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Regulatory mechanism of insulin secretion system by coenzyme Q_<10>

Research Project

Project/Area Number 21700709
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Applied health science
Research InstitutionKobe Gakuin University

Principal Investigator

OKUNO Masaaki  Kobe Gakuin University, 薬学部, 助教 (40359790)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsコエンザイムQ10 / 糖尿病 / インスリン分泌 / 酸化ストレス / 膵ss細胞 / アポトーシス / 抗酸化作用 / ATP / 膵β細胞 / コエンザイムQ_<10>
Research Abstract

Coenzyme Q10 (CoQ_<10>) is the endogenous substance possessing 2 physiological actions : ATP production-activating and antioxidative actions. Both actions are assumed to play important roles in the exhibition and maintenance of pancreatic ss-cell function. To demonstrate this hypothesis, the role of CoQ10 in the insulin secretion system was investigated.
When sodium selenite was added at a high concentration to induce oxidative stress in RIN5F cells, a rat-derived pancreatic ss-cell line, most cells died within 24 hours. However, when cells were pretreated with CoQ10, this cytopathy was markedly inhibited. When the CoQ10 synthesis pathway was enhanced or inhibited, the expression of genes involved in insulin secretion altered. On the other hand, the CoQ10 content was decreased in the pancreas of type 1 diabetic rats in which pancreatic ss-cells were partially destroyed induced by streptozototocin, but it returned close to the normal level in animals in which the diabetic condition was improved. These findings suggest that CoQ10 plays an important role in the protection of pancreatic ss-cells and the insulin secretion system.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (11 results)

All 2010 2009

All Presentation (11 results)

  • [Presentation] コエンザイムQ10による白内障発症予防効果とその作用機序2010

    • Author(s)
      奥野正顕、武智大志、藤田翔、高橋隆幸、岡本正志
    • Organizer
      第1回アンチエイジング研究会
    • Place of Presentation
      神戸学院大学(兵庫)
    • Year and Date
      2010-08-12
    • Related Report
      2010 Final Research Report
  • [Presentation] コエンザイムQ10による白内障発症予防効果とその作用機序2010

    • Author(s)
      奥野正顕
    • Organizer
      第一回 アンチエイジング研究会
    • Place of Presentation
      神戸学院大学
    • Year and Date
      2010-08-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] コエンザイムQ10による白内障発症予防効果とその作用機序2010

    • Author(s)
      奥野正顕、藤田翔、武智大志、岡本正志
    • Organizer
      第62回日本ビタミン学会
    • Place of Presentation
      いわて県民情報交流センター(岩手)
    • Year and Date
      2010-06-12
    • Related Report
      2010 Final Research Report
  • [Presentation] コエンザイムQ10による白内障発症予防効果とその作用機序2010

    • Author(s)
      奥野正顕
    • Organizer
      第62回 日本ビタミン学会
    • Place of Presentation
      いわて県民情報交流センター
    • Year and Date
      2010-06-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] コエンザイムQ10による白内障発症予防効果2010

    • Author(s)
      奥野正顕、藤田翔、武智大志、岡本正志
    • Organizer
      日本コエンザイムQ協会第7回研究会
    • Place of Presentation
      東京工科大学(東京)
    • Year and Date
      2010-01-26
    • Related Report
      2010 Final Research Report
  • [Presentation] コエンザイムQ10による白内障発症予防効果2010

    • Author(s)
      奥野正顕
    • Organizer
      日本コエンザイムQ協会 第7回研究会
    • Place of Presentation
      東京工科大学
    • Year and Date
      2010-01-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] コエンザイムQ10による白内障発症予防効果2009

    • Author(s)
      奥野正顕、藤田翔、武智大志、岡本正志
    • Organizer
      第59回日本薬学会近畿支部総会・大会
    • Place of Presentation
      近畿大学(大阪)
    • Year and Date
      2009-10-24
    • Related Report
      2010 Final Research Report
  • [Presentation] コエンザイムQ10による白内障発症予防効果2009

    • Author(s)
      奥野正顕
    • Organizer
      第59回日本薬学会近畿支部総会・大会
    • Place of Presentation
      近畿大学
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] コエンザイムQ10による白内障発症防御作用2009

    • Author(s)
      奥野正顕、藤田翔、武智大志、高橋隆幸、紀氏健雄、岡本正志
    • Organizer
      第324回脂溶性ビタミン総合研究委員会
    • Place of Presentation
      神戸学院大学(兵庫)
    • Year and Date
      2009-07-10
    • Related Report
      2010 Final Research Report
  • [Presentation] コエンザイムQ10による白内障発症防御作用2009

    • Author(s)
      奥野正顕
    • Organizer
      第324回脂溶性ビタミン総合研究委員会
    • Place of Presentation
      神戸学院大学
    • Year and Date
      2009-07-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Distribution of Oxidized and Reduced Forms of Coenzyme Q Homologues in Japanese Foods2009

    • Author(s)
      M.Okuno, A.Kettawan, C.Kunthida, S.Fujita, D.Takechi, T.Takahashi, T.Kishi, T.Okamoto
    • Organizer
      8th International Food Data Conference
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2010 Final Research Report 2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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