• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Effect of plant polyphenols on oxidative stress and lipid metabolism in pregnancy-induced hypertension rat models

Research Project

Project/Area Number 21700760
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Eating habits, studies on eating habits
Research InstitutionAomori University of Health and Welfare

Principal Investigator

MUKAI Yuuka  青森県立保健大学, 健康科学部, 助教 (60331211)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords妊娠高血圧症候群 / アズキポリフェノール / 酸化ストレス / 血液凝固線溶系 / 胎盤 / 胎児 / フルクトース / 脂質代謝 / 妊娠 / 血糖値 / 一酸化窒素 / 臍帯血管 / 組織型プラスミノーゲン活性化因子 / PAI-1 / TF経路阻害因子 / 植物性ポリフェノール / スーパーオキシドジスムターゼ
Research Abstract

In order to examine the effect of plant polyphenols on maternal blood pressure, oxidative stress, and glucose and lipid metabolism in pregnancy-induced hypertension rat models, pregnant rats were treated by nitric oxide(NO) synthase inhibitor or excess intake of fructose. In NO-deficient pregnant rats, azuki bean polyphenols up-regulated significantly renal expression of Mn-superoxide dismutase, although significant decrease in maternal blood pressure was not observed. In fructose-fed pregnant rats, azuki bean polyphenols partly diminished hepatic expression of lipogenic transcription factor

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (17 results)

All 2012 2011 2010 2009

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (11 results)

  • [Journal Article] Effect of nitric oxide deficiency on tissue-type plasminogen activator expression in the umbilical cord in a pregnancy-induced hypertension rat model2012

    • Author(s)
      Mukai Y, Sato S
    • Journal Title

      Pregnancy Hypertension

      Volume: 2 Issue: 1 Pages: 53-58

    • DOI

      10.1016/j.preghy.2011.10.002

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of lignin-derived lignophenols on vascular oxidative stress and inflammation in streptozotocin-induced diabetic rats2011

    • Author(s)
      Mukai Y, Norikura T, Fujita S, Mikame K, Funaoka M, Sato S
    • Journal Title

      Molecular and Cellular Biochemistry

      Volume: 348 Issue: 1-2 Pages: 117-124

    • DOI

      10.1007/s11010-010-0645-9

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polyphenol-containing azuki bean(Vigna angularis) seed coats attenuate vascular oxidative stress and inflammation in spontaneously hypertensive rats2011

    • Author(s)
      Mukai Y, Sato S
    • Journal Title

      The Journal of Nutritional Biochemistry

      Volume: 222 Issue: 1 Pages: 16-21

    • DOI

      10.1016/j.jnutbio.2009.11.004

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Maternal low-protein diet suppresses vascular and renal endothelial NO synthase phosphorylation in rat offspring independent of a postnatal fructose diet2011

    • Author(s)
      Sato S, Mukai Y, Norikura T
    • Journal Title

      Journal of Developmental Origins of Health and Disease

      Volume: 2 Issue: 3 Pages: 168-175

    • DOI

      10.1017/s2040174411000110

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polyphenol-containing azuki bean(Vigna angularis) extract attenuates blood pressure elevation and modulates nitric oxide synthase and caveolin-1 expressions in rats with hypertension2009

    • Author(s)
      Mukai Y, Sato S
    • Journal Title

      Nutrition, Metabolism & Cardiovascular Diseases

      Volume: 19 Pages: 491-497

    • URL

      http://www.sciencedirect.com/science/article/pii/S0939475308001919

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polyphenol-containing azuki bean (Vigna angularis) extract attenuates blood pressure elevation and modulates nitric oxide synthase and caveolin-1 expressions in rats with hypertension.2009

    • Author(s)
      Mukai Y, Sato S
    • Journal Title

      Nutr Metab Cardiovasc Dis 19

      Pages: 491-497

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 高脂肪食誘発肥満モデルラットの脂質代謝に及ぼすリグノフェノールの影響2012

    • Author(s)
      徳岡友佳里, 向井友花, 佐藤伸
    • Organizer
      2011年度青森県保健医療福祉研究発表会
    • Place of Presentation
      青森
    • Year and Date
      2012-02-18
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 妊娠期低栄養母ラットの授乳期におけるカテキン類摂取が仔ラットの成長後の血圧上昇および一酸化窒素合成酵素の発現に及ぼす影響2012

    • Author(s)
      濱谷舞, 向井友花, 佐藤伸
    • Organizer
      2011年度青森県保健医療福祉研究発表会
    • Place of Presentation
      青森
    • Year and Date
      2012-02-18
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 妊娠期緑茶投与の出産仔のエピゲネチック因子に及ぼす影響2012

    • Author(s)
      孫永., 佐藤伸, 向井友花, 細川敏幸, 齋藤健, 蔵崎正明
    • Organizer
      第82回日本衛生学会学術総会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 妊娠期の一酸化窒素欠乏が臍帯血管における血液線溶系因子tPAの発現に及ぼす影響2011

    • Author(s)
      向井友花, 佐藤伸
    • Organizer
      2010年度青森県保健医療福祉研究発表会
    • Place of Presentation
      青森
    • Year and Date
      2011-02-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 妊娠期の一酸化窒素欠乏が臍帯血管における血液線溶系因子tPAの発現に及ぼす影響2011

    • Author(s)
      向井友花、佐藤伸
    • Organizer
      2010年度青森県保健医療福祉研究発表会
    • Place of Presentation
      青森市
    • Year and Date
      2011-02-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胎生期低蛋白栄養に曝された仔ラットの成長後のAMPキナーゼ活性に及ぼすケルセチンの影響2011

    • Author(s)
      向井友花, 佐藤伸
    • Organizer
      第65回日本栄養・食糧学会大会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 植物リグニン由来リグノフェノールの糖尿病モデルラットの血管障害に及ぼす影響2011

    • Author(s)
      佐藤伸, 向井友花, 乗鞍敏夫, 藤田修三
    • Organizer
      第81回日本衛生学学会
    • Place of Presentation
      東京(東日本大震災のため中止)
    • Related Report
      2011 Final Research Report
  • [Presentation] 高血圧モデルラットの酸化ストレスおよび炎症におけるアズキ(Vigna angularis)ポリフェノールの生理的役割2010

    • Author(s)
      向井友花, 佐藤伸
    • Organizer
      日本ヒューマンケア科学学会第3回学術集会
    • Place of Presentation
      青森
    • Year and Date
      2010-10-23
    • Related Report
      2011 Final Research Report
  • [Presentation] 高血圧モデルラットの酸化ストレスおよび炎症におけるアズキ(Vigna angularis)ポリフェノールの生理的役割2010

    • Author(s)
      向井友花、佐藤伸
    • Organizer
      日本ヒューマンケア科学学会第3回学術集会
    • Place of Presentation
      青森市
    • Year and Date
      2010-10-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Lignophenols suppress vascular oxidative stress and inflammation in streptozotocin-induced diabetic rats2010

    • Author(s)
      向井友花, 乗鞍敏夫, 藤田修三, 三亀啓吾, 舩岡正光, 佐藤伸
    • Organizer
      第42回動脈硬化学会学術集会
    • Place of Presentation
      岐阜
    • Related Report
      2011 Final Research Report
  • [Presentation] リグノフェノールによる糖尿病ラットの血管内酸化ストレスの抑制効果2010

    • Author(s)
      向井友花, 乗鞍敏夫, 藤田修三, 佐藤伸
    • Organizer
      第64回日本栄養・食糧学会大会
    • Place of Presentation
      徳島
    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi