| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
The feasibility of preparation method of antibody-carrying microbubbles based on the clinically available ultrasound contrast agent, Sonazoid was examined. By utilizing the Annexin V and avidin-biotin complex formation, the attachment of IgG antibodies onto the surface of Sonazoid bubbles was feasible. Although the further study should be required, the molecular targeted-bubbles based on Sonazoid might be applicable to the clinical settings for ultrasound molecular imaging in the near future.
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