed osteoblast-like cells proliferated inside of the fibrous structure of the materials.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (109 results)

All 2012 2011 2010 2009 Other

All Journal Article (27 results) (of which Peer Reviewed: 25 results) Presentation (72 results) Book (2 results) Remarks (3 results) Patent(Industrial Property Rights) (5 results)

  • [Journal Article] Fabrication of silicate and calcium ion releasable biomaterials with siloxane-containing vaterite2012

    • Author(s)
      Jin Nakamura, Akiko Obata, Toshihiro Kasuga, Julian R Jones
    • Journal Title

      Key Eng. Mater.

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of Fibrous Scaffolds Containing Calcium and Silicon Species2012

    • Author(s)
      Akiko Obata, Hiroki Ozasa, Julian R Jonee, Toshihiro Kasuga
    • Journal Title

      Key Eng.Mater.

      Volume: 493-494 Pages: 840-843

    • DOI

      10.4028/www.scientific.net/kem.493-494.840

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Silicate and Calcium Ions Releasing Biomaterials For Bone Reconstruction2012

    • Author(s)
      Jin Nakamura, Akiko Obata, Julian R.Jones, Toshihiro Kasuga
    • Journal Title

      Key Engineering Materials

      Volume: 493-494 Pages: 561-565

    • DOI

      10.4028/www.scientific.net/kem.493-494.561

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydroxyapatite Coatings Incorporating Silicon Ion Releasing System on Titanium Prepared by Using Water Glass and Vaterite2011

    • Author(s)
      Akiko Obata, Toshihiro Kasuga, Julian R Jones
    • Journal Title

      Journal of the American Ceramic Society

      Volume: 94 Issue: 7 Pages: 2074-2079

    • DOI

      10.1111/j.1551-2916.2011.04402.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Preparation Route on the Degradation Behavior and Ion Releasability of Siloxane-Poly (lactic acid)-Vaterite Hybrid Nonwoven Fabrics for Guided Bone Regeneration2011

    • Author(s)
      Takashi Wakita, Jin Nakamura, Yoshio Ota, Akiko Obata, Toshihiro Kasuga, Seiji Ban
    • Journal Title

      Dental Materials Journal

      Volume: 30 Pages: 232-238

    • NAID

      10028100802

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modification and mechanical properties of electrospun blended fibermat of PLGA and siloxane-containing vaterite/PLLA hybrids for bone repair2011

    • Author(s)
      Gowsihan Poologasundaramapillai, Kie Fujikura, Akiko Obata, Toshihiro Kasuga
    • Journal Title

      eXPRESS Polymer Letters

      Volume: 5 Issue: 10 Pages: 873-881

    • DOI

      10.3144/expresspolymlett.2011.86

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electrospun Microfiber Meshes of Silicon-doped Vaterite/Poly(lactic acid) Hybrid for Guided Bone Regeneration2010

    • Author(s)
      Akiko Obata, Toshiki Hotta, Takashi Wakita
    • Journal Title

      Yoshio Ota and Toshihiro Kasuga Acta Biomaterialia

      Volume: 6 Pages: 1248-1257

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of Silicon-Containing Poly(lactic acid)-Vaterite Hybrid Membranes2010

    • Author(s)
      Akiko Obata, Takashi Wakita, Yoshio Ota and Toshihiro Kasuga
    • Journal Title

      Mater. Sci. Forum

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Electrospun Microfiber Meshes of Silicon-doped Vaterite/Poly(lactic acid) Hybrid for Guided Bone Regeneration2010

    • Author(s)
      Akiko Obata, Toshiki Hotta, Takashi Wakita, Yoshio Ota, Toshihiro Kasuga
    • Journal Title

      Acta Biomaterialia

      Volume: 6 Pages: 1248-1257

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of Electrospun Siloxane-Poly(lactic acid)-Vaterite Hybrid Fibrous Membranes for Guided Bone Regeneration2010

    • Author(s)
      Takashi Wakita, Akiko Obata, Gowsihan Poologasundarampillai, Julian R.Jones, Toshihiro Kasuga
    • Journal Title

      Composites Science and Technology

      Volume: 70 Pages: 1889-1893

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of Siloxane-Containing Vaterite/Poly(lactic acid) Hybrid Fiber mats with Improved Ductility for Bone Regeneration2010

    • Author(s)
      Sen Lin, Kie Fujikura, Akiko Obata, Toshihiro Kasuga
    • Journal Title

      Journal of the Ceramic Society of Japan

      Volume: 118 Pages: 623-625

    • NAID

      130000304602

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of Siloxane-Containing Vaterite/Poly(lactic acid) Hybrid Beads by Electrospraying and HA-coating on Their Surfaces2010

    • Author(s)
      Jin Nakamura, Akiko Obata, Toshihiro Kasuga
    • Journal Title

      Phosphorus Research Bulleten

      Volume: 24 Pages: 1-5

    • NAID

      130004726098

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of Siloxane-Containing Vaterite/Poly(L-lactic acid) Hybrid Microbeads with Silicate and Calcium Ions-Releasing Ability2010

    • Author(s)
      Jin Nakamura, Gowsihan Poologasundarampillai, Akiko Obata, Toshihiro Kasuga
    • Journal Title

      Journal of the Ceramic Society of Japan

      Volume: 118 Pages: 541-544

    • NAID

      130000304785

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of Silicon-Containing Poly(lactic acid)-Vaterite Hybrid Membranes2010

    • Author(s)
      Akiko Obata, Takashi Wakita, Yoshio Ota, Toshihiro Kasuga
    • Journal Title

      Mater.Sci.Forum

      Volume: 638-642 Pages: 670-674

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Structure of CaO-SrO-TiO_2-P_2O_5 Glasses and Their Ion-releasing Abilities in Tris Buffer Solution2010

    • Author(s)
      Sungho Lee, Akiko Obata, Toshihiro Kasuga
    • Journal Title

      Adv.Mater.Res.

      Volume: 89-91 Pages: 342-346

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Electrospun Fibrous Membranes Based on Poly(lactic acid) for Guided Bone Regeneration2009

    • Author(s)
      Akiko Obata, Takashi Wakita, Yoshio Ota and Toshihiro Kasuga
    • Journal Title

      Proc. 22th Inter. Symp. Ceramics in Medicine

      Pages: 579-582

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced in vitro Cell Activity on Silicon-Doped Vaterite/Poly(lactic acid) Composites2009

    • Author(s)
      Akiko Obata, Shingo Tokuda and Toshihiro Kasuga
    • Journal Title

      Acta Biomaterialia

      Volume: 5 Pages: 57-62

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stimulation of Human Mesenchymal Stem Cells and Osteoblasts Activities in vitro on Silicon-Releasable Scaffolds2009

    • Author(s)
      Akiko Obata and Toshihiro Kasuga
    • Journal Title

      Journal of Biomedical Materials Research

      Volume: 91A Pages: 11-17

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced in vitro Cell Activity on Silicon-Doped Vaterite/Poly(lactic acid) Composites2009

    • Author(s)
      Akiko Obata, Shingo Tokuda, Toshihiro Kasuga
    • Journal Title

      Acta Biomater. 5

      Pages: 57-62

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of Poly(lactic acid)/Siloxane/Calcium Carbonate Composite Membranes with Antibacterial Activities2009

    • Author(s)
      Shingo Tokuda, Akiko Obata, Toshihiro Kasuga
    • Journal Title

      Acta Biomater 5

      Pages: 1163-1168

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New Fabrication Process of Layered Membranes Based on Poly(lactic acid) Fibers for Guided Bone Regeneration2009

    • Author(s)
      Takashi Wakita, Akiko Obata, Toshihiro Kasuga
    • Journal Title

      Mater.Trans. 50

      Pages: 1737-1741

    • NAID

      10025154023

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stimulation of Human Mesenchymal Stem Cells and Osteoblasts Activities in vitro on Silicon-Releasable Scaffolds2009

    • Author(s)
      Akiko Obata, Toshihiro Kasuga
    • Journal Title

      J.Biomed.Mater.Res. 91A

      Pages: 11-17

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SiO_2-CaO-P_2O_5 Sol-Gel-Derived Glass Coating on Porous β-tricalcium Phosphate Ceramics2009

    • Author(s)
      Akiko Obata, Toshihiro Kasuga
    • Journal Title

      J.Ceram.Soc.Japan 117

      Pages: 1120-1125

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electrospun Microfiber Meshes of Silicon-doped Vaterite/Poly(lactic acid) Hybrid for Guided Bone Regeneration2009

    • Author(s)
      Akiko Obata, Toshiki Hotta, Takashi Wakita, Yoshio Ota, Toshihiro Kasuga
    • Journal Title

      Acta Biomater. 6

      Pages: 1248-1257

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of electrospun poly(lactic acid)-based hybrids containing siloxane-doped vaterite particles for bone regeneration

    • Author(s)
      Kie Fujikura, Akiko Obata, Sen Lin, Julian R Jones, Robert V Law, Toshihiro Kasuga
    • Journal Title

      Journal of Biomaterials Science : Polymer Edition

      Volume: (In press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hydroxyapatite Coatings Incorporating Silicon Ion Releasing System on Titanium Prepared by Using Water Glass and Vaterite

    • Author(s)
      Akiko Obata, Toshihiro Kasuga, Julian R Jones
    • Journal Title

      Journal of the American Ceramic Society

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Preparation Route on the Degradation Behavior and Ion Releas ability of Siloxane-Poly(lactic acid)-Vaterite Hybrid Nonwoven Fabrics for Guided Bone Regeneration

    • Author(s)
      Takashi Wakita, Jin Nakamura, Yoshio Ota, Akiko Obata, Toshihiro Kasuga, Seiji Ban
    • Journal Title

      Dental Materials Journal

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 溶出ケイ酸イオンによる骨芽細胞への影響2012

    • Author(s)
      小幡亜希子、中村仁、前田浩孝、春日敏宏、Julian R. Jones
    • Organizer
      日本金属学2012年春期大会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] 溶出ケイ酸イオンによる骨芽細胞への影響2012

    • Author(s)
      小幡亜希子、中村仁、前田浩孝、春日敏宏、Julian R Jones
    • Organizer
      日本金属学会2012年春期大会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] ポリ乳酸系綿状構造体中での細胞挙動2012

    • Author(s)
      小笹弘貴、小幡亜希子、前田浩孝、春日敏宏
    • Organizer
      日本セラミックス協会2012年年会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] シロキサン含有バテライト・生分解性ポリマー複合材料不織布の機械的性質及び細胞増殖性2012

    • Author(s)
      藤倉喜恵、小幡亜希子、春日敏宏
    • Organizer
      日本金属学会2012年春期大会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] 無機材質に由来する細胞活性化効果を組込んだ生体材料設計2012

    • Author(s)
      小幡亜希子
    • Organizer
      日本セラミックス協会2012年年会
    • Place of Presentation
      京都(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 硬組織再建用バイオマテリアルの開発2011

    • Author(s)
      小幡亜希子
    • Organizer
      名工大一自然科学研究機構合同講演会第3回講演会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 硬組織再建用バイオマテリアルの開発2011

    • Author(s)
      小幡亜希子
    • Organizer
      名工大-自然科学研究機構合同講演会第3回講演会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effects of silicate and calcium ions on osteoblast functions2011

    • Author(s)
      Akiko Obata, Jin Nakamura, Hirotaka Maeda, Julian R. Jones, Toshihiro Kasuga
    • Organizer
      2^<nd> German-Japanese Seminar on Advanced Ceramic Materials
    • Place of Presentation
      Erlangen, Germany
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Preparation of fibrous scaffolds containing calcium and silicon species2011

    • Author(s)
      Akiko Obata, Hiroki Ozasa, Julian R Jones, Toshihiro Kasuga
    • Organizer
      23^<rd> Symposium and Annual Meeting of International Society for Ceramics in Medicine(ISCM)
    • Place of Presentation
      Istanbul, Turkey
    • Related Report
      2011 Final Research Report
  • [Presentation] 生分解性ポリマー・炭酸カルシウムの複合化による骨再建用材料の創製2011

    • Author(s)
      小幡亜希子、春日敏宏
    • Organizer
      第60回高分子討論会
    • Place of Presentation
      岡山
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 骨芽細胞様細胞に対する溶出シリコンの影響2011

    • Author(s)
      小幡亜希子、春日敏宏
    • Organizer
      日本セラミックス協会第24回秋季シンポジゥム
    • Place of Presentation
      札幌
    • Related Report
      2011 Final Research Report
  • [Presentation] Preparation of fibrous scaffolds containing calcium and silicon species2011

    • Author(s)
      Akiko Obata, Hiroki Ozasa, Julian R Jones, Toshihiro Kasuga
    • Organizer
      Bioceramics23, 23^<rd> Symposium and Annual Meeting of International Society for Ceramics in Medicine (ISCM)
    • Place of Presentation
      Istanbul, Turkey
    • Related Report
      2011 Annual Research Report
  • [Presentation] Imogolite nanotube coating on siloxane-poly (lactic acid)-vaterite composite fibermats2011

    • Author(s)
      Shuji Yamazaki, Sungho Lee, Keiichi Inukai, Katsuya Kato, Akiko Obata, Toshihiro Kasuga
    • Organizer
      The 9^<th> International Meeting of Pacific Rim Ceramic Societies
    • Place of Presentation
      Cairns, Australia
    • Related Report
      2011 Annual Research Report
  • [Presentation] Silicate and Calcium Ions Releasing Biomaterials for Bone Reconstruction2011

    • Author(s)
      Jin Nakamura, Akiko Obata, Toshihiro Kasuga, Julian R Jones
    • Organizer
      Bioceramics23, 23^<rd> Symposium and Annual Meeting of International Society for Ceramics in Medicine (ISCM)
    • Place of Presentation
      Istanbul, Turkey
    • Related Report
      2011 Annual Research Report
  • [Presentation] Preparation of electrospun fibermats from siloxane-containing vaterite/biodegradable polymer composites2011

    • Author(s)
      Kie Fujikura, Sen Lin, Akiko Obata, Toshihiro Kasuga
    • Organizer
      The 28^<th> International Japan-Korea Seminar on Ceramics
    • Place of Presentation
      Okayama, Japan
    • Related Report
      2011 Annual Research Report
  • [Presentation] 骨芽細胞様細胞に対する溶出シリコンの影響2011

    • Author(s)
      小幡亜希子、春日敏宏
    • Organizer
      日本セラミックス協会第24回秋季シンポジウム
    • Place of Presentation
      札幌
    • Related Report
      2011 Annual Research Report
  • [Presentation] シロキサン含有バテライト/ポリ乳酸複合体ファイバーマットの引張強度評価2011

    • Author(s)
      藤倉喜恵、小幡亜希子、Julian R Jones、春日敏宏
    • Organizer
      日本セラミックス協会第24回秋季シンポジウム
    • Place of Presentation
      札幌
    • Related Report
      2011 Annual Research Report
  • [Presentation] シロキサン含有バテライト/ポリ乳酸系綿状材料の作製2011

    • Author(s)
      小笹弘貴、小幡亜希子、春日敏宏
    • Organizer
      日本セラミックス協会第24回秋季シンポジウム
    • Place of Presentation
      札幌
    • Related Report
      2011 Annual Research Report
  • [Presentation] シロキサン含有バテライト粒子の溶解挙動2011

    • Author(s)
      中村仁、小幡亜希子、春日敏宏
    • Organizer
      日本セラミックス協会2011年年会
    • Place of Presentation
      浜松
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨再生誘導膜への応用を目的としたシロキサン・ポリ乳酸・バテライト複合膜のイオン溶出能および分解性2010

    • Author(s)
      脇田剛誌、太田義夫、小幡亜希子、春日敏宏
    • Organizer
      平成22年度日本セラミックス協会東海支部学術研究発表会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-12-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] カルシウム・シリコン含有ポリグルタミン酸系複合体の作製2010

    • Author(s)
      小幡亜希子、春日敏宏、Julian R Jones
    • Organizer
      第14回生体関連セラミックス討論会
    • Place of Presentation
      京都
    • Year and Date
      2010-12-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] シロキサン含有バテライト/ポリ乳酸複合体マイクロビーズのイオン徐放挙動2010

    • Author(s)
      中村仁、小幡亜希子、春日敏宏
    • Organizer
      第14回生体関連セラミックス討論会
    • Place of Presentation
      京都
    • Year and Date
      2010-12-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Biodegradable Materials Releasing Silicon and Calcium Species for Bone Reconstruction2010

    • Author(s)
      小幡亜希子
    • Organizer
      若手研究イノベータ養成センター「ライフサイエンス分野シンポジウム」
    • Place of Presentation
      名古屋
    • Year and Date
      2010-10-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Preparation of Poly γ-glutamic Acid/Vaterite Composites2010

    • Author(s)
      Akiko Obata
    • Organizer
      Imperial College London & Nagoya Institute of Technology Joint Seminar
    • Place of Presentation
      London, U.K.
    • Year and Date
      2010-08-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] カルシウム・シリコン徐放機能を付与した生分解性無機・有機複合体の作製2010

    • Author(s)
      小幡亜希子、春日敏宏、Julian R Jones
    • Organizer
      第32回日本バイオマテリアル学会大会
    • Place of Presentation
      広島(グランドプリンスホテル広島)
    • Related Report
      2011 Final Research Report
  • [Presentation] Calcium Carbonate/Polymer Composites Releasing Silicon and Calcium Species for Biomaterials2010

    • Author(s)
      Akiko Obata, Shinya Yamada, Julian R. Jones, Toshihiro Kasuga
    • Organizer
      The 27^<th> International Korea-Japan Seminar on Ceramics
    • Place of Presentation
      Incheon, Korea
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Preparation of Scaffold Materials Releasing Silicon and Calcium Ions for Bone Reconstruction2010

    • Author(s)
      Akiko Obata, Shinya Yamada, Toshihiro Kasuga, Julian R. Jones
    • Organizer
      3^<rd> International Congress on Ceramics(ICC3)
    • Place of Presentation
      Osaka, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Preparation of Poly(lactic acid)-based Fibrous Membranes Releasing Silicon Species by Electrospinning2010

    • Author(s)
      Akiko Obata, Toshihiro Kasuga, Julian R. Jones
    • Organizer
      ESB 2010(23^<rd> European Conference on Biomaterials)
    • Place of Presentation
      Tampere, Finland
    • Related Report
      2011 Final Research Report
  • [Presentation] Poly(lactic acid)-based Fibrous Membranes Releasing Silicon Species2010

    • Author(s)
      Akiko Obata, Toshihiro Kasuga, Julian R. Jones
    • Organizer
      TERMIS-EU 2010, Galway, Ireland
    • Place of Presentation
      Galway, Ireland
    • Related Report
      2011 Final Research Report
  • [Presentation] Poly(lactic acid)-based Fibrous Membranes Releasing Silicon Species2010

    • Author(s)
      Akiko Obata, Toshihiro Kasuga, Julian R Jones
    • Organizer
      TERMIS-EU 2010
    • Place of Presentation
      Galway, Ireland
    • Related Report
      2010 Annual Research Report
  • [Presentation] Preparation of Poly(lactic acid)-based Fibrous Membranes Releasing Silicon Species by Electrospinning2010

    • Author(s)
      Akiko Obata, Toshihiro Kasuga, Julian R Jones
    • Organizer
      ESB 2010 (23^<rd> European Conference on Biomaterials)
    • Place of Presentation
      Tampere, Finland
    • Related Report
      2010 Annual Research Report
  • [Presentation] Preparation of Scaffold Materials Releasing Silicon and Calcium Ions for Bone Reconstruction2010

    • Author(s)
      Akiko Obata, Shinya Yamada, Toshihiro Kasuga, Julian R Jones
    • Organizer
      3^<rd> International Congress on Ceramics (ICC3)
    • Place of Presentation
      Osaka, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Preparation of Poly γ-glutamic Acid/Calcium Carbonate Composites for Bone Tissue Engineering2010

    • Author(s)
      Akiko Obata, Julian R.Jones, Toshihiro Kasuga
    • Organizer
      4^<th> International Workshop on Advanced Ceramics
    • Place of Presentation
      Nagoya, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Optimization of Fiber Diameter in Electrospun Fibermat for Three Dimensional Tissue Engineering Scaffold2010

    • Author(s)
      K.Fujikura, A.Obata, T.Kasuga
    • Organizer
      ESB 2010 (23^<rd> European Conference on Biomaterials)
    • Place of Presentation
      Tampere, Finland
    • Related Report
      2010 Annual Research Report
  • [Presentation] Preparation of Silicate and Calcium Ion-Releasable Bead-Shaped Siloxane-Containing Vaterite/Poly(L-lactic acid) Hybrids2010

    • Author(s)
      Jin Nakamura, Sen Lin, Gowsihan Poologasundarampillai, Akiko Obata, Toshihiro Kasuga
    • Organizer
      3^<rd> International Congress on Ceramics (ICC3)
    • Place of Presentation
      Osaka, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Preparation of Apatite Coating on Zirconia Ceramics utilizing Vaterite-Particle-Implanted Poly(L-lactic acid) Layer2010

    • Author(s)
      Yuta Kogo, Gowsihan Poologasundarampillai, Akiko Obata, Toshihiro Kasuga
    • Organizer
      3^<rd> International Congress on Ceramics (ICC3)
    • Place of Presentation
      Osaka, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Preparation of Silicate and Calcium Ion-Releasable Bead-Shaped Siloxane-Containing Vaterite/Poly(lactic acid) Hybrids2010

    • Author(s)
      Jin Nakamura, Akiko Obata, Toshihiro Kasuga
    • Organizer
      4^<th> International Workshop on Advanced Ceramics
    • Place of Presentation
      Nagoya, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Apatite Coating on Zirconia Ceramics utilizing Vaterite-Particle-Implanted Poly(L-lactic acid) Layer2010

    • Author(s)
      Yuta Kogo, Gowsihan Poologasundarampillai, Akiko Obata, Toshihiro Kasuga
    • Organizer
      4^<th> International Workshop on Advanced Ceramics
    • Place of Presentation
      Nagoya, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Preparation of Cotton-Like Structured Vaterite/Poly(lactic acid) Composites for Bone Tissue Engineering2010

    • Author(s)
      Hiroki Ozasa, Akiko Obata, Toshihiro Kasuga
    • Organizer
      4^<th> International Workshop on Advanced Ceramics
    • Place of Presentation
      Nagoya, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of Electrospun Scaffolds Having Plate-Like Cross-Linked Areas2010

    • Author(s)
      Shingo Ito, Akiko Obata, Toshihiro Kasuga
    • Organizer
      4^<th> International Workshop on Advanced Ceramics
    • Place of Presentation
      Nagoya, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Preparation of Polymer/SiV Composites for Bone Tissue Engineering2010

    • Author(s)
      Takuma Iwata, Toshiki Hotta, Kie Fujikura, Akiko Obata, Toshihiro Kasuga
    • Organizer
      4^<th> International Workshop on Advanced Ceramics
    • Place of Presentation
      Nagoya, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] カルシウム・シリコン徐放機能を付与した生分解性無機・有機複合体の作製2010

    • Author(s)
      小幡亜希子、春日敏宏、Julian R Jones
    • Organizer
      第32回日本バイオマテリアル学会大会
    • Place of Presentation
      広島
    • Related Report
      2010 Annual Research Report
  • [Presentation] シロキサン含有バテライト/ポリ乳酸ハイブリッド骨修復材料の作製2010

    • Author(s)
      中村仁、小幡亜希子、春日敏宏、伴清治
    • Organizer
      第55回日本歯科理工学会学術講演会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] ケイ酸イオン徐放機能を有した炭酸カルシウム/ポリ乳酸マイクロビーズの作製2010

    • Author(s)
      春日敏宏、中村仁、小幡亜希子
    • Organizer
      日本金属学会2010年秋期(第147回)大会
    • Place of Presentation
      北海道
    • Related Report
      2010 Annual Research Report
  • [Presentation] カルシウム・ケイ酸イオン徐放型骨修復材料の作製2010

    • Author(s)
      中村仁、小幡亜希子、春日敏宏、伴清治
    • Organizer
      第56回日本歯科理工学会学術講演会
    • Place of Presentation
      岐阜
    • Related Report
      2010 Annual Research Report
  • [Presentation] Siloxane-Poly(lactic acid)-Vaterite Hybrid Membranes Prepared by an Electrospinning Method2010

    • Author(s)
      T.Kasuga, A.Obata, T.Wakita, Y.Ota, K.Oribe
    • Organizer
      56th Annual Meeting of the Orthopaedic Research Society
    • Place of Presentation
      New Orleans, Louisiana, U.S.A.
    • Related Report
      2009 Annual Research Report
  • [Presentation] 二層構造を有するポリ乳酸系不織布膜中での細胞挙動2010

    • Author(s)
      山田真也、小幡亜希子、春日敏宏
    • Organizer
      日本セラミックス協会2010年年会
    • Place of Presentation
      小金井
    • Related Report
      2009 Annual Research Report
  • [Presentation] シロキサン/ポリ乳酸/バテライト複合マイクロファイバーマットの生体親和性2010

    • Author(s)
      春日敏宏、小幡亜希子、山田真也、脇田剛誌
    • Organizer
      日本金属学会2010年春期(第146回)大会
    • Place of Presentation
      つくば
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development of New Ceramic-based Materials for Dental Applications2009

    • Author(s)
      Toshihiro Kasuga, Akiko Obata
    • Organizer
      2^<nd> Biomaterials Symposium ~"Hydroxyapatite' Current developments in the synthesis, characterization and applications of apatite-like structures~
    • Place of Presentation
      London, UK
    • Year and Date
      2009-11-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生体活性ハイブリッド材料の金属チタンへのコーティング2009

    • Author(s)
      小野裕二、小幡亜希子、春日敏宏
    • Organizer
      平成21年度日本セラミックス協会東海支部学術研究発表会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-11-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 硬組織代替用セラミックス材料の開発2009

    • Author(s)
      小幡亜希子
    • Organizer
      FAMCO Workshop '09
    • Place of Presentation
      名古屋
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨再生誘導法への応用を目的としたポリ乳酸・炭酸カルシウム複合体不織布の作製2009

    • Author(s)
      小幡亜希子、脇田剛誌、太田義夫、春日敏宏、伴清治
    • Organizer
      平成21年度春期第53回日本歯科理工学会学術講演会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] シリコン種含有ポリ乳酸系ハイブリッド膜の生体適合性評価2009

    • Author(s)
      竹内尚士、町頭三保、山下大輔、宮本元治、武内博信、脇田剛誌、小幡亜希子、春日敏宏、野口和行、伴清治
    • Organizer
      平成21年度春期第53回日本歯科理工学会学術講演会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] 金属チタンへのコーティングを目的としたポリ乳酸系ハイブリッド材料2009

    • Author(s)
      春日敏宏、小野裕二、小幡亜希子
    • Organizer
      日本機械学会2009年度年次大会
    • Place of Presentation
      盛岡
    • Related Report
      2009 Annual Research Report
  • [Presentation] 歯科用コーティング材への応用を目的としたリン酸塩ガラスの作製2009

    • Author(s)
      小幡亜希子、木俣貴文、春日敏宏
    • Organizer
      日本金属学会2009年秋期(第145回)大会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] ジルコニア基板へのPLLAコーティング2009

    • Author(s)
      向後雄太、小幡亜希子、春日敏宏
    • Organizer
      日本金属学会2009年秋期(第145回)大会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] アパタイト分散型ポリ乳酸系多孔質繊維の作製2009

    • Author(s)
      坪井駿一郎、小幡亜希子、春日敏宏
    • Organizer
      日本セラミックス協会第22回秋季シンポジウム
    • Place of Presentation
      愛媛
    • Related Report
      2009 Annual Research Report
  • [Presentation] ポリ乳酸系ファイバーマットへの細胞進入性評価2009

    • Author(s)
      藤倉喜恵、小幡亜希子、春日敏宏
    • Organizer
      日本セラミックス協会第22回秋季シンポジウム
    • Place of Presentation
      愛媛
    • Related Report
      2009 Annual Research Report
  • [Presentation] バテライトを用いた種々の基板のアパタイトコーティング2009

    • Author(s)
      小幡亜希子、長谷川大貴、春日敏宏
    • Organizer
      日本セラミックス協会第22回秋季シンポジウム
    • Place of Presentation
      愛媛
    • Related Report
      2009 Annual Research Report
  • [Presentation] ポリ乳酸/シロキサン含有バテライトハイブリッドマイクロビーズの作製2009

    • Author(s)
      中村仁、小幡亜希子、春日敏宏
    • Organizer
      第19回無機リン化学討論会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] 不織布化技術を用いた二層構造型GBR膜の作製と評価2009

    • Author(s)
      春日敏宏、小幡亜希子、脇田剛誌、太田義夫
    • Organizer
      第31回日本バイオマテリアル学会大会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] Preparation of Poly(lactic acid)-Vaterite Hybrid Membranes for Guided Bone Regeneration2009

    • Author(s)
      Takashi Wakita, Akiko Obata, Yoshio Ota, Toshihiro Kasuga
    • Organizer
      17^<th> Inter.Conf.Composite Materials, British Composite Society
    • Place of Presentation
      Edinburgh, UK
    • Related Report
      2009 Annual Research Report
  • [Presentation] Preparation of Silicon-Containing Poly(lactic acid)-Vaterite Hybrid Membranes2009

    • Author(s)
      Akiko Obata, Takashi Wakita, Yoshio Ota, Toshihiro Kasuga
    • Organizer
      International Conference on Processing and Manufacturing of Advanced Materials 2009 (THERMEC'09)
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2009 Annual Research Report
  • [Presentation] Structure of CaO-SrO-TiO_2-P_2O_5 Glasses and Their Ion-releasing Abilities in Tris Buffer Solution2009

    • Author(s)
      Sungho Lee, Akiko Obata, Toshihiro Kasuga
    • Organizer
      International Conference on Processing and Manufacturing of Advanced Materials 2009 (THERMEC'09)
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2009 Annual Research Report
  • [Presentation] Electrospun Fibrous Membranes Based on Poly(lactic acid) for Guided Bone Regeneration2009

    • Author(s)
      Akiko Obata, Takashi Wakita, Yoshio Ota, Toshihiro Kasuga
    • Organizer
      22th Inter.Symp.Ceramics in Medicine
    • Place of Presentation
      Daegu, Korea
    • Related Report
      2009 Annual Research Report
  • [Presentation] Ion Releasing Abilities of Phosphate Invert Glasses Containing MgO, CaO or SrO in Tris Buffer Solution2009

    • Author(s)
      Sungho Lee, Akiko Obata, Toshihior Kasuga
    • Organizer
      22th Inter.Symp.Ceramics in Medicine
    • Place of Presentation
      Daegu, Korea
    • Related Report
      2009 Annual Research Report
  • [Presentation] Cell-Intercepting Ability of Electrospun Poly(lactic-acid)-based Fibermats2009

    • Author(s)
      Kie Fujikura, Akiko Obata, Toshihiro Kasuga
    • Organizer
      22th Inter.Symp.Ceramics in Medicine
    • Place of Presentation
      Daegu, Korea
    • Related Report
      2009 Annual Research Report
  • [Presentation] Preparation of Poly(lactic acid)/Si-doped Vaterite Hybrid Microbeads2009

    • Author(s)
      Jin Nakamura, Akiko Obata, Toshihiro Kasuga
    • Organizer
      22th Inter.Symp.Ceramics in Medicine
    • Place of Presentation
      Daegu, Korea
    • Related Report
      2009 Annual Research Report
  • [Presentation] Polymer-based Composite Coating on Zirconia Ceramics2009

    • Author(s)
      Yuta Kogo, Akiko Obata, Toshihiro Kasuga
    • Organizer
      22th Inter.Symp.Ceramics in Medicine
    • Place of Presentation
      Daegu, Korea
    • Related Report
      2009 Annual Research Report
  • [Presentation] Preparation of Poly(lactic acid)/Si-doped Vaterite Hybrid Beads by Electrospraying2009

    • Author(s)
      Jin Nakamura, Toshiki Hotta, Akiko Obata, Toshihiro Kasuga
    • Organizer
      9th Asian BioCeramics Symposium (ABC2009)
    • Place of Presentation
      Nagoya
    • Related Report
      2009 Annual Research Report
  • [Presentation] Raman Spectroscopy of SrO-CaO-TiO_2-P_2O_5 Glasses and Their Ion-releasing Abilities in Tris Buffer Solution2009

    • Author(s)
      Sungho Lee, Akiko Obata, Toshihiro Kasuga
    • Organizer
      18th Inter.Symp.Processing and Fabrication of Advanced Materials (PFAM XVIII)
    • Place of Presentation
      仙台
    • Related Report
      2009 Annual Research Report
  • [Presentation] Preparation of Proton Conducting Materials Using Zinc Metaphosphate Glass2009

    • Author(s)
      Toshihiro Kasuga, Takafumi Akamatsu, Masahiro Oka, Akiko Obata
    • Organizer
      18th Inter.Symp.Processing and Fabrication of Advanced Materials (PFAM XVIII)
    • Place of Presentation
      仙台
    • Related Report
      2009 Annual Research Report
  • [Book] Nanoapatite Composite Scaffolds for Bone Regeneration (Chapter 9), Handbook of Nanoceramics and Their Based Nanodevices Vol.52009

    • Author(s)
      Toshihiro Kasuga, Akiko Obata, Hirotaka Maeda
    • Total Pages
      14
    • Publisher
      American Scientific Publishers
    • Related Report
      2009 Annual Research Report
  • [Book] Nova Science Publishers Lactic Acid Production, Properties and Health Effects ; Siloxane-Containing Vaterite/Poly(lactic acid) Fibremats with Improved Ductility

    • Author(s)
      Akiko Obata, Toshihiro Kasuga
    • Publisher
      Nova Science Publishers Lactic Acid(in press)
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://nitzy.mse.nitech.ac.jp/~kasugalab/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://nitzy.mse.nitech.ac.jp/~kasugalab/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://nitzy.mse.nitech.ac.jp/~kasugalab/index.html

    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 骨欠損部充填材料およびその製造方法2010

    • Inventor(s)
      春日敏宏、小笹弘貴、小幡亜希子
    • Industrial Property Rights Holder
      名古屋工業大学
    • Filing Date
      2010-03-31
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 骨欠損部充填材料およびその製造方法2010

    • Inventor(s)
      春日敏宏、小幡亜希子、藤倉喜恵
    • Industrial Property Rights Holder
      名古屋工業大学
    • Industrial Property Number
      2010-080139
    • Filing Date
      2010-03-31
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 骨再生誘導膜およびその製造方法2009

    • Inventor(s)
      春日敏宏、小幡亜希子、藤倉喜恵
    • Industrial Property Rights Holder
      名古屋工業大学
    • Filing Date
      2009-09-10
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 骨欠損部充填材料およびその製造方法2009

    • Inventor(s)
      春日敏宏、小幡亜希子、藤倉喜恵
    • Industrial Property Rights Holder
      名古屋工業大学
    • Industrial Property Number
      2009-163320
    • Filing Date
      2009-07-10
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 骨再生誘導膜およびその製造方法2009

    • Inventor(s)
      春日敏宏、小幡亜希子、藤倉喜恵
    • Industrial Property Rights Holder
      名古屋工業大学
    • Industrial Property Number
      2009-208922
    • Filing Date
      2009-09-10
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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