Acceleration mechanism of re-entrainment of circadian rhythms by physical exercise in mammals
| Project/Area Number |
21700650
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Sports science
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| Research Institution | Hokkaido University |
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Principal Investigator |
YAMANAKA yujiro Hokkaido University, 大学院・医学研究科, 助教 (20528343)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | スポーツ生理学 / 生体リズム / 身体運動 / 時差ボケ / 時計遺伝子 / 生物発光 / マウス / スポーツ科学 / 環境生理 / 生物時計 |
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| Research Abstract |
The aim of present study was to clarify acceleration mechanism of re-entrainment of circadian behavioral and clock gene expression rhythm in peripheral tissues (peripheral clocks) to a large shift of light-dark cycle (e.g. jet-lag travel in humans) by physical exercise in mammals. We could demonstrate that the effect of physical exercise, such as exposure to new cage with a running-wheel, on the re-entrainment of peripheral clock was dependent on the timing of exposure. During the transient days in behavior after shift of light cycle, circadian clock gene expression rhythm in the central clock in the suprachiasmatic nucleus (SCN) showed a regional difference in the waveforms and phases. These finding addresses a new hypothesis that the scheduled physical exercise directly affect on the regional oscillator in the SCN. If so, it leads to increase a coupling strength between the SCN and peripheral clock and to accelerate re-entrainment of peripheral clocks by physical exercise.
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Report
(3 results)
Research Products
(34 results)
