Effects of estrogen receptor-related gene polymorphisms on exercise-induced reduction of arterial stiffness
| Project/Area Number |
21700699
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied health science
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| Research Institution | Sapporo Otani University |
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Principal Investigator |
HAYASHI Koichiro Sapporo Otani University, 人間開発学部, 准教授 (90433474)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 動脈硬化 / 身体活動 / 遺伝子多型 / エストロゲン受容体 / 女性 / 遺伝子型 |
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| Research Abstract |
In the present study, I examined the hypothesis that gene polymorphisms of estrogen receptor (ER) -α and -β might influence the ability of regular exercise to improve arterial stiffness in premenopausal women. The results showed that the one polymorphism in ER-β affects arterial stiffness and that one of polymorphism in ER-αand three of polymorphisms in ER-β affects regular exercise-induced reduction of arterial stiffness. These results suggest that estrogen receptor-related gene polymorphisms are candidate for determining regular exercise-related reduction of arterial stiffness in premenopausal Japanese women.
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Report
(3 results)
Research Products
(22 results)
