Molecular epidemiological study regarding the influence of physical activity and obesity on systemic inflammation

• Project/Area Number: 21700695
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Applied health science
• Research Institution: Saga University
• Principal Investigator: NISHIDA Yuichirou 佐賀大学, 医学部, 助教 (50530185)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 運動処方と運動療法 / 全身性炎症 / 身体活動 / 肥満 / 遺伝子 / 生活習慣病

Research Abstract

We investigated associations of accelerometer-determined physical activity with circulating levels of inflammatory cytokines (IL-6, IL-8, IL-15, and TNF-α) in middle-aged Japanese people. Present analysis comprised 2123 eligible participants (893 men and 12130 women) aged 40 to 69 years. The daily step count and physical activity level were inversely associated with IL-6 IL-15, and TNF-α. As a result of analyzing the influence of physical activity intensity, we found that moderate plus vigorous physical activity were inversely related to TNF-α level, and these associations remained statistically significant even after adjustments with BMI and waist circumference. The current results suggest that an increase in the amount of moderate plus vigorous activity in daily life may contribute to a better level of TNF-α concentration.

Research Products

• [Presentation] 身体活動が血中IL―6、IL―8、IL―15、TNF―αに及ぼす影響 (2012)
  • Author(s): 西田裕一郎, 桧垣靖樹, 田口尚人, 原めぐみ, 中村和代, 南里妃名子, 今泉猛, 坂本龍彦, 堀田美加子, 新地浩一, 田中恵太郎
  • Organizer: 第２２回日本疫学会学術総会
  • Place of Presentation: 一ツ橋記念会堂(東京都)
  • Year and Date: 2012-01-27
• [Presentation] 身体活動が血中IL-6,IL-8,IL-15,TNF-αに及ぼす影響 (2012)
  • Author(s): 西田裕一郎
  • Organizer: 日本疫学会
  • Place of Presentation: 一ツ橋記念会堂(東京都)
  • Year and Date: 2012-01-27
• [Presentation] Greater light-intensity physical activity is associated with higher levels of total and high-molecular-weight adiponectin (2010)
  • Author(s): Yuichiro Nishida, Yasuki Higaki, Naoto Taguchi, Megumi Hara, Kazuyo Nakamura, Hinako Nanri, Takeshi Imaizumi, Tatsuhiko Sakamoto, Mikako Horita, Koichi Shinchi, Keitaro Tanaka
  • Organizer: The Joint Scientific Meeting of the International Epidemiological Association Western Pacific Region and the 20^<th> Japan epidemiological Association
  • Place of Presentation: Saitama, Japan
  • Year and Date: 2010-01-09