Effect of protein-energy malnutrition on brain function.

• Project/Area Number: 21700763
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Eating habits, studies on eating habits
• Research Institution: Kyoto Prefectural University
• Principal Investigator: KUWAHATA Masashi Kyoto Prefectural University, 生命環境科学研究科, 准教授 (30304512)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 低栄養状態 / アルブミン / 酸化型アルブミン / 低アルブミン血症 / 低栄養 / 認知症

Research Abstract

Hypoalbuminemia was observed in plasma of rats with malnutrition. Levels of albumin mRNA were decreased in both liver and brain of rats with malnutrition. Furthermore, percentage of oxidized albumin within total plasma albumin increased in rats with malnutrition. Albumin is also found in cerebrospinal fluid. The increase of oxidized albumin may influence the brain function.

Research Products

• [Journal Article] Dietary medium-chain triglycerides attenuate hepatic lipid deposition in growing rats with protein malnutrition. (2011)
  • Author(s): Kuwahata, M., Kubota, H., Kido, Y., et al.
  • Journal Title: J.Nutr.Sci.Vitaminol. Vol.57 Pages: 138-143
  • NAID: 10030028800
  • Peer Reviewed
• [Journal Article] Dietary medium-chain triglycerides attenuate hepatic lipid deposition in growing rats with protein malnutrition. (2011)
  • Author(s): Kuwahata, M., et al.
  • Journal Title: J.Nutr.Sci.Vitaminol. Volume: 57 Pages: 138-143
  • NAID: 10030028800
  • Peer Reviewed
• [Journal Article] Type IIc sodium-dependent phosphate transporter regulates calcium metabolism. (2009)
  • Author(s): Segawa, H., et al.
  • Journal Title: J Am Soc Nephrol. Vol.20 Pages: 104-113
  • Peer Reviewed
• [Journal Article] Actin and Vimentin proteins with N-terminal deletion detected in tumor-bearing rat livers induced by intraportal-vein injection of Ha-ras-transfected rat liver cells. (2009)
  • Author(s): Nakamura, Y., et al.
  • Journal Title: Int J Cancer. Vol.124 Pages: 2512-2519
  • Peer Reviewed
• [Journal Article] Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development. (2009)
  • Author(s): Segawa,H., et al.
  • Journal Title: Am J Physiol Renal Physiol. Vol.297
  • Peer Reviewed
• [Journal Article] Effect of branched-chain amino acid supplementation on the oxidized/reduced state of plasma albumin in rats with chronic liver disease.
  • Author(s): Kuwahata, M., Kubota, H., Kido, Y., et al.
  • Journal Title: J.Clin.Biochem.Butr. 印刷中
  • NAID: 130004466672
  • Peer Reviewed
• [Journal Article] 栄養状態によるアルブミン合成の調節機構に関する研究
  • Author(s): 桑波田雅士
  • Journal Title: 日本栄養・食糧学会誌 印刷中
  • Peer Reviewed
• [Journal Article] Effect of branched-chain amino acid supplementation on the oxidized/reduced state of plasma albumin in rats with chronic liver disease.
  • Author(s): Kuwahata, M., et al.
  • Journal Title: J.Clin.Biochem.Nutr. Volume: (印刷中)
  • NAID: 130004466672
  • Peer Reviewed
• [Presentation] BCAA補充栄養療法が慢性肝障害モデルラットのアルブミン酸化還元動態に及ぼす影響 (2011)
  • Author(s): 桑波田雅士, 他3名
  • Organizer: 第65回日本栄養・食糧学会大会
  • Place of Presentation: お茶の水女子大学(東京)
  • Year and Date: 2011-05-15
• [Presentation] 慢性肝疾患モデルラットの肝障害進行に対するBCAA補充栄養療法の有用性 (2011)
  • Author(s): 久保田紘代、桑波田雅士, 他2名
  • Organizer: 第14回日本病態栄養学会年次学術集会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2011-01-16
• [Presentation] 慢性肝疾患モデルラットの肝障害進行に対するBCAA補充栄養療法の有用性 (2011)
  • Author(s): 久保田紘代, 他
  • Organizer: 第14回 日本病態栄養学会 年次学術集会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-01-16
• [Presentation] 栄養状態によるアルブミン合成の調節機構に関する研究 (2010)
  • Author(s): 桑波田雅士
  • Organizer: 第64回日本栄養・食糧学会大会
  • Place of Presentation: アスティとくしま(徳島)
  • Year and Date: 2010-05-21
• [Presentation] 中鎖脂肪酸摂取はクワシオルコルに伴う脂肪肝の発症を抑制する (2009)
  • Author(s): 久保田紘代, ほか
  • Organizer: 第56回日本栄養改善学会学術総会
  • Place of Presentation: 札幌コンベンションセンター(北海道)
  • Year and Date: 2009-09-04
• [Remarks] ホームページ等
  • URL: http://www2.kpu.ac.jp/life_environ/nutrition_sci/