Analysis of the molecular mechanisms of acquired radioresistance induced by fractionated radiation
Project/Area Number |
21710054
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Risk sciences of radiation/Chemicals
|
Research Institution | Tohoku University |
Principal Investigator |
SHIMURA Tsutomu Tohoku University, 加齢医学研究所, 助教 (40463799)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
Keywords | 放射線 / がん / 放射線耐性 |
Research Abstract |
We have demonstrated that tumor radioresistance can be suppressed by down-regulation of AKT/GSK3beta/cyclin D1 pathway. Manipulation of cyclin D1 is useful to enhance the efficacy of radiotherapy.
|
Report
(3 results)
Research Products
(20 results)