The assessment of cancer/testis antigens whether they express the earlystage of cancer and use the targets for the diagnosis for early cancer.

• Project/Area Number: 21700510
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Medical systems
• Research Institution: Kitasato University
• Principal Investigator: FUKUYAMA Takashi 北里大学, メディカルセンター, 上級研究員 (10462251)
• Project Period (FY): 2009 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 検査・診断システム / 癌/精巣抗原 / 癌抗原 / 早期癌診断 / Helicobacter pylori / Mage-A3 / KK-LC-1 / 胃癌 / 抗H. pylori抗体 / 癌 / 発癌初期状態 / 発癌因子 / CagA / MAGE-A3 / 精巣抗原

Research Abstract

Cancer/testis antigens (CTAs) are the proteins expressing various types of cancer but not normal tissues except for germline cells. To assesse whether CTAs is appropriate for the diagnosis of cancer in early stage, I performed the immediate alteration of CTAs in the various cells exposed a carcinogen. I found that cells were started to express CTAs with not only exposure a carcinogen but also acquiring malignancy. Therefore we know that CTAs are fit for the target for diagnosis of early cancer because of the immediately expression with exposure of a carcinogen in conjunction with acquiring malignancy

Research Products

• [Journal Article] Helicobacter pylori, a carcinogen, induces the expression of melanoma antigen -coding gene(Mage) - A 3 , a cancer/testis antigen (2012)
  • Author(s): Fukuyama T. ,Yamazaki T . , Fujita T., Uematsu T., Ichiki Y., Kaneko H., Suzuki T . , Kobayashi N
  • Journal Title: Tumor Biology Volume: 33 Issue: 6 Pages: 1881-1887
  • DOI: 10.1007/s13277-012-0448-6
  • Peer Reviewed
• [Journal Article] Helicobacter pylori, acarcinogen, induces the expression of melanoma antigen-coding gene (Mage)-A3, a cancer/testis antigen (2012)
  • Author(s): Fukuyama Takashi
  • Journal Title: Tumor Biology Volume: 33 Pages: 1881-1887
  • Peer Reviewed
• [Presentation] The induction of specific Cancer/Testis antigens expression by one carcinogen (2012)
  • Author(s): Takashi Fukuyama, Nobue Futawatari, Hitoshi Yamazaki, Taiga Yamazaki, Tomoko Fujita, Takayuki Uematsu, Mariko Ogi, Yoshihito Takahashi, Yatsushi Nishi, Yohei Yasogawa, Yoshinobu Ichiki1, Noritada Kobayashi
  • Organizer: 71st Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Sapporo
  • Year and Date: 2012-09-21
• [Presentation] Helicobacterpyloriによる特定の癌/精巣抗原の発現誘導の可能性 (2012)
  • Author(s): 福山隆 、二渡信江、山崎大賀、藤田智子、植松崇之、高橋禎人、西八嗣、山崎等、市来嘉伸、小林憲忠
  • Organizer: 第16回日本がん免疫学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-07-26
• [Presentation] 一発癌物質Helicobacter pyloriによる特定の癌/精巣抗原の発現誘導の可能性 (2012)
  • Author(s): 福山 隆
  • Organizer: 第16回がん免疫学会総会
  • Place of Presentation: 北海道大学学術交流会館（札幌市）
• [Presentation] The induction of specific Cancer/Testis antigens expression by one carcinogen. (2012)
  • Author(s): Fukuyama Takashi
  • Organizer: The 71st Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: ロイトン札幌（札幌市）
• [Presentation] Malignantly Transformation makes C3H/10T1/2 cells express Cancer/Testis antigen MAGE - A 3 (2011)
  • Author(s): Fukuyama T., Yamazaki T., Fujita T., Uematsu T., Ichiki Y., Kaneko H., Suzuki T., Kobayashi N
  • Organizer: 70th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Sapporo
  • Year and Date: 2011-10-03
• [Presentation] Malignantly Transformation makes C3H/10T1/2 cells express Cancer/Testis antigen MAGE-A3 (2011)
  • Author(s): Fukuyama T., Kobayashi N., et al.
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(名古屋市)
  • Year and Date: 2011-10-03
• [Presentation] Helicobacter pylori is one carcinogenic factor and makes the MAGE-A3,one Cancer/Testis-antigenexpressed (2011)
  • Author(s): Fukuyama T. , Yamazaki T . , Fujita T . , Uematsu T. , IchikiY . , Kaneko H . , Suzuki T ., Kobayashi N
  • Organizer: The INTERNATIONAL UNION OF MICROBIOLOGICAL SOCIETIES 2011 Congress
  • Place of Presentation: Sapporo
  • Year and Date: 2011-09-10
• [Presentation] Helicobacter pylori is one carcinogenic factor and makes the MAGE-A3, one Cancer/Testis-antigen expressed (2011)
  • Author(s): Fukuyama T., Kobayashi N., et al.
  • Organizer: The INTERNATIONAL UNION OF MICROBIOLOGICAL SOCIETIES 2011 Congress
  • Place of Presentation: 札幌コンベンションセンター(札幌市)
  • Year and Date: 2011-09-10
• [Presentation] 癌/精巣抗原は早期癌診断の標的物質になり得るか? - 腫瘍細胞を用いた基礎的解析 - (2011)
  • Author(s): 福山隆、山崎大賀、藤田智子、植松崇之、市来嘉伸、金子博司、鈴木達夫、小林憲忠
  • Organizer: 第15回日本がん免疫学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2011-06-30
• [Presentation] 癌/精巣抗原は早期癌診断の標的物質になり得るか?-腫瘍細胞を用いた基礎的解析- (2011)
  • Author(s): 福山隆、小林憲忠, 他
  • Organizer: 第15回がん免疫学会総会
  • Place of Presentation: 千里ライフサイエンスセンター(大阪府豊中市)
  • Year and Date: 2011-06-30
• [Presentation] As for Cancer / Testis antigens whether it can use for the early diagnosis? (2009)
  • Author(s): 福山隆,小林憲忠,山崎大賀,清水智子,植松崇之,金子博司,鈴木達夫
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大 阪
  • Year and Date: 2009-12-03
• [Presentation] As for Cancer/Testis antigens whether it can use for the early diagnosis? (2009)
  • Author(s): Fukuyama T., Kobayashi N., et al.
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪市
  • Year and Date: 2009-12-03