Large-scale epidemiological study of the effects of gut microbiota on atherosclerosis

• Project/Area Number: 21700686
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Applied health science
• Research Institution: Hirosaki University
• Principal Investigator: DANJO Kazuma 弘前大学, 大学院・医学研究科, 助教 (90463760)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 腸内細菌叢 / 腸内細菌 / 動脈硬化 / PWV (pulse wave velocity) / 岩木健康増進プロジェクト / PWV(pulse wave velocity)

Research Abstract

The aim of this study was to investigate the relationship among gut microbiota, health conditions and certain diseases. The subjects were about 1000 residents of Iwaki area, Hirosaki city. We determined types of gut microbiota, brachial-ankle pulse wave velocity (baPWV) and percentage of body fat, and analysed them. The association between gut microbiota and baPWV was not observed. In female subjects over 65 years old, the ratio of OCU 332 (Lactobacillales) in gut microbiota among the group with BMI less than 20.0 was significantly highest compared with other groups.

Research Products

• [Journal Article] EFFECT OF HUMAN GUT MICROBIOTA ON THE METHANE PRODUCTION (2011)
  • Author(s): Hasebe T, Umeda T, Danjo K, Takahashi I, Matsuzaka M, Kudo J, Semato M, Saito Y, Hisada T, Benno Y, Nakaji S, Hakamada K
  • Journal Title: Hirosaki Medical Journal Volume: 62 Pages: 7-17
  • NAID: 110008425077
• [Journal Article] Prevalence of irritable bowel syndrome and itsrelation to lifestyle and depression quotient in a Japanese general population (2011)
  • Author(s): Kumeta K, Danjo K, MatsuzakaM, Takahashi I, Watanabe K, Iwane K, Tsuya R, Umeda T, Sato K, Fukuda S, Nakaji S
  • Journal Title: Hirosaki Medical Journal Volume: 62 Pages: 144-65
• [Journal Article] 【機能性消化器疾患の基礎と臨床】一般住民におけるIBSの有病率とライフスタイル、心理社会的背景との関連 (2011)
  • Author(s): 佐藤研, 福田眞作, 檀上和真
  • Journal Title: 消化器内科 Volume: 53 Pages: 476-81
• [Journal Article] Effect of human gut microbiota on the methane production (2011)
  • Author(s): Hasebe T, Umeda T. Danjo K, Takahashi I, Matsuzaka M, Kudo J, Semato M, Saito Y, Hisada T, Benno Y, Nakaji S, Hakamada K
  • Journal Title: Hirosaki Medical Journal Volume: 62 Pages: 7-17
  • NAID: 110008425077
  • Peer Reviewed
• [Journal Article] Prevalence of irritable bowel syndrome and its relation to lifestyle and depression quotient in a Japanese general population (2011)
  • Author(s): Kumeta K, Danjo K, Matsuzaka M, Takahashi I, Watanabe K, Iwane K, Tsuya R, Umeda T, Sato K, Fukuda S, Nakaji S
  • Journal Title: Hirosaki Medical Journal Volume: 62 Pages: 144-165
  • NAID: 110008753993
  • Peer Reviewed
• [Presentation] 腸内の乳酸菌と肥満の関連について (2012)
  • Author(s): 渡邉 清誉,高橋一平,本田 勝義,米田 勝朗,三輪 孝士,和田 尚子,伊東 良,上谷英史,梅田 孝,中路 重之
  • Organizer: 第82回日本衛生学
  • Place of Presentation: 京都
• [Presentation] 腸内細菌と体脂肪の関連について (2011)
  • Author(s): 渡邉清誉, 本田勝義, 矢野智彦, 米田勝朗, 三輪孝士, 和田尚子, 伊東良, 小川武志, 梅田孝, 中路重之
  • Organizer: 第21回体力・栄養・免疫学会大会
  • Place of Presentation: 北里大学(東京都)
  • Year and Date: 2011-08-27
• [Presentation] 腸内細菌叢と肥満との関係 (2011)
  • Author(s): 渡邉清誉、梅田孝、黒岩純、竹石洋介、田中充洋、松田基子、中路重之
  • Organizer: 第81回日本衛生学会学術総会
  • Place of Presentation: (誌上開催)
  • Year and Date: 2011-03-27
• [Presentation] 腸内細菌と体脂肪の関連について (2011)
  • Author(s): 渡邉清誉, 本田勝義, 矢野智彦, 米田勝朗,三輪孝士, 和田尚子, 伊東良, 小川武志, 梅田孝, 中路重之
  • Organizer: 第21回体力・栄養・免疫学会大会
  • Place of Presentation: 東京
• [Presentation] 腸内細菌叢と肥満との関係 (2011)
  • Author(s): 渡邉 清誉, 梅田孝, 黒岩純, 竹石洋介, 田中充洋, 松田基子, 中路重之
  • Organizer: 第81回日本衛生学会学術総会
  • Place of Presentation: 誌上開催
• [Presentation] 呼気中水素およびメタン濃度と腸内細菌叢の関連に関する研究 (2010)
  • Author(s): 長谷部達也, 梅田孝, 佐藤弘道, 鈴木隆, 谷本歩実, 徳田糸代, 徳安秀正, 山本博, 矢野智彦, 中路重之
  • Organizer: 第80回日本衛生学会
  • Place of Presentation: 仙台
• [Remarks]
  • URL: http://social.med.hirosaki-u.ac.jp