Relationships between flexibility, arterial stiffening and the sympathetic nervous system

• Project/Area Number: 21700706
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Applied health science
• Research Institution: National Institute of Health and Nutrition
• Principal Investigator: YAMAMOTO Kenta National Institute of Health and Nutrition, 健康増進プログラム, 客員研究員 (80434380)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: 生活習慣病 / 柔軟性 / 交感神経活動 / 加齢 / 動脈硬化度 / 体力

Research Abstract

The present study tested the following hypothesis : (1) a stretching intervention for 6 months will attenuate arterial stiffening ; and (2) the sympathetic nervous system mediates the relationship between flexibility and arterial stiffness. The results suggest that (1) improving flexibility induced by stretching exercise attenuates arterial stiffening with aging ; and (2) that this relationship between flexibility and arterial stiffening might not be mediated by the sympathetic nervous system. Although the present study failed to clarify the mechanisms for the relationship between flexibility and arterial stiffness, this study indicates a possibility that flexibility exercise should be integrated as a new recommendation into the known cardiovascular benefit of regular exercise.

Research Products

• [Journal Article] PPAR{gamma}2 C1431T genotype increases metabolic syndrome risk in young men with low cardiorespiratory fitness. (2011)
  • Author(s): Sanada K, Iemitsu M, Murakami H, Tabata I, Yamamoto K, Gando Y, Suzuki K, Higuchi M, Miyachi M.
  • Journal Title: Physiol Genomics 43 Pages: 103-109
• [Journal Article] PPAR{gamma}2 C1431T genotype increases metabolic syndrome risk in young men with low cardiorespiratory fitness (2011)
  • Author(s): Sanada K, Iemitsu M, Murakami H, Tabata I, Yamamoto K, Gando Y, Suzuki K, Higuchi M, Miyachi M
  • Journal Title: Physiol Genomics Volume: 43 Pages: 103-109
  • Peer Reviewed
• [Journal Article] Age and cardiorespiratory fitness are associated with arterial stiffening and left ventricular remodelling. (2010)
  • Author(s): Gando Y, Kawano H, Yamamoto K, Sanada K, Tanimoto M, Oh T, Ohmori Y, Miyatani M, Usui C, Takahashi E, Tabata I, Higuchi M, Miyachi M.
  • Journal Title: J Hum Hypertens 24 Pages: 197-206
• [Journal Article] Longer time spent in light physical activity is associated with reduced arterial stiffness in older adults. (2010)
  • Author(s): Gando Y, Yamamoto K, Murakami H, Ohmori Y, Kawakami R, Sanada K, Higuchi M, Tabata I, Miyachi M.
  • Journal Title: Hypertension 56 Pages: 540-546
• [Journal Article] Lack of carotid stiffening associated with MTHFR 677TT genotype in cardiorespiratory fit adults. (2010)
  • Author(s): Iemitsu M, Murakami H, Sanada K, Yamamoto K, Kawano H, Gando Y, Miyachi M.
  • Journal Title: Physiol Genomics 42 Pages: 259-265
• [Journal Article] Greater forearm venous compliance in resistance-trained men. (2010)
  • Author(s): Kawano H, Tanimoto M, Yamamoto K, Gando Y, Sanada K, Tabata I, Higuchi M, Miyachi M.
  • Journal Title: Eur J Appl Physiol 110 Pages: 769-777
• [Journal Article] METs in adults while playing active video games : a metabolic chamber study. (2010)
  • Author(s): Miyachi M, Yamamoto K, Ohkawara K, Tanaka S.
  • Journal Title: Med Sci Sports Exerc 42 Pages: 1149-1153
• [Journal Article] A cross-sectional study of sarcopenia in Japanese men and women : reference values and association with cardiovascular risk factors. (2010)
  • Author(s): Sanada K, Miyachi M, Tanimoto M, Yamamoto K, Murakami H, Okumura S, Gando Y, Suzuki K, Tabata I, Higuchi M.
  • Journal Title: Eur J Appl Physiol 110 Pages: 57-65
• [Journal Article] 日本人成人男女を対象としたサルコペニア簡易評価法の開発 (2010)
  • Author(s): 真田樹義, 宮地元彦, 山元健太, 村上晴香, 谷本道哉, 大森由実, 河野寛, 丸藤祐子, 塙智史, 家光素行, 田畑泉, 樋口満, 奥村重年
  • Journal Title: 体力科学 59 Pages: 291-302
  • NAID: 10030691923
• [Journal Article] Longer time spent in light physical activity is associated with reduced arterial stiffness in older adults (2010)
  • Author(s): Gando Y, Yamamoto K, Murakami H, Ohmori Y, Kawakami R, Sanada K, Higuchi M, Tabata I, Miyachi M.
  • Journal Title: Hypertension Volume: 56 Pages: 540-546
  • Peer Reviewed
• [Journal Article] Lack of carotid stiffening associated with MTHFR 677TT genotype in cardiorespiratory fit adults (2010)
  • Author(s): Iemitsu M, Murakami H, Sanada K, Yamamoto K, Kawano H, Gando Y, Miyachi M
  • Journal Title: Physiol Genomics Volume: 42 Pages: 259-265
  • Peer Reviewed
• [Journal Article] Greater forearm venous compliance in resistance-trained men (2010)
  • Author(s): Kawano H, Tanimoto M, Yamamoto K, Gando Y, Sanada K, Tabata I, Higuchi M, Miyachi M
  • Journal Title: Eur J Appl Physiol Volume: 110 Pages: 769-777
  • Peer Reviewed
• [Journal Article] METs in adults while playing active video games : a metabolic chamber study (2010)
  • Author(s): Miyachi M, Yamamoto K, Ohkawara K, Tanaka S
  • Journal Title: Med Sci Sports Exerc Volume: 42 Pages: 1149-1153
  • Peer Reviewed
• [Journal Article] A cross-sectional study of sarcopenia in Japanese men and women : reference values and association with cardiovascular risk factors (2010)
  • Author(s): Sanada K, Miyachi M, Tanimoto M, Yamamoto K, Murakami H, Okumura S, Gando Y, Suzuki K, Tabata I, Higuchi M
  • Journal Title: Eur J Appl Physiol Volume: 110 Pages: 57-65
  • Peer Reviewed
• [Journal Article] 日本人成人男女を対象としたサルコペニア簡易評価法の開発 (2010)
  • Author(s): 真田樹義, 宮地元彦, 山元健太, 村上晴香, 谷本道哉, 大森由実, 河野寛, 丸藤祐子, 塙智史, 家光素行, 田畑泉, 樋口満, 奥村重年
  • Journal Title: 体力科学 Volume: 59 Pages: 291-302
  • NAID: 10030691923
  • Peer Reviewed
• [Journal Article] Age and cardiorespiratory fitness are associated with arterial stiffeningand left ventricular remodelling. (2010)
  • Author(s): Gando Y, Kawano H, Yamamoto K, Sanada K, Tanimoto M, Oh T, Ohmori Y, Miyatani M, Usui C, Takahashi E, Tabata I, Higuchi M, Miyachi M.
  • Journal Title: Journal of Human Hypertension 24 Pages: 197-206
  • Peer Reviewed
• [Journal Article] Low-intensity resistance training with slow movement and tonic force generation increases basal limb blood flow. (2009)
  • Author(s): Tanimoto M, Kawano H, Gando Y, Sanada K, Yamamoto K, Ishii N, Tabata I, Miyachi M.
  • Journal Title: Clin Physiol Funct Imaging 29 Pages: 128-135
• [Journal Article] Differences in body composition and risk of lifestyle-related diseases between young and older male rowers and sedentary controls. (2009)
  • Author(s): Sanada K, Miyachi M, Tabata I, Suzuki K, Yamamoto K, Kawano H, Usui C, Higuchi M.
  • Journal Title: J Sports Sci 27 Pages: 1027-1034
• [Journal Article] Muscle mass and bone mineral indices : does the normalized bone mineral content differ with age? (2009)
  • Author(s): Sanada K, Miyachi M, Tabata I, Miyatani M, Tanimoto M, Oh TW, Yamamoto K, Usui C, Takahashi E, Kawano H, Gando Y, Higuchi M.
  • Journal Title: Eur J Clin Nutr 63 Pages: 465-472
• [Journal Article] Poor trunk flexibility is associated with arterial stiffening. (2009)
  • Author(s): Yamamoto K, Kawano H, Gando Y, Iemitsu M, Murakami H, Sanada K, Tanimoto M, Ohmori Y, Higuchi M, Tabata I, Miyachi M.
  • Journal Title: Am J Physiol Heart Circ Physiol 297 Pages: 1314-1318
• [Journal Article] Poor trunk flexibility is associated with arterial stiffening (2009)
  • Author(s): Yamamoto K, Kawano H, Gando Y, Iemitsu M, Murakami H, Sanada K, Tanimoto M, Ohmori Y, Higuchi M,Tabata I, Miyachi M.
  • Journal Title: American Journal of Physiology 297
  • Peer Reviewed
• [Journal Article] Low-intensity resistance training with slow movement and tonic force generation increases basal limb blood flow (2009)
  • Author(s): Tanimoto M, Kawano H, Gando Y, Sanada K, Yamamoto K, Ishii N, Tabata I, Miyachi M.
  • Journal Title: Clinical Physiology and Functional Imaging 29 Pages: 128-35
  • Peer Reviewed
• [Journal Article] Differences in body composition and risk of lifestyle-related diseases between young and older male rowers and sedentary controls (2009)
  • Author(s): Sanada K, Miyachi M, Tabata I, Suzuki K, Yamamoto K, Kawano H, Usui C, Higuchi M.
  • Journal Title: Journal of Sports Sciences 27 Pages: 1027-34
  • Peer Reviewed
• [Journal Article] Muscle mass and bone mineral indices : does the normalized bone mineral content differ with age? (2009)
  • Author(s): Sanada K, Miyachi M, Tabata I, Miyatani M, Tanimoto M, Oh TW, Yamamoto K, Usui C, Takahashi E, Kawano H, Gando Y, Higuchi M.
  • Journal Title: European Journal of Clinical Nutrition 63 Pages: 465-72
  • Peer Reviewed
• [Journal Article] METs In Adults While Playing Active Video Games : A Metabolic Chamber Study
  • Author(s): Miyachi M, Yamamoto K, OhkawaraK, Tanaka S.
  • Journal Title: Medicine and Science in Sports and Exercise (In Press)
  • Peer Reviewed
• [Presentation] High level of cardirorespiratory fitness is associated with reduced age-related carotid artery remodeling (2010)
  • Author(s): Gando Y, Kawano H, Yamamoto K, Murakami H, Ohmori Y, Kawakami R, Sanada K, Higuchi M, Tabata I, Miyachi M
  • Organizer: American Society of Hypertension 25th Annual Scientific Meeting and Exposition.
  • Place of Presentation: New York, USA.
• [Presentation] Cardiorespiratory fitness affects polymorphism in MTHFR C677T-caused increase in arterial stiffness (2010)
  • Author(s): Iemitsu M, Murakami H, Sanada K, Yamamoto K, Kawano H, Gando Y, Miyachi M
  • Organizer: 15th Annual Congress of the European College of Sport Science.
  • Place of Presentation: Antalya, Turkey.
• [Presentation] Sarcopenic-obesity and metabolic syndrome show comparable results in the effects of cardiovascular risk factors among Japanese elderly people (2010)
  • Author(s): Sanada K, Miyachi M, Iemitsu M, Murakami H, Yamamoto K, Gando Y, Tanimoto M, Tabata I
  • Organizer: 57th Annual Meeting of the American College of Sports Medicine.
  • Place of Presentation: Baltimore, USA.
• [Presentation] 3次元加速度計を用いた身体活動量および心肺体力と動脈硬化との関係 (2009)
  • Author(s): 丸藤祐子、山元健太、村上晴香、川上諒子、谷本道哉、塙智史、田中憲子、田畑泉、樋口満、宮地元彦
  • Organizer: 日本体力医学会
  • Place of Presentation: 新潟
  • Year and Date: 2009-09-20
• [Presentation] 筋発揮張力維持法(LST)を用いた筋力トレーニングが安静時代謝量に与える影響 (2009)
  • Author(s): 谷本道哉、真田樹義、河野寛、丸藤祐子、山元健太、田畑泉、宮地元彦
  • Organizer: 第64回日本体力医学会大会
  • Place of Presentation: 新潟
  • Year and Date: 2009-09-19
• [Presentation] 体力レベルの違いが動脈stiffnessとMTHFR遺伝子多型の関係に及ぼす影響 (2009)
  • Author(s): 家光素行、村上晴香、真田樹義、山元健太、河野寛、丸藤祐子、谷本道哉、田畑泉、宮地元彦
  • Organizer: 第64回日本体力医学会大会
  • Place of Presentation: 新潟
  • Year and Date: 2009-09-19
• [Presentation] 血中ホモシステイン濃度と脚伸展パワーとMTHFR遺伝子多型との関連 (2009)
  • Author(s): 村上晴香、家光素行、真田樹義、谷本道哉、田中憲子、塙智史、山元健太、丸藤祐子、川上諒子、宮地元彦
  • Organizer: 第64回日本体力医学会
  • Place of Presentation: 新潟
  • Year and Date: 2009-09-18
• [Presentation] 習慣的な筋力トレーニングと前腕静脈コンプライアンスとの関係 (2009)
  • Author(s): 河野寛、谷本道哉、山元健太、丸藤祐子、真田樹義、樋口満、宮地元彦
  • Organizer: 第64回日本体力医学会大会
  • Place of Presentation: 新潟
  • Year and Date: 2009-09-18
• [Presentation] Reference value and prediction model of sarcopenia in Japanese men and women (2009)
  • Author(s): Sanada K、Miyachi M、Yamamoto K、Higuchi K、Tabata I
  • Organizer: 56th Annual Meeting, American College of Sports and Medicine : 41 (5) : S595
  • Place of Presentation: Seatle, WA, USA
  • Year and Date: 2009-05-31
• [Presentation] Attenuated age-related increase in carotid intima-media thickness in cardiorespiratory fit men and women (2009)
  • Author(s): Miyachi M、Sanada K、Gando Y、Yamamoto K、Murakami H、Tanimoto M、Ohmori Y、Tabata I
  • Organizer: 56th Annual meeting, American College of Sports and Medicine : 41 (5): S246
  • Place of Presentation: Seatle, WA, USA
  • Year and Date: 2009-05-27
• [Presentation] Energy Expenditure in Adults When Playing Next-generation Video Games (2009)
  • Author(s): Miyachi M, Yamamoto K, Ohkawara K, Tanaka S
  • Organizer: A Metabolic Chamber Study : American Heart Association Scientific Session 2009.
  • Place of Presentation: Florida, USA.