Protective effects of rutin against toxicant-induced memory dysfunction and elucidation of the molecular mechanisms
Project/Area Number |
21700758
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Eating habits, studies on eating habits
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Research Institution | Tokyo Health Care University (2010) University of Miyazaki (2009) |
Principal Investigator |
KODA Tomoko Tokyo Health Care University, 看護学部, 講師 (30391098)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
|
Keywords | 食品 / 神経科学 |
Research Abstract |
Rutin is one of flavonoids and buckwheat is known as a major source of rutin. We demonstrated that oral administration of rutin has a protective effect against trimethyltin (TMT)-induced memory dysfunction in rats. Furthermore, we suggested that anti-inflammatory function of rutin revealed protective effects against TMT-induced neuron loss in the hippocampus which plays an important role in memory using cellular and molecular biological techniques.
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Report
(3 results)
Research Products
(2 results)