Role of mitochondrial function in stress systems

• Project/Area Number: 21700698
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Applied health science
• Research Institution: Osaka City University
• Principal Investigator: KASAHARA Emiko 大阪市立大学, 大学院・医学研究科, 特任講師 (30468269)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: ストレス / ミトコンドリア / 自然免疫 / マクロファージ / 糖・脂質代謝 / 脂肪肝 / 脂質 / 糖 / 免疫学

Research Abstract

In this study, we investigated the effect of stress condition on the energy metabolisms and immune systems using the mouse received restraint stress. Our results suggest that(1) restraint stress induce mitochondrial dysfunction in the liver resulting hepatic steatosis and dysfunction,(2) stress-induced glucocorticoid release affect mitochondrial function and regulate innate immune systems.

Research Products

• [Journal Article] Mitochondrial density contributes to immune response of macrophages to lipopolysaccharide via a MAPK pathway (2011)
  • Author(s): E. Kasahara, A. Sekiyama, M. Hori, K. Hara, N. Takahashi, M. Konishi, E. F. Sato, S. Matsumoto, H. Okamura, M. Inoue
  • Journal Title: FEBS Letter Volume: 585 Issue: 14 Pages: 2263-2268
  • DOI: 10.1016/j.febslet.2011.05.049
  • Peer Reviewed
• [Journal Article] Role of the Hypothalamo-Pituitary-Adrenal Axis in the Modulation of Pollinosis Induced by Pollen Antigens (2010)
  • Author(s): M. Hashimoto, E. F. Sato, K. Hiramoto, E. Kasahara, M. Inoue
  • Journal Title: Allergology International Volume: 59 Issue: 2 Pages: 201-206
  • DOI: 10.2332/allergolint.09-OA-0133
  • NAID: 130004477086
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] Effect of oxidative stress during repeated ovulation on the structure and functions of the ovary, oocytes, and their mitochondria (2010)
  • Author(s): K. Miyamoto, E. F. Sato, E. Kasahara, M. Jikumaru, K. Hiramoto, H. Tabata, M. Katsuragi, S. Odo, K. Utsumi, M. Inoue
  • Journal Title: Free Radic Biol Med Volume: 49 Issue: 4 Pages: 674-81
  • DOI: 10.1016/j.freeradbiomed.2010.05.025
  • Peer Reviewed
• [Presentation] マクロファージのLPS応答におけるミトコンドリアの役割 (2011)
  • Author(s): 笠原恵美子
  • Organizer: 日本生化学会
  • Place of Presentation: 国立京都国際会館京都
  • Year and Date: 2011-09-12
• [Presentation] Role of mitochondrial ROS in response of macrophage to LPS (2011)
  • Author(s): E. Kasahara, A. Sekiyama, M. Hori, K. Hiramoto, Y. Yamate, M. Inoue, S. Kitagawa
  • Organizer: 11th Conference of Japanese Society of Mitochondrial Research and Medicine
  • Place of Presentation: Kagoshima
  • Year and Date: 2011-09-02
• [Presentation] Role of mitochondrial ROS in response of macrophage to LPS (2011)
  • Author(s): 笠原恵美子
  • Organizer: 11th Conference of Japanese Society of Mitochondrial Research and Medicine
  • Place of Presentation: 鹿児島市民ホール鹿児島市
  • Year and Date: 2011-09-02
• [Presentation] Restraint stress induces mitochondrial dysfunction in the liver (2011)
  • Author(s): E. Kasahara, A. Sekiyama, M. Hori, D. Kuratsune, E. F. Sato, M. Inoue
  • Organizer: Society of Biological Psychiatry
  • Place of Presentation: San Francisco
  • Year and Date: 2011-05-12
• [Presentation] Restraint stress induces mitochondrial dysfunction in the liver (2011)
  • Author(s): 笠原恵美子
  • Organizer: Society of Biological Psychiatry
  • Place of Presentation: Embarcadero Center San Francisco
  • Year and Date: 2011-05-12
• [Presentation] 拘束ストレス負荷による免疫応答の抑制とミトコンドリアの関与 (2010)
  • Author(s): 笠原恵美子
  • Organizer: 第83回 日本生化学会
  • Place of Presentation: 神戸国際会議場(神戸)
  • Year and Date: 2010-12-07
• [Presentation] 自然免疫応答におけるミトコンドリアの役割 (2010)
  • Author(s): 笠原恵美子
  • Organizer: 第5回 臨床ストレス応答学会
  • Place of Presentation: 徳島大学 メディカルホール
  • Year and Date: 2010-11-19
• [Presentation] Restraint stress-induced glucocorticoid up-regulates UCP2 expression to suppress mitochondrial ROS generation and increase the resistance of the mice to septic shock (2010)
  • Author(s): E. Kasahara, A. Sekiyama, M. Hori, D. Chida, M. Inoue
  • Organizer: 7th World Congress on Stress
  • Place of Presentation: Leiden, Holland
  • Year and Date: 2010-08-25
• [Presentation] Restraint stress-induced glucocorticoid upregulates UCP2 expression b suppress mitochondrial ROS generation and increase the resistance of the mice to septic shock. (2010)
  • Author(s): 笠原恵美子
  • Organizer: 17th World Congress on Stress
  • Place of Presentation: Leiden大学(オランダ)
  • Year and Date: 2010-08-25
• [Presentation] ストレス負荷によるミトコンドリアの活性酸素代謝変動と自然免疫応答の低下 (2010)
  • Author(s): 笠原恵美子
  • Organizer: 第6回 日本疲労学会
  • Place of Presentation: 大阪産業創造館
  • Year and Date: 2010-06-25
• [Presentation] Restraint stress induces mitochondrial dysfunction in the liver (2009)
  • Author(s): 笠原恵美子
  • Organizer: ミトコンドリア学会
  • Place of Presentation: 東京大学医学部鉄門記念講堂(東京)
  • Year and Date: 2009-12-18
• [Presentation] ストレス負荷によるUCP2の発現上昇と自然免疫応答の低下 (2009)
  • Author(s): 笠原恵美子
  • Organizer: 第82回日本生化学会
  • Place of Presentation: 神戸国際会議場(神戸)
  • Year and Date: 2009-10-23
• [Presentation] Restraint stress induces mitochondrial dysfunction and decreases ATP content in the liver (2009)
  • Author(s): 笠原恵美子
  • Organizer: The 4th Annual Meeting of The Biomedical Society for Stress Response
  • Place of Presentation: Gateaux Kingdom Sapporo Hotel(札幌)
  • Year and Date: 2009-10-08