Identification of biomarker for the combination therapy with IFN and ribavirin by the mass spectrometry

• Project/Area Number: 21700507
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Medical systems
• Research Institution: Kobe University
• Principal Investigator: YANO Yoshihiko Kobe University, 大学院・医学研究科, 講師 (60419489)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 検査 / 診断システム / メタボローム解析 / 質量分析計 / 肝炎ウイルス

Research Abstract

Hepatitis virus C is an oncogenic virus to induce liver cirrhosis and hepatocellular carcinoma via chronic inflammation. Pegylated-inferferon (PEG-IFN) and ribavirin (RBV) combination therapy is an established therapy, but its efficacy is still low. Based on this background, identification of unknown biomarkers in relation to therapeutic efficacy was carried out by using of the mass spectrometry. This research would be helpful to develop a future therapy.

Research Products

• [Journal Article] A case of Budd-Chiari syndrome: Gd-EOB-DTPA-enhanced MR findings. (2011)
  • Author(s): Kitajima K, Yoshikawa T, Seo Y, Ohno Y, Yano Y, Miki A, Kanda T, Kanata N, Azuma T, Sugimura K.
  • Journal Title: Magn Reson Imaging. in publication.
• [Journal Article] Activation of Aryl Hydrocarbon Receptor Induces Hepatic Steatosis via Upregulation of Fatty Acid Transport. (2010)
  • Author(s): Kawano Y, Nishiumi S, Tanaka S, Nobutani K, Miki A, Yano Y, Seo, Y, Ashida H, Kutsumi H, Azuma T, Yoshida M.
  • Journal Title: Arch Biochem Biophys. 504 Pages: 221-227
  • NAID: 120003307588
• [Journal Article] Serologic and molecular characteristics of hepatitis B virus among school children in East Java, Indonesia. (2010)
  • Author(s): Utsumi T, Yano Y, Lusida MI, Amin M, Soetjipto, Hotta H, Hayashi Y.
  • Journal Title: Am J Trop Med Hyg 83 Pages: 189-193
• [Journal Article] Activation of Aryl Hydrocarbon Receptor Induces Hepatic Steatosis via Upregulation of Fatty Acid Transport. (2010)
  • Author(s): Kawano Y, et al.
  • Journal Title: Arch Biochem Biophys. Volume: 15;504(2) Pages: 221-7
  • Peer Reviewed
• [Journal Article] Serologic and molecular characteristics of hepatitis B virus among school children in East Java, Indonesia. (2010)
  • Author(s): Utsumi T, et al.
  • Journal Title: Am J Trop Med Hyg. Volume: 83(1) Pages: 189-93
  • Peer Reviewed
• [Journal Article] Clinical significance of hepatitis B virus-DNA in hepatocellular carcinoma negative for hepatitis B virus surface antigen. (2010)
  • Author(s): Tateiwa S, et al.
  • Journal Title: Exper Therapeutic Med. 1 Pages: 343-346
  • Peer Reviewed
• [Journal Article] Molecular epidemiological study of hepatitis viruses in Ismailia, Egypt. (2009)
  • Author(s): Youssef A, Yano Y, Utsumi, El-alah E, El-Hameed A, Serwah A, Hayashi Y.
  • Journal Title: Intervirol 52 Pages: 123-131
• [Journal Article] Complete genome sequence and phylogenetic relatedness of hepatitis B virus isolates in Papua, Indonesia. (2009)
  • Author(s): Utsumi T, Lusida M, Yano Y, Nugrahaputra E, Amin M, Juniastuti, Soetjipto, Hayashi Y. Hotta H.
  • Journal Title: J Clin Microbiol. 47 Pages: 1842-1847
• [Journal Article] Molecular epidemiological study of hepatitis viruses in Ismailia, Egypt. (2009)
  • Author(s): Youssef A, et al.
  • Journal Title: Intervirology. 52(3) Pages: 123-131
  • Peer Reviewed
• [Journal Article] Complete genome sequence and phylogenetic relatedness of hepatitis B virus isolates in Papua, Indonesia. (2009)
  • Author(s): Utsumi T, et al.
  • Journal Title: J Clin Microbiol. 47(6) Pages: 1842-1847
  • Peer Reviewed
• [Journal Article] A case of Budd-Chiari syndrome : Gd-EOB-DTPA-enhanced MR findings.
  • Author(s): Kitajima K, et al.
  • Journal Title: Magn Reson Imaging. Volume: (in press)
  • Peer Reviewed
• [Presentation]
  • Organizer: 第13回日本肝臓学会大会
• [Presentation]
  • Organizer: 第38回日本肝臓学会西部会
• [Presentation]
  • Organizer: 第46回日本肝臓学会総会
• [Presentation]
  • Organizer: 第14回日本肝臓学会大会
• [Remarks] ホームページ等
  • URL: http://www.med.kobe-u.ac.jp/gi/index.htm