| Project/Area Number |
21700780
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | 独立行政法人国立循環器病研究センター (2010)
Hatano Research Institute, Food and Drug Safety Center (2009) |
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Principal Investigator |
NAITO Yukiko 独立行政法人国立循環器病研究センター, 病態ゲノム医学部, 室長 (80426428)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 薬理学 / 脂質 / 循環器・高血圧 / 食品 |
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| Research Abstract |
This study revealed that increase in plasma lipids was involved in a part of mechanism in the shortening of lifespan of stroke prone spontaneously hypertensive rats (SHRSP), one animal model of lifestyle-related disease, fed diet containing 10 w/w% canola oil. This increase, which was observed on and after the early intake period, was inhibited by the combined administration of clofibrate, a PPAR alpha agonist. Additionally, incidences of death and chronic nephropathy were attenuated by the administration. Further studies are needed to elucidate the mechanism of short lifespan induced by canola oil intake, involving the detailed mode of action of clofibrate.
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