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The basic analysis of connective tissue fibrosis after muscle strain injury

Research Project

Project/Area Number 21700663
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Sports science
Research InstitutionMeiji Gakuin University

Principal Investigator

OCHI Eisuke  Meiji Gakuin University, 教養教育センター, 専任講師 (90468778)

Co-Investigator(Renkei-kenkyūsha) NAKAZATO Koichi  日本体育大学, 大学院・体育科学研究科, 教授 (00307993)
ISHII Naokata  東京大学, 大学院・総合文化研究科, 教授 (20151326)
Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords筋損傷 / エキセントリック収縮 / 結合組織 / 瘢痕化 / 肉離れ / 動物モデル / コラーゲン / in vivo
Research Abstract

The purpose of this study was to investigate the repetitive effects of contraction-induced injury on muscular mass, function, structure, and protein expressions. We employed our originally developed device with lengthening contractions (LCs) mode used in rat gastrocnemius muscle. The results showed that both medial and lateral gastrocnemius muscle were significantly smaller than those in control. The muscle content of myostatin was significantly higher in LCs than in control. In addition, FOXO1 and FOXO3 showed significantly enhanced expression in LCs than in control. These results suggest that repeated bouts of LCs in our model induced decreases in muscular mass and strength. We also observed the activation of protein degradation signaling pathways and myostatin while inactivation of protein synthesis. We conclude that the LCs-induced atrophy and torque deficit are associated with activation of the protein degradation process not apotosis process.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (44 results)

All 2011 2010 2009 Other

All Journal Article (24 results) (of which Peer Reviewed: 18 results) Presentation (14 results) Remarks (6 results)

  • [Journal Article] タイにおける生徒の体力と日常生活に関する研究(第3報)2011

    • Author(s)
      千葉義信, 越智英輔, 黒川貞生, 森田恭光
    • Journal Title

      カルチュール(明治学院大学教養教育センター紀要)

      Volume: 5 Pages: 121-128

    • NAID

      40018822748

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 運動習慣と体格・体力に関する研究2011

    • Author(s)
      千葉義信, 越智英輔, 黒川貞生, 森田恭光
    • Journal Title

      カルチュール(明治学院大学教養教育センター紀要)

      Volume: 5 Pages: 129-134

    • NAID

      40018822749

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 高校生におけるスポーツクラブ活動が健康状況および免疫能に及ぼす影響2011

    • Author(s)
      森田恭光, 越智英輔, 舟木泰世, 熊谷政広, 前野浩嗣, 鈴川一宏
    • Journal Title

      カルチュール(明治学院大学教養教育センター紀要)

      Volume: 5 Pages: 115-120

    • NAID

      40018822747

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Muscular hypertrophy caused by repeated bouts of eccentric exercise and changes in cytokine production in the rat medial gastrocnemius muscle.2011

    • Author(s)
      Ochi E, Ishii N, Nakazato K.
    • Journal Title

      Journal of Strength and Conditioning Research.

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevation of myostatin and FOXOs in prolonged muscular impairment induced by eccentric contractions in rat medial gastrocnemius muscle.2010

    • Author(s)
      Ochi E, Hirose T, Hiranuma K, Min SK, Ishii N, Nakazato K.
    • Journal Title

      Journal of Applied Physiology. 108

      Pages: 306-313

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 肉離れ損傷発生および進行の分子メカニズムに関する仮説2010

    • Author(s)
      中里浩一, 越智英輔, 平沼憲治
    • Journal Title

      整形・災害外科 53

      Pages: 212-213

    • Related Report
      2010 Final Research Report
  • [Journal Article] 大学女子サッカーにおけるハムストリング肉離れの発生要因について2010

    • Author(s)
      若松健太, 越智英輔, 廣瀬立朗, 閔石基, 中里浩一, 平沼憲治
    • Journal Title

      日本臨床スポーツ医学会誌 18

      Pages: 314-319

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The time course of activation of Akt-mTOR-p70S6K signaling pathway in rat gastrocnemius muscle after repeated bouts of eccentric exercise.2010

    • Author(s)
      Ochi E, Ishii N, Nakazato K.
    • Journal Title

      Journal of Sports Science and Medicine. 9

      Pages: 170-175

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 大学女子バレーボール選手におけるアキレス腱炎の発症要因に関する研究2010

    • Author(s)
      富永梨紗子,越智英輔,根本研,森田淳悟,中里浩一, 平沼憲治
    • Journal Title

      日本臨床スポーツ医学会誌 18

      Pages: 456-461

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 青年期における運動・スポーツ活動とメンタルヘルスとの関係2010

    • Author(s)
      永松俊哉, 越智英輔, 他8名
    • Journal Title

      体力研究

      Volume: 108 Pages: 1-7

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 大学女子サッカーにおけるハムストリング肉離れの発生要因について2010

    • Author(s)
      若松健太, 越智英輔, 廣瀬立朗, 閔石基, 中里浩一, 平沼憲治
    • Journal Title

      日本臨床スポーツ医学会誌

      Volume: 18 Pages: 314-319

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The time course of activation of Akt-mTOR-p70S6K signaling pathway in rat gastrocnemius muscle after repeated bouts of eccentric exercise2010

    • Author(s)
      Ochi E, Ishii N, Nakazato K.
    • Journal Title

      Journal of Sports Science and Medicine

      Volume: 9 Pages: 170-175

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 大学女子バレーボール選手におけるアキレス腱炎の発症要因に関する研究2010

    • Author(s)
      富永梨紗子, 越智英輔, 根本研, 森田淳悟, 中里浩一, 平沼憲治
    • Journal Title

      日本臨床スポーツ医学会誌

      Volume: 18 Pages: 456-461

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevation of myostatin and FOXOs in prolonged muscular impairment induced by eccentric contractions in rat medial gastrocnemius muscle.2010

    • Author(s)
      Ochi E, Hirose T, Hiranuma K, Min SK, Ishii N, Nakazato K
    • Journal Title

      Journal of Applied Physiology 108

      Pages: 306-313

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肉離れ損傷発生および進行の分子メカニズムに関する仮説2010

    • Author(s)
      中里浩一, 越智英輔, 平沼憲治.
    • Journal Title

      整形・災害外科 53

      Pages: 212-213

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Physique and physical fitness tests in Udon-Thai province, Kingdom of Thailand.2010

    • Author(s)
      Chiba Y, Ochi E, Morita Y, Kurokawa S.
    • Journal Title

      明治学院大学教養教育センター紀要カルチュール 4

      Pages: 285-292

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 大学男子バレーボール選手におけるジャンパー膝の発症要因に関する研究2009

    • Author(s)
      甲斐健悟, 越智英輔, 森田淳悟, 平沼憲治
    • Journal Title

      日本臨床スポーツ医学会誌 17

      Pages: 522-530

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The cartilage intermediate layer protein gene is associated with lumbar disk degeneration in collegiate judokas.2009

    • Author(s)
      Min SK, Nakazato K, Okada T, Ochi E, Hiranuma K.
    • Journal Title

      Internati-onal Journal of Sports Medicine. 30

      Pages: 691-694

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dietary apple polyphenols have preventive effects against lengthening contraction-induced muscle injuries.2009

    • Author(s)
      Nakazato K, Ochi E, Waga T.
    • Journal Title

      Molecular Nutrition & Food Research. 54

      Pages: 364-372

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 大学男子バレーボール選手におけるジャンパー膝の発症要因に関する研究.2009

    • Author(s)
      甲斐健悟, 越智英輔, 森田淳悟, 平沼憲治
    • Journal Title

      日本臨床スポーツ医学会誌. 17

      Pages: 522-530

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The cartilage intermediate layer protein gene is associated with lumbar disk degeneration in collegiate judokas.2009

    • Author(s)
      Min SK, Nakazato K, Okada T, Ochi E, Hiranuma K.
    • Journal Title

      International Journal of Sports Medicine 30

      Pages: 691-694

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dietary apple polyphenols have preventive effects against lengthening contraction-induced muscle injuries.2009

    • Author(s)
      Nakazato K, Ochi E, Waga T.
    • Journal Title

      Molecular Nutrition & Food Research 54

      Pages: 364-372

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 大学バドミントン競技における腹筋肉ばなれの発生要因

    • Author(s)
      櫻井規子, 中里浩一, 越智英輔, 若松健太, 関根義雄, 平沼憲治
    • Journal Title

      日本臨床スポーツ医学会誌 印刷中

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Muscular hypertrophy caused by repeated bouts of eccentric exercise and changes in cytokine production in the rat medial gastrocnemius muscle.

    • Author(s)
      Ochi E, Nakazato K, Ishii N.
    • Journal Title

      Journal of Strength and Conditioning Research. in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] Differential expressions of protein synthesis and degradation signal pathways after fast/slow velocity eccentric contractions in rat hindlimb.2010

    • Author(s)
      Ochi E, Hirose T, Hiranuma K, Tsutaki A, Seokki M, Ishii N, Nakazato K.
    • Organizer
      2010 Northeast Asia Conference on Kinesiology
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] The effect of myoD, myogenin, and myostatin expression on apoptosis during hindlimb suspension.2010

    • Author(s)
      Hirose T, Ochi E, Tsutaki A, Seokki M, Nakazato K.
    • Organizer
      Physiology 2010
    • Place of Presentation
      Manchester, UK.
    • Related Report
      2010 Final Research Report
  • [Presentation] Effects of lengthening contraction velocity on protein synthesis/degradation signal pathways in rat medial gastrocnemius muscle.2010

    • Author(s)
      Ochi E, Hirose T, Hiranuma K, Tsutaki A, Seokki M, Ishii N, Nakazato K.
    • Organizer
      Physiology 2010
    • Place of Presentation
      Manchester, UK.
    • Related Report
      2010 Final Research Report
  • [Presentation] トレッドミル走の走速度がラット内側腓腹筋におけるPGC-1タンパク質発現に及ぼす影響2010

    • Author(s)
      蔦木新, 越智英輔, 廣瀬立朗, 閔石基, 中里浩一
    • Organizer
      第65回日本体力医学会大会
    • Place of Presentation
      千葉県
    • Related Report
      2010 Final Research Report
  • [Presentation] 伸張性収縮時の角速度の違いが骨格筋内tenomodulin発現に与える影響2010

    • Author(s)
      越智英輔, 廣瀬立朗, 平沼憲治, 石井直方, 中里浩一
    • Organizer
      第65回日本体力医学会大会
    • Place of Presentation
      千葉県
    • Related Report
      2010 Final Research Report
  • [Presentation] 大学ラクロス選手における骨代謝マーカーおよび骨質関連マーカーに関する研究2010

    • Author(s)
      若松健太, 桜庭景植, 丸山麻子, 鹿倉二郎, 越智英輔
    • Organizer
      第21回日本臨床スポーツ医学会学術集会
    • Place of Presentation
      茨城県
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] The effect of myoD, myogenin, and myostatin expression on apoptosis during hindlimb suspension.2010

    • Author(s)
      Hirose T, Ochi E, Tsutaki A, Seokki M, Nakazato K.
    • Organizer
      Physiology 2010
    • Place of Presentation
      Manchester, UK
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effects of lengthening contraction velocity on protein synthesis/degradation signal pathways in rat medial gastrocnemius muscle.2010

    • Author(s)
      Ochi E, Hirose T, Hiranuma K, Tsutaki A, Seokki M, Ishii N, Nakazato K.
    • Organizer
      Physiology 2010
    • Place of Presentation
      Manchester, UK
    • Related Report
      2010 Annual Research Report
  • [Presentation] トレッドミル走の走速度がラット内側腓腹筋におけるPGC-1タンパク質発現に及ぼす影響2010

    • Author(s)
      蔦木新, 越智英輔, 廣瀬立朗, 閔石基, 中里浩一
    • Organizer
      第65回 日本体力医学会大会
    • Place of Presentation
      千葉県
    • Related Report
      2010 Annual Research Report
  • [Presentation] 伸張性収縮時の角速度の違いが骨格筋内tenomodulin発現に与える影響2010

    • Author(s)
      越智英輔, 廣瀬立朗, 平沼憲治, 石井直方, 中里浩一
    • Organizer
      第65回 日本体力医学会大会
    • Place of Presentation
      千葉県
    • Related Report
      2010 Annual Research Report
  • [Presentation] 大学バドミントン競技における腹筋肉ばなれの発生要因2009

    • Author(s)
      櫻井規子, 中里浩一, 越智英輔, 若松健太, 関根義雄, 平沼憲治
    • Organizer
      第64回日本体力医学会大会
    • Place of Presentation
      新潟県
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 尾部懸垂ラット筋委縮におけるデコリンの役割2009

    • Author(s)
      廣瀬立朗, 越智英輔, 閔石基, 中里浩一
    • Organizer
      第64回日本体力医学会大会
    • Place of Presentation
      新潟県
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 14日間の海浜実習中における実技指導者の主観的疲労度と免疫能の研究2009

    • Author(s)
      越智英輔, ほか4名
    • Organizer
      日本運動・スポーツ科学学会第16回大会
    • Place of Presentation
      宮崎県
    • Related Report
      2009 Annual Research Report
  • [Presentation] 青年期の運動・スポーツ活動とメンタルヘルスとの関係2009

    • Author(s)
      越智英輔, ほか8名
    • Organizer
      第64回日本体力医学会大会
    • Place of Presentation
      新潟県
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://mgu-cfla.cc-town.net/modules/staff/staffsingle.php?id=44

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://gyoseki.meijigakuin.ac.jp/mguhp/KgApp?kyoinId=ymdmgdgyggy

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      https://gyoseki.meijigakuin.ac.jp/mguhp/KgApp?kyoinId=ymdmgdgyggy

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://mgu-cfla.cc-town.net/modules/staff/staffsingle.php?id=44

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://mgu-cfla.cc-town.net/modules/staff/staffsingle.php?id=44

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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