Primary Prevention of Metabolic Syndrome : Aging-related gene with Reactive Oxygen Species
| Project/Area Number |
21700754
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Nara Women's University |
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Principal Investigator |
NEGISHI Hiroko 奈良女子大学, 大学院人間文化研究科, 助教 (50523841)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | メタボリックシンドローム / UCP2 / 活性酸素種 / NOS / イソフラボン / 疾患モデル動物 / PPARs / プエラリン / 葛 / 3T3 / イソフラボノイド / Sirt1 / モデル動物 / 葛蔓(くずまん) / エストロゲン様作用 / 抗酸化作用 / NADPHオキシダーゼ / NO / 酸化ストレス / 脱共役タンパク質 / 一酸化窒素 / 一次予防 / 内臓脂肪型肥満 / 腎障害 |
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| Research Abstract |
Metabolic syndrome (MS) is associated with overproduction of reactive oxygen species (ROS). The increase of UCP2mRNA expression may depend on increased oxdative stress in SHRSP.Z-Lepr^<fa/>Izm Dmcr rats (SP・ZF). The increase of UCP2 mRNA expression may relate to the phenotype in metabolic syndrome status in SP・ZF. We observed that kudzu extracts could decrease body weight, blood pressure, and serum lipids significantly by increasing UCPs, PPARs.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Caffeic Acid Phenethyl Ester Suppresses the Production of Adipocytokines, Leptin, Tumor Necrosis Factor -Alpha and Resistin, during Differentiation to Adipocytes in 3T3-L1 Cells2011
Author(s)
S. Juman, N. Yasui, H. Okuda, A. Ueda, H. Negishi, T. Miki, and K. Ikeda
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Journal Title
Biological and Pharmaceutical Bulletin
Volume: 34
Issue: 4
Pages: 490-494
DOI
NAID
ISSN
0918-6158, 1347-5215
Related Report
Peer Reviewed
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