The effects of early exercise on brain plasticity after focal cerebral infarction in rats.
| Project/Area Number |
21700539
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Kagoshima University |
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Principal Investigator |
MATSUDA Fumiyo Kagoshima University, 医学部, 助教 (70437953)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 実験的脳梗塞ラットモデル / 早期運動療法 / 神経栄養因子 / 理学療法学 / MidKine |
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| Research Abstract |
The purpose of this study was to investigate the effects of early treadmill training after cerebral infarction in rats. This study might provide a basic evidence of rehabilitation medicine. Fifty-four- 8-week old male Wistar rats weighing 200-300g were used in this study. The filament (4-0 nylon suture with blunted tip) was inserted into the left common carotid artery by an arteriotomy. It was then passed up through the lumen of the internal carotid artery and lodged in the narrow proximal anterior cerebral artery, blocking the MCA at its origin. Reperfusion was established by withdrawal of the filament by 90 min. Next day after surgery, stroke rats were randomly assigned to two groups : treadmill-exercised group or non-exercised controls. After ischemia, the rats were received to run on a treadmill for 20 min once a day. All rats were observed the absence of motor coordination and neurological deficits after surgery. The improvement of the motor behavioral and the neurological score in the exercised groups was better than those in non-exercised groups. Particularly, the score in the exercised groups was significantly improved compared with those in non-exercised groups at 14 days after surgery (P<0.05). The runner had the increased expression of midkine (MK) over the non-runner with or without MCA occlusion for 3 days.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Edaravone : a new therapeutic approach for the treatment of acute stroke.2010
Author(s)
Kikuchi K, Kawahara K, Miyagi N, Uchikado H, Kuramoto T, Morimoto Y, Tancharoen S, Miura N, Takenouchi K, Oyama Y, Shrestha B, Matsuda F, Yoshida Y, Arimura S, Mera K, Tada K, Yoshinaga N, Maenosono R, Ohno Y, Hashiguchi T, Maruyama I, Shigemori M.
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Journal Title
Med Hypotheses. 75(6)(Epub 2010 Aug 21)
Pages: 583-285
Related Report
Peer Reviewed
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[Journal Article] Edaravone attenuates cerebral ischemic injury by suppressing aquaporin-4.2009
Author(s)
Kikuchi K, Tancharoen S, Matsuda F, Biswas KK, Ito T, Morimoto Y, Oyama Y, Takenouchi K, Miura N, Arimura N, Nawa Y, Meng X, Shrestha B, Arimura S, Iwata M, Mera K, Sameshima H, Ohno Y, Maenosono R, Tajima Y, Uchikado H, Kuramoto T, Nakayama K, Shigemori M, Yoshida Y, Hashiguchi T, Maruyama I, Kawahara K
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Journal Title
Biochem Biophys Res Commun. 25;390(4)(Epub 2009 Sep 6)
Pages: 1121-1125
Related Report
Peer Reviewed
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[Journal Article] The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells.2009
Author(s)
Kikuchi K, Kawahara K, Tancharoen S, Matsuda F, Morimoto Y, Ito T, Biswas KK, Takenouchi K, Miura N, Oyama Y, Nawa Y, Arimura N, Iwata M, Tajima Y, Kuramoto T, Nakayama K, Shigemori M, Yoshida Y, Hashiguchi T, Maruyama I.
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Journal Title
J Pharmacol Exp Ther. 329(3)(Epub 2009 Mar 17)
Pages: 865-874
Related Report
Peer Reviewed
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