Analysis of the molecular mechanisms of acquired radioresistance induced by fractionated radiation

• Project/Area Number: 21710054
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: Tohoku University
• Principal Investigator: SHIMURA Tsutomu Tohoku University, 加齢医学研究所, 助教 (40463799)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 放射線 / がん / 放射線耐性

Research Abstract

We have demonstrated that tumor radioresistance can be suppressed by down-regulation of AKT/GSK3beta/cyclin D1 pathway. Manipulation of cyclin D1 is useful to enhance the efficacy of radiotherapy.

Research Products

• [Journal Article] Targeting the AKT/GSK3b/cyclin D1/Cdk4 survival signaling pathway for eradication of tumor radioresistance acquired by fractionated radiotherapy (2011)
  • Author(s): Shimura T, Kakuda S, Ochiai Y, Kuwahara Y, Takai Y, Fukumoto M.
  • Journal Title: International Journal of Radiation Oncology Biology Physics 80 Pages: 540-548
  • Peer Reviewed
• [Journal Article] Interactions of MCP1 with Components of the Replication Machinery in Mammalian Cells. (2011)
  • Author(s): Bronze-da-Rocha E, Lin CM, Shimura T, Aladjem MI.
  • Journal Title: Int J Biol Sci 7 Pages: 193-208
  • Peer Reviewed
• [Journal Article] Targeting the AKT/GSK3beta/cyclin D1/Cdk4 survival signaling pathway for eradication of tumor radioresistance acquired by fractionated radio therapy (2011)
  • Author(s): Shimura T, et al.
  • Journal Title: International Journal of Radiation Oncology Biology Physics Volume: (未定 印刷中)
  • Peer Reviewed
• [Journal Article] Interactions of MCP1 with Components of the Replication Machinery in Mammalian Cells (2011)
  • Author(s): Bronze-da-Rocha E, Lin CM, Shimura T, Aladjem MI.
  • Journal Title: Int J Biol Sci Volume: 7 Pages: 193-208
  • Peer Reviewed
• [Journal Article] Acquired radioresistance of human tumor cells by DNA-PK/AKT/GSK3beta-mediated cyclin D1 overexpression. (2010)
  • Author(s): Shimura T, Kakuda S, Ochiai Y, Nakagawa H, Kuwahara Y, Takai Y, Kobayashi J, Komatsu K, Fukumoto M.
  • Journal Title: Oncogene 29 Pages: 4826-4837
  • Peer Reviewed
• [Journal Article] X-radiation-induced down-regulation of the EGF receptor in primary cultured rat hepatocytes. (2010)
  • Author(s): Maruko A, Ohtake Y, Kawaguchi M, Kobayashi T, Baba T, Kuwahara Y, Nakagawa H, Shimura T, Fukumoto M, Ohkubo Y.
  • Journal Title: Radiat Res 173 Pages: 620-628
  • Peer Reviewed
• [Journal Article] The modified high-density survival assay is the useful tool to predict the effectiveness of fractionated radiation exposure. (2010)
  • Author(s): Kuwahara Y, Mori M, Oikawa T, Shimura T, Ohtake Y, Mori S, Ohkubo Y, Fukumoto M.
  • Journal Title: J Radiat Res (Tokyo) 51 Pages: 297-302
  • NAID: 10026471144
  • Peer Reviewed
• [Journal Article] Acquired radioresistance of human tumor cells by DNA-PK/AKT/GSK3beta-mediated cyclin D1 overexpression. (2010)
  • Author(s): Shimura T, et al.
  • Journal Title: Oncogene Volume: 29 Pages: 4826-4837
  • Peer Reviewed
• [Journal Article] X-radiation-induced down-regulation of the EGF receptor in primary cultured rat hepatocytes. (2010)
  • Author(s): Maruko A, et al., (前から8番目)
  • Journal Title: Radiat Res Volume: 173 Pages: 620-628
  • Peer Reviewed
• [Journal Article] The modified high-density survival assay is the useful tool to predict the effectiveness of fractionated radiation exposure. (2010)
  • Author(s): Kuwahara, et al., (前から4番目)
  • Journal Title: J Radiat Res (Tokyo) Volume: 100 Pages: 297-302
  • Peer Reviewed
• [Journal Article] Clinically relevant radioresistant cells efficiently repair DNA double-strand breaks induced by X-rays. (2009)
  • Author(s): Kuwahara Y, Li L, Baba T, Nakagawa H, Shimura T, Yamamoto Y, Ohkubo Y, Fukumoto M.
  • Journal Title: Cancer Sci 100 Pages: 747-752
  • NAID: 10025144817
  • Peer Reviewed
• [Presentation] AKT阻害剤とCdk4阻害剤によるヒトがん細胞の放射線耐性の抑制 (2010)
  • Author(s): 志村勉、角田智、落合泰史、桑原義和、高井良尋、福本学
  • Organizer: 日本放射線影響学会
  • Place of Presentation: 京
  • Year and Date: 2010-10-21
• [Presentation] AKT阻害剤とCdk4阻害剤によるヒトがん細胞の放射線耐性の抑制 (2010)
  • Author(s): 志村勉
  • Organizer: 日本放射線影響学会
  • Place of Presentation: 京都
  • Year and Date: 2010-10-21
• [Presentation] DNA-PK/ATK/GSK3β/Cyclin D1経路を標的としたヒトがん細胞の獲得放射線耐性の克服 (2010)
  • Author(s): 志村勉、桑原義和、高井良尋、福本学
  • Organizer: 日本癌学会
  • Place of Presentation: 都
  • Year and Date: 2010-09-24
• [Presentation] DNA-PK/ATK/GSK3beta/Cyclin D1経路を標的としたヒトがん細胞の獲得放射線耐性の克服 (2010)
  • Author(s): 志村勉
  • Organizer: 日本癌学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-24
• [Presentation] DNA-PK/AKT/GSK3b/cyclinD1経路を標的としたヒトがん細胞における放射線耐性の克服 (2009)
  • Author(s): 志村勉、角田智、高井良尋、桑原義和、福本学
  • Organizer: 日本放射線影響学会
  • Place of Presentation: 広島
  • Year and Date: 2009-11-11
• [Presentation] 長期分割放射線被ばくによるがん細胞の放射線耐性の獲得 (2009)
  • Author(s): 志村勉、落合泰史、桑原義和、福本学
  • Organizer: 日本放射線影響学会
  • Place of Presentation: 広島
  • Year and Date: 2009-11-11
• [Presentation] 長期分割放射線被ばくによるがん細胞の放射線耐性の獲得 (2009)
  • Author(s): 志村勉
  • Organizer: 第52回日本放射線影響学会
  • Place of Presentation: 広島
  • Year and Date: 2009-11-11
• [Presentation] DNA-PK/AKT/GSK3b/cyclin D1経路を標的としたヒトがん細胞における放射線耐性の克服 (2009)
  • Author(s): 志村勉
  • Organizer: 第52回日本放射線影響学会
  • Place of Presentation: 広島
  • Year and Date: 2009-11-11
• [Remarks] ホームページ等
  • URL: http://www.idac.tohoku.ac.jp/ja/organization/pathology/index.html