| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Research Abstract |
Purpose of this study is the development of collagen specific intelligent biogelators focused on weak intermolecular interaction during triple-helix formation of collagen fibers. We synthesized multi-armed poly(ethylene glycol)s terminally conjugated with collagen peptides and confirmed supramolecular nanoparticle formation of these compounds. Furthermore, these supramolecular nanoparticles specifically crosslinked fibrous collagens. We also confirmed the effect of the nanoparticles on bullous keratopathy rabbit models. Accordingly, the supramolecular nanoparticles would be useful as a collagen specific biogelator in tissue engineering field.
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