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Discovery of the function of lipophilic ligand on metabolic disease

Research Project

Project/Area Number 21700692
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Applied health science
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

ADACHI Tetsuya  Kyoto Prefectural University of Medicine, 医学研究科, 助教 (60345014)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsGPCR / GPR30 / ERK / 心臓 / G-タンパク共役型受容体 / 線維芽細胞 / シグナル伝達 / 脂溶性リガンド / 心筋細胞
Research Abstract

The aim of this study is the discovery of the function of lipophilic ligand receptors in metabolic disorder-related organ, such as adipose tissue, skeletal muscle, liver and heart. GPR30, membrane receptor of estrogen, was expressed in adipose tissue, skeletal muscle, liver, primary cardiac myocytes and cardiac myofibroblasts, which are detected in myocardial infarction. Administration of 17β-estradiol induced the phosphorylation of ERK on myocytes and myofibroblasts. These results suggest that estrogen possesses the non-genomic effect via GPR30 in heart.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (3 results)

All 2010 2009

All Journal Article (3 results)

  • [Journal Article] Structure-Activity Relationships of GPR120 Agonists Based on a Docking Simulation.2010

    • Author(s)
      Sun Q, Hirasawa A, Hara T, Kimura I, Adachi T, Awaji T, Ishiguro M, Suzuki T, Miyata N, Tsujimoto G.
    • Journal Title

      Mol Pharmacol. 78

      Pages: 804-810

    • Related Report
      2010 Final Research Report
  • [Journal Article] Association of Estrogen receptor-a gene polymorphisms with cardiac autonomic nervous activity in healthy young Japanese males.2010

    • Author(s)
      Matsunaga T, Gu N, Yamazaki H, Adachi T, Yasuda K, Moritani T, Tsuda K, Nishiyama T, Nonaka M.
    • Journal Title

      Clinica Chimica Acta. 411

      Pages: 505-509

    • Related Report
      2010 Final Research Report
  • [Journal Article] Novel selective ligands for free fatty acid receptors GPR120 and GPR40.2009

    • Author(s)
      Hara T, Hirasawa A, Sun Q, Sadakane K, Itsubo C, Iga T, Adachi T, Koshimizu TA, Hashimoto T, Asakawa Y, Tsujimoto G.
    • Journal Title

      Naunyn Schmiedebergs Arch Pharmacol. 380

      Pages: 247-255

    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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