Reproductive toxicity of nanomaterials for the development of nanomedicine with safety and efficacy

• Project/Area Number: 21700489
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Osaka University
• Principal Investigator: YOSHIOKA Yasuo Osaka University, 臨床医工学融合研究教育センター, 特任講師(常勤) (00392308)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: ナノマテリアル / 非晶質シリカ / 酸化チタン / 薬物送達キャリアー / 体内動態 / 生殖発生 / 胎盤 / 胎仔 / DDS医薬 / 生殖発生毒性

Research Abstract

The increasing use of nanomaterials has raised serious concern about their safety. Here, we investigated the biodistribution of nanomaterials in pregnant mice using nanosilica particles and nano-TiO_2 with different sizes for the clarifying reproductive toxicity. Nanosilica particles of 70 nm diameter and nano-TiO_2 of 35 nm diameter were detected not only in the maternal liver but also in the placenta, although microscale silica particles were not observed in these tissues at all. We believe that these data provide basic information that should help to create nanomaterials that are safe for human exposure.

Research Products

• [Journal Article] NanoSafety Studies of Nanomaterials about Biodistribution and Immunotoxicity (2011)
  • Author(s): Yoshioka Y
  • Journal Title: Yakugaku Zasshi 131(2) Pages: 221-224
  • NAID: 130000451454
• [Journal Article] NanoSafety Studies of Nanomaterials about Biodistribution and Immunotoxicity. (2011)
  • Author(s): Yoshioka Y
  • Journal Title: Yakugaku Zasshi Volume: 131 Pages: 221-4
  • NAID: 130000451454
  • Peer Reviewed
• [Journal Article] Potential adjuvant effect of intranasal urban aerosols in mice through induction of dendritic cell maturation (2010)
  • Author(s): Yoshida T, Yoshioka Y, Fujimura M, Yamashita K, Higashisaka K, Nakanishi R, Morishita Y, Kayamuro H, Nabeshi H, Nagano K, Abe Y, Kamada H, Tsunoda S, Yoshikawa T, Itoh N, Tsutsumi Y
  • Journal Title: Toxicol Lett 199(3) Pages: 383-388
• [Journal Article] Urban aerosols induce pro-inflammatory cytokine production in macrophages and cause airway inflammation in vivo (2010)
  • Author(s): Yoshida T, Yoshioka Y, Fujimura M, Kayamuro H, Yamashita K, Higashisaka K, Nakanishi R, Morishita Y, Nabeshi H, Yamashita T, Muroi M, Tanamoto K, Nagano K, Abe Y, Kamada H, Kawai Y, Mayumi T, Itoh N, Yoshikawa T, Tsunoda S, Tsutsumi Y
  • Journal Title: Biol Pharm Bull 33(5) Pages: 780-783
  • NAID: 130000248036
• [Journal Article] Carbon nanotubes elicit DNA damage and inflammatory response relative to their size and shape (2010)
  • Author(s): Yamashita K, Yoshioka Y, Higashisaka K, Morishita Y, Yoshida T, Fujimura M, Kayamuro H, Nabeshi H, Yamashita T, Nagano K, Abe Y, Kamada H, Kawai Y, Mayumi T, Yoshikawa T, Itoh N, Tsunoda S, Tsutsumi Y
  • Journal Title: Inflammation 33(4) Pages: 276-280
• [Journal Article] Potential adjuvant effect of intranasal urban aerosols in mice through induction of dendritic cell maturation. (2010)
  • Author(s): Yoshida T, Yoshioka Y, et al
  • Journal Title: Toxicol Lett Volume: 199 Pages: 383-8
  • Peer Reviewed
• [Journal Article] Carbon Nanotubes Elicit DNA Damage and Inflammatory Response Relative to Ther Size and Shape. (2010)
  • Author(s): Yamashita K, et al.
  • Journal Title: Inflammation Feb 20.[Epub ahead of print]
  • Peer Reviewed
• [Journal Article] Urban aerosol induce pro-inflammatory cykokine production in macriphages and cause airway inflammation in vivo.
  • Author(s): Yamashida T, et al.
  • Journal Title: Biol Pharm Bull (In press)
  • Peer Reviewed
• [Presentation] Safety assessment of nanomaterials : inflammatory responses of nanosilica with different sizes and surface properties (2010)
  • Author(s): Yoshioka Y, et al
  • Organizer: IUTOX2010
  • Place of Presentation: バルセロナ(スペイン)
  • Year and Date: 2010-07-22
• [Presentation] Silica particle, major component of Asian dust, induces IL-1β production through NALP3 activation mediated by cathepsin B (2010)
  • Author(s): Yoshioka Y, et al
  • Organizer: The ASIA/PACIFIC chapter of the society of environmental toxicology and chemistry 2010 conference
  • Place of Presentation: 広州(中国)
  • Year and Date: 2010-06-06
• [Presentation] ナノ化粧品の安全性確保および安全なナノ化粧品の開発に向けて-2:ナノマテリアルの粒子径と免疫系への影響 (2010)
  • Author(s): 吉岡靖雄、など
  • Organizer: 第35回日本香粧品学会
  • Place of Presentation: 東京
  • Year and Date: 2010-06-03
• [Presentation] Safety assessment of nanomaterials : inflammatory responses of nanosilica with different sizes and surface properties (2010)
  • Author(s): Yoshioka Y, Morishige T, Tsunoda S, Mukai Y, Okada N, Tsutsumi Y, Nakagawa N.
  • Organizer: The XII International Congress of Toxicology
  • Place of Presentation: Barcelona (Spain)
• [Presentation] Silica particle, major component of Asian dust, induces IL-1β production through NALP3 activation mediated by cathepsin B (2010)
  • Author(s): Yoshioka Y, Morishige T, Inakura H, Tsunoda S, Tsutsumi Y, Mukai Y, Okada N, Nakagawa S.
  • Organizer: The Asia/Pasific Chapter of Enviromental Toxicology and Chemistry 2010 Conferece (SETAC)
  • Place of Presentation: Cuangzhou (China)
• [Presentation] ナノ化粧品の安全性確保および安全なナノ化粧品の開発に向けて-2:ナノマテリアルの粒子径と免疫系への影響 (2010)
  • Author(s): 吉岡靖雄,吉川友章,長野一也,阿部康弘,鎌田春彦,今澤孝喜,伊藤徳夫,角田慎一,堤康央
  • Organizer: 第35回日本香粧品学会
  • Place of Presentation: 東京(東京)
• [Presentation] ナノマテリアルの動態特性と免疫毒性 (2010)
  • Author(s): 吉岡靖雄
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山(岡山)
• [Presentation] ナノマテリアルの安全確保に向けて-4 ナノマテリアルの動態特性と免疫毒性 (2009)
  • Author(s): 吉岡靖雄, など
  • Organizer: 第98回日本食品衛生学会学術講演会
  • Place of Presentation: 函館(北海道)
  • Year and Date: 2009-10-09
• [Presentation] ナノマテリアルの安全確保に向けて-4ナノマテリアルの動態特性と免疫毒性 (2009)
  • Author(s): 吉岡靖雄,森重智弘,吉田徳幸,稲倉裕,藤村真穂,鍋師裕美,阿部康弘,長野一也,吉川友章,今澤孝喜,角田慎一,向洋平,岡田直貴,堤康央,中川晋作
  • Organizer: 第98回日本食品衛生学会学術講演会
  • Place of Presentation: 函館(北海道)