Development of neuromuscular electrical stimulation therapy model after spinal cord injury on a rodent

• Project/Area Number: 21700534
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Yamaguchi University
• Principal Investigator: KANCHIKU Tsukasa 山口大学, 医学部附属病院, 助教 (30464324)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 脊髄損傷 / 機能的電気刺激 / ニューロリハビリテーション / リハビリテーション

Research Abstract

We have developed a less invasive rodent model of neuromuscular electrical stimulation(NMES) capable of being combined with spinal cord regeneration therapy. In this study, we evaluated its ability to promote recovery of interlimb control during locomotion. The results suggested that NMES therapy could provide an effective therapeutic tool for neuromotor treatment following incomplete spinal cord injury.

Research Products

• [Journal Article] ラット脊髄損傷後の機能的神経筋電気刺激治療モデルの確立 (2011)
  • Author(s): 寒竹司
  • Journal Title: Journal of Spine Research Volume: 2巻 Pages: 999-1004
  • Peer Reviewed
• [Journal Article] Transplantation of neurospheres derived from bone marrow strormal cells promotes neurological recovery in rats with spinal cord injury (2011)
  • Author(s): Suzuki H, Taguchi T, Kato Y, Kanchiku T
  • Journal Title: Medical Molecular Morphology Volume: Vol.44 Pages: 131-138
  • Peer Reviewed
• [Journal Article] Transplantation of neurospheres derived from bone marrow stromal cells promotes neurological recovery in rats with spinal cord injury (2011)
  • Author(s): Suzuki H, Taguchi T, Kato Y, Kanchiku T
  • Journal Title: Medical Molecular Morphology Volume: 44 Pages: 131-138
  • NAID: 10030463735
  • Peer Reviewed
• [Journal Article] Neuromuscular stimulation therapy after incomplete spinal cord injury promotes interlimb coordination during locomotion (2009)
  • Author(s): Jung Ranu
  • Journal Title: Journal of Neural Engineering 6
  • Peer Reviewed
• [Presentation] A Rodent Model of Functional Neuromuscular Stimulation after Incomplete Spinal Cord injury (2011)
  • Author(s): 寒竹司
  • Organizer: Society for Neuroscience 41st Annual Meeting 2011
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2011-11-13
• [Presentation] ラット脊髄損傷後の機能的電気刺激治療モデルの確立:モデルの低侵襲化と刺激条件の設定 (2011)
  • Author(s): 寒竹司
  • Organizer: 第48回日本リハビリテーション医学会学術集会
  • Place of Presentation: 幕張メッセ,千葉市
  • Year and Date: 2011-11-02
• [Presentation] ラット脊髄損傷後の機能的電気刺激治療モデルの確立:脊髄不全損傷ラットでの三次元動作解析による検討 (2011)
  • Author(s): 寒竹司
  • Organizer: 第26回日本整形外科学会基礎学術集会
  • Place of Presentation: ベシケア分化ホール,前橋市
  • Year and Date: 2011-10-21
• [Presentation] A rodent model of functional neuromuscular stimulation after incomplete spinal cord injury (2011)
  • Author(s): Kanchiku T
  • Organizer: Society for Neuroscience 41^<st> Annual Meeting 2011
  • Place of Presentation: Washington DC, USA
• [Presentation] ラット脊髄損傷後の機能的電気刺激治療モデルの確立:脊髄不全損傷ラットでの三次元動作解析による検討 (2011)
  • Author(s): 寒竹司
  • Organizer: 第26回日本整形外科学会基礎学術集会
  • Place of Presentation: 前橋市,ベイシア分化ホール
• [Presentation] A Rodent Model of Functional Neuromuscular Stimulation after Incomplete Spinal Cord Injury (2010)
  • Author(s): 寒竹司
  • Organizer: Society for Neuroscience 40th Annual Meeting 2010
  • Place of Presentation: SanDiego convension
  • Year and Date: 2010-11-16
• [Presentation] ラット脊髄損傷後の機能的電気刺激治療モデルの確立:刺激条件の設定と三次元動作解析に (2010)
  • Author(s): 寒竹司
  • Organizer: 第25回日本整形外科学会基礎学術集会
  • Place of Presentation: 京都国際会館,京都市
  • Year and Date: 2010-10-15
• [Presentation] ラット脊髄損傷後の機能的電気刺激治療モデルの確立:モデルの低侵襲化と刺激条件の設定 (2010)
  • Author(s): 寒竹司
  • Organizer: 第29回日本運動器移植・再生医学研究会
  • Place of Presentation: 京都テルサ,京都市
  • Year and Date: 2010-09-25
• [Presentation] A Rodent Model of Functional Neuromuscular Stimulation for Motor Therapy after Spinal Cord (2010)
  • Author(s): 寒竹司
  • Organizer: The 28th Annual National Neurotrauma Symposium 2010
  • Place of Presentation: Paris hotel, LasVegas
  • Year and Date: 2010-06-16
• [Presentation] ラット脊髄損傷後の機能的電気刺激治療モデルの確立 (2010)
  • Author(s): 寒竹司
  • Organizer: 第73回西日本脊椎研究会
  • Place of Presentation: 大正製薬株式会社福岡支店,福岡市
  • Year and Date: 2010-06-04
• [Presentation] ラット脊髄損傷後の機能的電気刺激モデルの確立-刺激条件の設定と三次元動作解析による評価 (2010)
  • Author(s): 寒竹司
  • Organizer: 第47回日本リハビリテーション医学会学術集会
  • Place of Presentation: 鹿児島市民文化ホール,鹿児島市
  • Year and Date: 2010-05-21
• [Presentation] A Rodent Model of Functional Neuromuscular Stimulation for Motor Therapy after Spinal Cord Regeneration Therapy (2009)
  • Author(s): 寒竹司
  • Organizer: Society for Neuroscience 39th Annual Meeting 2009
  • Place of Presentation: マコーミックプレイス,シカゴ,アメリカ合衆国
• [Presentation] 三次元動作解析法を用いたラット脊髄損傷後の客観的下肢運動機能評価法の確立-正常ラットでの検討 (2009)
  • Author(s): 寒竹司
  • Organizer: 第46回日本リハビリテーション医学会学術集会
  • Place of Presentation: 静岡グランシップ,静岡市
• [Presentation] ラット脊髄損傷後の機能的電気刺激治療モデルの確立-脊髄再生治療と併用可能なモデルの開発 (2009)
  • Author(s): 寒竹司
  • Organizer: 第38回日本脊椎脊髄病学会
  • Place of Presentation: 神戸ポートピアホテル,神戸市