The study of clinically relevant radioresistant cells for the development of more effective tumor radiotherapy
| Project/Area Number |
21710055
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 放射線耐性 / オートファジー細胞死 / ラパマイシン / 臨床的放射線耐性 / ドセタキセル / ABCトランスポーター / 血管新生 / RAD001 / 臨床的放射線耐性細胞 / 抗がん剤 |
|---|
| Research Abstract |
X-ray induced autophagic cell death is suppressed in radioresistant cells. Administration of rapamycin, an induced of autophagy, sensitized radioresistant cells. Induction of autophagy would be the effective modality to overcome radioresistant tumor.
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Report
(3 results)
Research Products
(37 results)
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[Journal Article] Enhancement of autophagy is a potential modality for tumors refractory to radiotherapy
Author(s)
Kuwahara Y, Oikawa T, Ochiai Y, Roudkenar MH, Fukumoto M, Shimura T, Ohtake Y, Ohkubo Y, Mori S, Uchiyama Y, Fukumoto M
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Journal Title
Cell Death and Disease
Volume: (in press)
Related Report
Peer Reviewed
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