Effect of plant polyphenols on oxidative stress and lipid metabolism in pregnancy-induced hypertension rat models
| Project/Area Number |
21700760
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Aomori University of Health and Welfare |
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Principal Investigator |
MUKAI Yuuka 青森県立保健大学, 健康科学部, 助教 (60331211)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 妊娠高血圧症候群 / アズキポリフェノール / 酸化ストレス / 血液凝固線溶系 / 胎盤 / 胎児 / フルクトース / 脂質代謝 / 妊娠 / 血糖値 / 一酸化窒素 / 臍帯血管 / 組織型プラスミノーゲン活性化因子 / PAI-1 / TF経路阻害因子 / 植物性ポリフェノール / スーパーオキシドジスムターゼ |
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| Research Abstract |
In order to examine the effect of plant polyphenols on maternal blood pressure, oxidative stress, and glucose and lipid metabolism in pregnancy-induced hypertension rat models, pregnant rats were treated by nitric oxide(NO) synthase inhibitor or excess intake of fructose. In NO-deficient pregnant rats, azuki bean polyphenols up-regulated significantly renal expression of Mn-superoxide dismutase, although significant decrease in maternal blood pressure was not observed. In fructose-fed pregnant rats, azuki bean polyphenols partly diminished hepatic expression of lipogenic transcription factor
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Report
(4 results)
Research Products
(17 results)
