Protective effects of rutin against toxicant-induced memory dysfunction and elucidation of the molecular mechanisms

Research Project

Project/Area Number	21700758
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Eating habits, studies on eating habits
Research Institution	Tokyo Health Care University (2010) University of Miyazaki (2009)
Principal Investigator	KODA Tomoko Tokyo Health Care University, 看護学部, 講師 (30391098)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords	食品 / 神経科学
Research Abstract	Rutin is one of flavonoids and buckwheat is known as a major source of rutin. We demonstrated that oral administration of rutin has a protective effect against trimethyltin (TMT)-induced memory dysfunction in rats. Furthermore, we suggested that anti-inflammatory function of rutin revealed protective effects against TMT-induced neuron loss in the hippocampus which plays an important role in memory using cellular and molecular biological techniques.