Role of fatty acid for brain development during fetal period.

• Project/Area Number: 21700759
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Eating habits, studies on eating habits
• Research Institution: Nayoro City University
• Principal Investigator: YAMAMOTO Taturou Nayoro City University, 保健福祉学部, 講師 (90379389)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: n-3系多価不飽和脂肪酸 / 脂質栄養 / 生後脳発達 / 大脳皮質 / グリア細胞 / アストロサイト / オリゴデンドロサイト / 髄鞘構築 / DHA / 脂肪酸 / 胎生期脂質栄養 / 神経新生 / 神経回路網 / 母指栄養 / 軸索伸長 / リーリン / 大脳皮質構築

Research Abstract

n-3 PUFAs plays an important role in brain. To understand the effect of maternal intake of n-3 PUFAs against postnatal macroglia development in the brain of P0, P7 and P14.We performed several morphological studies of the cerebral cortices in these pups. Our data suggest that appropriate intake of n-3 PUFAs is important for postnatal glial development.

Research Products

• [Journal Article] Histological study in the brain of the reelin/Dabl-compound mutant mouse. (2009)
  • Author(s): Yamamoto T, et al.
  • Journal Title: Anatomical Science International 84(3) Pages: 200-209
  • Peer Reviewed
• [Journal Article] Taurine feeding indibits bile acid absorption from the ileum in rats fed a high cholesterol and high fat diet. (2009)
  • Author(s): Nishimura N, et al.
  • Journal Title: Advances in Experimental Medicine and Biology 643 Pages: 258-291
  • Peer Reviewed
• [Presentation] Maternal dietary n-3 PUFAs affects development of glial cells in the infant brain (2011)
  • Author(s): Tatsuro Yamamoto, Ayako Okuyama-Yamamoto, Ayuko Moriuchi, Hiroki Tanabe, Naomichi Nishimura
  • Organizer: 第116回日本解剖学会総会 P3-P173
  • Place of Presentation: 順天堂大学/東京
  • Year and Date: 2011-03-30
• [Presentation] Maternal dietary n-3 PUFAs affects development of glial cells in the infant brain (2011)
  • Author(s): 山本達朗
  • Organizer: 第116回日本解剖学会総会
  • Place of Presentation: パシフィコ横浜(東北震災により誌上開催)
  • Year and Date: 2011-03-30
• [Presentation] 妊娠前後の期間における食餌性脂肪酸組成は母胎の情動および母性行動に影響を与える. (2010)
  • Author(s): 山本達朗
  • Organizer: 第115回日本解剖学会総会
  • Place of Presentation: 岩手県民会館
  • Year and Date: 2010-03-30
• [Presentation] Role of n-3 PUFAs in the brain developmen (2009)
  • Author(s): 山本達朗
  • Organizer: 32nd Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2009-09-17
• [Remarks] ホームページ等