| Project/Area Number |
21700773
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | 公益財団法人がん研究会 (2012)
Mukogawa Women's University (2009-2011) |
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Principal Investigator |
KUNIMASA Kazuhiro 公益財団法人がん研究会, がん化学療法センターゲノム研究部, 研究員 (50534020)
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 血管新生 / 血管内皮細胞 / がん / レスベラトロール / 食品機能 / マイクロアレイ / レスベラトロールオリゴマー / 管腔形成 / 固形がん / がん予防 / シグナル伝達 / 腫瘍 / 細胞遊走 / 癌 / オリゴマー |
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| Research Abstract |
In in vitro angiogenesis models, the melinjo (Gnetum gnemon L.) seed extract and its major component gnetin C, a resveratrol dimer, inhibited multiple angiogenic functions, such as endothelial cell proliferation, migration, and tube formation. The melinjo extract also suppressed tumor angiogenesis, growth, and metastasis in vivo. Furthermore, using a gene expression signature-based approach, the modes of action of the melinjo extract and gnetin C were found to be similar to those of topoisomerase and cyclin-dependent kinase inhibitors
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