Role of mitochondrial function in stress systems
| Project/Area Number |
21700698
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied health science
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| Research Institution | Osaka City University |
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Principal Investigator |
KASAHARA Emiko 大阪市立大学, 大学院・医学研究科, 特任講師 (30468269)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ストレス / ミトコンドリア / 自然免疫 / マクロファージ / 糖・脂質代謝 / 脂肪肝 / 脂質 / 糖 / 免疫学 |
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| Research Abstract |
In this study, we investigated the effect of stress condition on the energy metabolisms and immune systems using the mouse received restraint stress. Our results suggest that(1) restraint stress induce mitochondrial dysfunction in the liver resulting hepatic steatosis and dysfunction,(2) stress-induced glucocorticoid release affect mitochondrial function and regulate innate immune systems.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Effect of oxidative stress during repeated ovulation on the structure and functions of the ovary, oocytes, and their mitochondria2010
Author(s)
K. Miyamoto, E. F. Sato, E. Kasahara, M. Jikumaru, K. Hiramoto, H. Tabata, M. Katsuragi, S. Odo, K. Utsumi, M. Inoue
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Journal Title
Free Radic Biol Med
Volume: 49
Issue: 4
Pages: 674-81
DOI
Related Report
Peer Reviewed
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