The effects of early exercise on brain plasticity after focal cerebral infarction in rats.

• Project/Area Number: 21700539
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Kagoshima University
• Principal Investigator: MATSUDA Fumiyo Kagoshima University, 医学部, 助教 (70437953)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 実験的脳梗塞ラットモデル / 早期運動療法 / 神経栄養因子 / 理学療法学 / MidKine

Research Abstract

The purpose of this study was to investigate the effects of early treadmill training after cerebral infarction in rats. This study might provide a basic evidence of rehabilitation medicine. Fifty-four- 8-week old male Wistar rats weighing 200-300g were used in this study. The filament (4-0 nylon suture with blunted tip) was inserted into the left common carotid artery by an arteriotomy. It was then passed up through the lumen of the internal carotid artery and lodged in the narrow proximal anterior cerebral artery, blocking the MCA at its origin. Reperfusion was established by withdrawal of the filament by 90 min. Next day after surgery, stroke rats were randomly assigned to two groups : treadmill-exercised group or non-exercised controls. After ischemia, the rats were received to run on a treadmill for 20 min once a day. All rats were observed the absence of motor coordination and neurological deficits after surgery. The improvement of the motor behavioral and the neurological score in the exercised groups was better than those in non-exercised groups. Particularly, the score in the exercised groups was significantly improved compared with those in non-exercised groups at 14 days after surgery (P<0.05). The runner had the increased expression of midkine (MK) over the non-runner with or without MCA occlusion for 3 days.

Research Products

• [Journal Article] The effects of early exercise on brain damage and recovery after focal cerebral infarction in rats. (2011)
  • Author(s): Matsuda F, Sakakima H, Yoshida Y.
  • Journal Title: Acta Physiol Volume: 201 Pages: 275-287
  • Peer Reviewed
• [Journal Article] Edaravone : a new therapeutic approach for the treatment of acute stroke. (2010)
  • Author(s): Kikuchi K, Kawahara K, Miyagi N, Uchikado H, Kuramoto T, Morimoto Y, Tancharoen S, Miura N, Takenouchi K, Oyama Y, Shrestha B, Matsuda F, Yoshida Y, Arimura S, Mera K, Tada K, Yoshinaga N, Maenosono R, Ohno Y, Hashiguchi T, Maruyama I, Shigemori M.
  • Journal Title: Med Hypotheses. 75(6)(Epub 2010 Aug 21) Pages: 583-285
  • Peer Reviewed
• [Journal Article] Disruption of the midkine gene (Mdk) delays degeneration and regeneration in injured peripheral nerve. (2009)
  • Author(s): Sakakima H, Yoshida Y, Yamazaki Y, Matsuda F, Ikutomo M, Ijiri K, Muramatsu H, Muramatsu T, Kadomatsu K.
  • Journal Title: J Neurosci Res. 87(13) Pages: 2908-2915
  • Peer Reviewed
• [Journal Article] Edaravone attenuates cerebral ischemic injury by suppressing aquaporin-4. (2009)
  • Author(s): Kikuchi K, Tancharoen S, Matsuda F, Biswas KK, Ito T, Morimoto Y, Oyama Y, Takenouchi K, Miura N, Arimura N, Nawa Y, Meng X, Shrestha B, Arimura S, Iwata M, Mera K, Sameshima H, Ohno Y, Maenosono R, Tajima Y, Uchikado H, Kuramoto T, Nakayama K, Shigemori M, Yoshida Y, Hashiguchi T, Maruyama I, Kawahara K
  • Journal Title: Biochem Biophys Res Commun. 25;390(4)(Epub 2009 Sep 6) Pages: 1121-1125
  • Peer Reviewed
• [Journal Article] The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells. (2009)
  • Author(s): Kikuchi K, Kawahara K, Tancharoen S, Matsuda F, Morimoto Y, Ito T, Biswas KK, Takenouchi K, Miura N, Oyama Y, Nawa Y, Arimura N, Iwata M, Tajima Y, Kuramoto T, Nakayama K, Shigemori M, Yoshida Y, Hashiguchi T, Maruyama I.
  • Journal Title: J Pharmacol Exp Ther. 329(3)(Epub 2009 Mar 17) Pages: 865-874
  • Peer Reviewed
• [Journal Article] ミッドカイン機能解析から臨床応用へ神経系におけるミッドカインの働き (2009)
  • Author(s): 吉田義弘, 榊間春利, 松田史代
  • Journal Title: 神経疾患の治療に寄与できるかどうかの検討医学のあゆみ 230巻4号 Pages: 261-265
  • Peer Reviewed
• [Journal Article] The effects of early exercise on brain damage and recovery after focal cerebral infarction in rats.
  • Author(s): Matsuda F, Sakakima H, Yoshida Y.
  • Journal Title: Acta Physiol (Oxf). (2010 Aug 17)
• [Presentation] ラットにおける脳梗塞前の飼育環境やトレッドミル運動が梗塞巣に及ぼす影響 (2010)
  • Author(s): 榊間春利, 重あいり, 松田史代, 生友聖子, 吉田義弘
  • Organizer: 日本理学療法士学術大会
  • Place of Presentation: 岐阜
  • Year and Date: 2010-05-27
• [Presentation] トレッドミル運動介入が老化促進マウスの脊髄前角細胞に及ぼす影響について (2010)
  • Author(s): 沢田浩暢, 松田史代, 入江愛, 渡嘉敷春乃, 榊間春利, 吉田義弘, 米和徳
  • Organizer: 日本理学療法士学術大会
  • Place of Presentation: 岐阜
  • Year and Date: 2010-05-27
• [Presentation] ラットにおける脳梗塞前の飼育環境やトレッドミル運動が梗塞巣に及ぼす影響 (2010)
  • Author(s): 榊間春利, 重あいり, 松田史代, 生友聖子, 吉田義弘
  • Organizer: 日本理学療法士学術大会
  • Place of Presentation: 岐阜県・岐阜市
  • Year and Date: 2010-05-27
• [Presentation] The effects of early exercise on brain damage and recovery after focal cerebral infarction in rats. (2009)
  • Author(s): Fumiyo Matsuda, Harutoshi Sakakima, MASAKO IKUTMO, Yoshihiro Yoshida
  • Organizer: 日本神経科学学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-16
• [Presentation] トレッドミル運動が加齢マウスの関節軟骨に与える影響 (2009)
  • Author(s): 榊間春利, 松田史代, 生友聖子, 入江愛, 嶋田博文, 吉田義弘, 米和徳, 井尻幸成
  • Organizer: 日本理学療法士学術大会
  • Place of Presentation: 東京
  • Year and Date: 2009-05-30
• [Presentation] 吉田義弘脳梗塞ラットにおける早期運動療法介入が脳梗塞巣周辺へ及ぼす効果 (2009)
  • Author(s): 松田史代, 入江愛, 榊間春利, 生友聖子, 米和徳
  • Organizer: 日本理学療法士学術大会
  • Place of Presentation: 東京
  • Year and Date: 2009-05-29
• [Presentation] 脳梗塞ラットにおける早期運動療法介入が脳梗塞巣周辺へ及ぼす効果 (2009)
  • Author(s): 松田史代
  • Organizer: 日本理学療法士学術大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2009-05-28