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Molecular function of radiation-induced mammary carcinoma-related genes/microRNAs in three dimensional culture system

Research Project

Project/Area Number 21710058
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Risk sciences of radiation/Chemicals
Research InstitutionHiroshima University

Principal Investigator

IIZUKA Daisuke  Hiroshima University, 原爆放射線医科学研究所, 助教 (00455388)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords放射線誘発乳がん / 三次元培養 / マイクロRNA / 放射線発がん
Research Abstract

In this study, I focused on radiation-induced mammary carcinoma-related genes/microRNAs, and I analyzed whether these genes/microRNAs formed aberrant mammary ductal structure in three dimensional culture systems. The aberrant mammary ductal structure was not observed by introducing these microRNAs in MCF-10A cells, suggesting that these microRNAs have no function at least on the formation of mammary duct.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (12 results)

All 2010 2009

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (8 results)

  • [Journal Article] DNA copy number aberrations and disruption of the p16Ink4a/Rb pathway in radiation-induced and spontaneous rat mammary carcinomas.2010

    • Author(s)
      Iizuka D., Imaoka T., Takabatake T., Nishimura M., Kakinuma S., Nishimura Y., Shimada Y.
    • Journal Title

      Radiation Research 174(2)

      Pages: 206-215

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] DNA copy number aberrations and disruption of the p16Ink4a/Rb path way in radiation-induced and spontaneous rat mammary carcinomas.2010

    • Author(s)
      Iizuka D., Imaoka T., Takabatake T., Nishimura M., Kakinuma S., Nishimura Y, Shimada Y.
    • Journal Title

      Radiation Research 174(2) : 206-15

      Volume: 174(2) Pages: 206-215

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiation-induced mammary carcinogenesis in rodent models: what's different from chemical carcinogenesis?2009

    • Author(s)
      Imaoka T, Nishimura M, Iizuka D, Daino K, Takabatake T, Okamoto M, Kakinuma S, Shimada Y.
    • Journal Title

      Journal of Radiation Research 50(4)

      Pages: 281-293

    • NAID

      10025911934

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Radiation-induced mammary carcinogenesis in rodent models : what's different from chemical carcinogenesis?2009

    • Author(s)
      Imaoka T, Nishimura M, Iizuka D, Daino K, Takabatake T, Okamoto M, Kakinuma S, Shimada Y.
    • Journal Title

      Radiation Research 50(4)

      Pages: 281-293

    • NAID

      10025911934

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] ラット放射線誘発乳がんに特徴的なマイクロRNA が乳がん細胞株に与える影響2010

    • Author(s)
      飯塚大輔, 今岡達彦, 西村まゆみ, 河合秀彦, 鈴木文男, 島田 義也
    • Organizer
      第53回日本放射線影響学会
    • Place of Presentation
      京都テルサ(京都市)
    • Year and Date
      2010-10-20
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット放射線誘発乳がんに特徴的なマイクロRNAが乳がん細胞株に与える影響2010

    • Author(s)
      飯塚大輔, 今岡達彦, 西村まゆみ, 河合秀彦, 鈴木文男, 島田義也
    • Organizer
      第53回日本放射線影響学会
    • Place of Presentation
      京都テルサ(京都市)
    • Year and Date
      2010-10-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラット放射線誘発乳がんにおけるマイクロRNA 発現の網羅的解析2009

    • Author(s)
      飯塚大輔, 今岡達彦, 西村まゆみ, 高畠貴志, 柿沼志津子, 河合秀彦, 鈴木文男, 島田義也
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2009-12-11
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット放射線誘発乳がんにおけるマイクロRNA発現の網羅的解析2009

    • Author(s)
      飯塚大輔, 今岡達彦, 西村まゆみ, 高畠貴志, 柿沼志津子, 河合秀彦, 鈴木文男, 島田義也
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラット乳がんにおける放射線被ばくに特徴的なマイクロRNA の解析2009

    • Author(s)
      飯塚大輔, 今岡達彦, 西村まゆみ, 高畠貴志, 柿沼志津子, 河合秀彦, 鈴木文男, 島田義也
    • Organizer
      第52回日本放射線影響学会
    • Place of Presentation
      南区民文化センター(広島市)
    • Year and Date
      2009-11-12
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット乳がんにおける放射線被ばくに特徴的なマイクロRNAの解析2009

    • Author(s)
      飯塚大輔, 今岡達彦, 西村まゆみ, 高畠貴志, 柿沼志津子, 河合秀彦, 鈴木文男, 島田義也
    • Organizer
      第52回日本放射線影響学会
    • Place of Presentation
      南区民文化センター(広島市)
    • Year and Date
      2009-11-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 放射線誘発ラット乳がんにおけるmicroRNA 解析2009

    • Author(s)
      飯塚大輔, 今岡達彦, 西村まゆみ, 高畠貴志, 柿沼志津子, 河合秀彦, 鈴木文男, 島田義也
    • Organizer
      第148回日本獣医学会
    • Place of Presentation
      とりぎん文化会館(鳥取市)
    • Year and Date
      2009-09-26
    • Related Report
      2010 Final Research Report
  • [Presentation] 放射線誘発ラット乳がんにおけるmicroRNA解析2009

    • Author(s)
      飯塚大輔, 今岡達彦, 西村まゆみ, 高畠貴志, 柿沼志津子, 河合秀彦, 鈴木文男, 島田義也
    • Organizer
      第148回日本獣医学会
    • Place of Presentation
      とりぎん文化会館(鳥取市)
    • Year and Date
      2009-09-26
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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