| Project/Area Number |
21700562
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Mejiro University (2010)
Kibi International University (2009) |
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Principal Investigator |
INOUE SHIGEKI Mejiro University, 保健医療学部, 助教 (40531447)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 培養細胞 / 電磁波障害 / 神経突起形成率 / 三次元様増殖 / 細胞生存率 / 非温熱下 / 電磁波刺激 / マイクロ波治療器 / 最適値 / 致死量 |
|---|
| Research Abstract |
I investigated damage and differentiation of PC12 cells and fibroblast cells caused by microwave irradiation. The frequency of neurite outgrowth induced by 2.45 GHz (200 W) of microwave irradiation was approximately 10-fold greater than that in non-irradiated control cells. Microwave treatment of PC12m3 cells resulted in an increased level of p38 MAPK activity. On the other hand, microwave irradiation had a toxic effect on PC12 parent cells with normal levels of p38 MAPK activity induced by various stimuli. These findings indicate that p38 MAPK is responsible for the survival of PC12m3 cells and might induce neurite outgrowth via a CREB signaling pathway in PC12m3 cells subjected to microwave irradiation.
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