Development of durable gene expression systems comprising apatitecements or -particles including DNA complex
| Project/Area Number |
21700494
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Musashino University |
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Principal Investigator |
ITO Tomoko Musashino University, 薬学研究所, 特別研究員 (80372910)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ナノバイオ材料 / 遺伝子治療 / 放出制御 / ハイドロキシアパタイト |
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| Research Abstract |
The apatite-cements and -nanocapsule including DNA complex particles were degraded by osteoclast, and the DNA complex was continuously released. When they were injected peri-tumorally into tumor-bearing mice, significant tumor-growth suppression effect was observed, and in some cases, complete disappearance of tumor was achieved. They would be expected as a novel sustained-gene expression device.
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Report
(3 results)
Research Products
(38 results)
