| Project/Area Number |
21700559
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Himeji Dokkyo University |
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Principal Investigator |
MURAKAMI Shinichiro Himeji Dokkyo University, 医療保健学部, 講師 (30454763)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 糖尿病 / 運動療法 / 血糖値 / 微小循環 / 筋毛細血管 / HbAlc / ミオシン重鎖 / 血管内皮細胞増殖因子 / 糖化ヘモグロビン / コハク酸脱水素酵素 |
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| Research Abstract |
The aerobic exercise training has long been utilized as one of therapy in the type 2 diabetes mellitus. The effects of a therapeutic exercise on the myocyte and the microcirculation of skeletal muscle in diabetic rats were investigated. The aerobic exercise program consisted of 2 weeks running on a treadmill (0°incline, 10m/min, 60min/day, 6day/wk). Treated diabetic rats exhibited a decrease in plasma glucose, glycohemoglobin, and reactive oxygen species (ROS) compared with those of the diabetic rats but did not completely normalize levels. Usually, in the soleus muscles of the non-diabetic rats were composed by higher percentage of type I MyHC isoform and lower percentage of type II MyHC isoform. But there were no type II fibers in the soleus muscles of the diabetic rats. The succinate dehydrogenase (SDH) activity in training diabetic rat was significantly higher than that in diabetic rat. The capillary volume in diabetic muscle was significantly less. In the aerobic exercised diabetic muscles, the capillary volumes were increased toward control levels and completely normalize levels. In summary, the results of the present study provide evidence for the effectiveness of exercise training in reducing some of the muscle circulatory complications associated with diabetes mellitus.
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