Reproductive toxicity of nanomaterials for the development of nanomedicine with safety and efficacy
Project/Area Number |
21700489
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Biomedical engineering/Biological material science
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Research Institution | Osaka University |
Principal Investigator |
YOSHIOKA Yasuo Osaka University, 臨床医工学融合研究教育センター, 特任講師(常勤) (00392308)
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Project Period (FY) |
2009 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | ナノマテリアル / 非晶質シリカ / 酸化チタン / 薬物送達キャリアー / 体内動態 / 生殖発生 / 胎盤 / 胎仔 / DDS医薬 / 生殖発生毒性 |
Research Abstract |
The increasing use of nanomaterials has raised serious concern about their safety. Here, we investigated the biodistribution of nanomaterials in pregnant mice using nanosilica particles and nano-TiO_2 with different sizes for the clarifying reproductive toxicity. Nanosilica particles of 70 nm diameter and nano-TiO_2 of 35 nm diameter were detected not only in the maternal liver but also in the placenta, although microscale silica particles were not observed in these tissues at all. We believe that these data provide basic information that should help to create nanomaterials that are safe for human exposure.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Potential adjuvant effect of intranasal urban aerosols in mice through induction of dendritic cell maturation2010
Author(s)
Yoshida T, Yoshioka Y, Fujimura M, Yamashita K, Higashisaka K, Nakanishi R, Morishita Y, Kayamuro H, Nabeshi H, Nagano K, Abe Y, Kamada H, Tsunoda S, Yoshikawa T, Itoh N, Tsutsumi Y
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Journal Title
Toxicol Lett 199(3)
Pages: 383-388
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[Journal Article] Urban aerosols induce pro-inflammatory cytokine production in macrophages and cause airway inflammation in vivo2010
Author(s)
Yoshida T, Yoshioka Y, Fujimura M, Kayamuro H, Yamashita K, Higashisaka K, Nakanishi R, Morishita Y, Nabeshi H, Yamashita T, Muroi M, Tanamoto K, Nagano K, Abe Y, Kamada H, Kawai Y, Mayumi T, Itoh N, Yoshikawa T, Tsunoda S, Tsutsumi Y
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Journal Title
Biol Pharm Bull 33(5)
Pages: 780-783
NAID
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[Journal Article] Carbon nanotubes elicit DNA damage and inflammatory response relative to their size and shape2010
Author(s)
Yamashita K, Yoshioka Y, Higashisaka K, Morishita Y, Yoshida T, Fujimura M, Kayamuro H, Nabeshi H, Yamashita T, Nagano K, Abe Y, Kamada H, Kawai Y, Mayumi T, Yoshikawa T, Itoh N, Tsunoda S, Tsutsumi Y
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Journal Title
Inflammation 33(4)
Pages: 276-280
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[Presentation] ナノマテリアルの安全確保に向けて-4ナノマテリアルの動態特性と免疫毒性2009
Author(s)
吉岡靖雄,森重智弘,吉田徳幸,稲倉裕,藤村真穂,鍋師裕美,阿部康弘,長野一也,吉川友章,今澤孝喜,角田慎一,向洋平,岡田直貴,堤康央,中川晋作
Organizer
第98回日本食品衛生学会学術講演会
Place of Presentation
函館(北海道)
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