| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
The apatite-cements and -nanocapsule including DNA complex particles were degraded by osteoclast, and the DNA complex was continuously released. When they were injected peri-tumorally into tumor-bearing mice, significant tumor-growth suppression effect was observed, and in some cases, complete disappearance of tumor was achieved. They would be expected as a novel sustained-gene expression device.
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