Effect of ageing and exercise training on apha-actinin-3 in rat skeletal muscle
| Project/Area Number |
21700662
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Sports science
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
OGURA Yuji 聖マリアンナ医科大学, 医学部, 助教 (90509952)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 筋線維組成 / 加齢 / 骨格筋 / サルコペニア / 運動生理学 / ラット / αアクチニン / 運動器 / αアクチニン3 / 老齢動物 / 運動トレーニング |
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| Research Abstract |
The aim of this study was to clarify the effect of ageing and exercise training on α-actinin-3 in rat skeletal muscle. Our results suggest that ageing-induced muscle atrophy and fast-to-slow shift of the plantaris muscle accompanied with decrease in α-actinin-3, suggesting salcopenia might be associated with α-actinin-3.However, endurance exercise that we selected did not alter α-actinin-3 expression. Thus, endurance-type exercise may not be effective as intervention to α-actinin-3.
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Report
(4 results)
Research Products
(16 results)
