Influence of PGC-1αand nuclear receptor gene polymorphisms on endurance performance and muscular mitochondria
| Project/Area Number |
21700666
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Sports science
|
|---|
| Research Institution | Fukuoka University |
|---|
Principal Investigator |
TOBINA Takuro 福岡大学, スポーツ科学部, 助教 (60509678)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 運動 / 骨格筋 / 遺伝子多型 / 核内受容体 / 持久力 / PGC-1α / PPARσ / ミトコンドリア / 転写因子 / PGC-1 / 有酸素性作業能力 |
|---|
| Research Abstract |
Present study investigate whether the gene polymorphisms of PGC-1 and nuclear receptor affects endurance performance and muscular mitochondrial content. The Gly/Gly+Gly/Ser of PGC-1αgene polymorphism, and T/T+T/C of PPARδ gene T294C polymorphism, are significantly higher endurance performance than that of Ser/Ser and C/C, respectively. In exercise training study, the decrease of LDL cholesterol is greater in Gly/Gly than the Gly/Ser, and Ser/Ser. The improvement of lactate threshold intensity is higher in T/T than the T/C, and C/C.
However, those polymorphisms are not affected in muscular mitochondrial content.
|
Report
(4 results)
Research Products
(5 results)
