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Construction of Separation Systems for Biomacromolecules by Using Self-Organized Nanotube Hydrogels

Research Project

Project/Area Number 21710117
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Nanomaterials/Nanobioscience
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

KAMETA Naohiro  National Institute of Advanced Industrial Science and Technology, ナノチューブ応用研究センター研, 研究員 (20517297)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsナノ材料 / 自己組織化 / ナノチューブ / ハイドロゲル / DNA / 分離 / ナノチューブハイドロゲル / ナノチャネル / 光刺激応答性 / キャピラリー電気泳動 / 拡散係数 / 超分子 / pH刺激応答 / 光刺激応答 / 1次元中牢シリンダー / 3次元網目空間 / 生体高分子
Research Abstract

Novel wedge-shaped amphiphiles self-organized in water to from nanotube hydrogels responding on pH stimulus. The nanotube hydrogel possessed two independent spaces consisting of three-dimensional meshworks formed between nanotubes and one-dimensional hollow cylinder of the nanotube itself. Introduction of the nanotube hydrogel as sieves into the capillary electrophoresis allowed to construct a separation system for biomacromolecules. Imaging technique showed that the one-dimensional hollow cylinder of the nanotube with 8 nm inner diameter acts as a functional space for the DNA separation.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (27 results)

All 2011 2010 2009 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (15 results) Remarks (3 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Liquid-Phase Nanospace Chemistry of Self-Organized Nanotube Channels2011

    • Author(s)
      Naohiro Kameta
    • Journal Title

      Bunseki Kagaku

    • NAID

      130001086676

    • Related Report
      2010 Annual Research Report 2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Photo-Responsive Soft Nanotubes for Controlled Guest Release2011

    • Author(s)
      Naohiro Kameta, Asuka Tanaka, Haruhisa Akiyama, Hiroyuki Minamikawa, Mitsutoshi Masuda, Toshimi Shimizu
    • Journal Title

      Chemistry-A European Journal vol.17

      Pages: 5251-5255

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Photo-Responsive Soft Nanotubes for Controlled Guest Release2011

    • Author(s)
      Naohiro Kameta
    • Journal Title

      Chemistry-A European Journal

      Volume: 17 Pages: 5251-5255

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Confinement Effect of Organic Nanotubes Toward Green Fluorescent Proteins (GFP) Depending on the Inner Diameter Size2010

    • Author(s)
      Naohiro Kameta, Hiroyuki Minamikawa, Yuu Someya, Hiroharu Yui, Mitsutoshi Masuda, Toshimi Shimizu
    • Journal Title

      Chemistry-A European Journal,インサイドカバー, Very Important Paper vol.16

      Pages: 4217-4223

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Confinement Effect of Organic Nanotubes Toward Green Fluorescent Protein (GFP) Depending on the Inner Diameter Size2010

    • Author(s)
      Naohiro Kameta
    • Journal Title

      Chemistry A European Journal 16

      Pages: 4217-4223

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Supramolecular Nanotube Hydrogels : Remarkable Resistance Effect of Confined Proteins to Denaturants2009

    • Author(s)
      Naohiro Kameta, Kaname Yoshida, Mitsutoshi Masuda, Toshimi Shimizu
    • Journal Title

      Chemistry of Materials vol.21

      Pages: 5892-5898

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Supramolecular Nanotube Hydrogels : Remarkable Resistance Effect of Confined Proteins to Denaturants2009

    • Author(s)
      Naohiro Kameta
    • Journal Title

      Chemistry of Materials 21

      Pages: 5892-5898

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Organic Nanotubes with a Confinement Nanospace for Biomacromolecules2011

    • Author(s)
      Naohiro Kameta, Mitsutoshi Masuda, Toshimi Shimizu
    • Organizer
      International Conference on Biomaterials Science 2011
    • Place of Presentation
      つくば
    • Year and Date
      2011-03-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Organic Nanotubes with a Confinement Nanospace for Biomacromolecules2011

    • Author(s)
      Naohiro Kameta
    • Organizer
      International Conference on Biomaterials Science (ICBS) 2011
    • Place of Presentation
      茨城
    • Year and Date
      2011-03-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Supramolecular Nanotube Hydrogels Having a One-Dimensional Confined Nanospace and Three-Dimensional Meshworks for Proteins2010

    • Author(s)
      Naohiro Kameta, Mitsutoshi Masuda, Toshimi Shimizu
    • Organizer
      Pacifichem2010
    • Place of Presentation
      ハワイ
    • Year and Date
      2010-12-17
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 有機ナノチューブのナノ空間化学(5):ゲスト放出制御のための光刺激応答性ナノチューブの構築2010

    • Author(s)
      亀田直弘, 田中明日香, 秋山陽久, 南川博之, 増田光俊, 清水敏美
    • Organizer
      第59回高分子学会年次大会
    • Place of Presentation
      横浜
    • Year and Date
      2010-05-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 有機ナノチューブのナノ空間化学(5):ゲスト放出制御のための光刺激応答性ナノチューブの構築2010

    • Author(s)
      亀田直弘
    • Organizer
      第59回高分子学会年次大会
    • Place of Presentation
      神奈川
    • Year and Date
      2010-05-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 有機ナノチューブのナノ空間化学(8):ゲストタンパク質の輸送拡散,放出速度,安定性に及ぼすナノチャネルの内径効果2010

    • Author(s)
      亀田直弘, 南川博之, 増田光俊, 清水敏美
    • Organizer
      第71回分析化学討論会
    • Place of Presentation
      島根
    • Year and Date
      2010-05-16
    • Related Report
      2010 Final Research Report
  • [Presentation] 有機ナノチューブのナノ空間化学(8):ゲストタンパク質の輸送拡散、放出速度、安定性に及ぼすナノチャネルの内径効果2010

    • Author(s)
      亀田直弘
    • Organizer
      第71回分析化学討論会
    • Place of Presentation
      島根
    • Year and Date
      2010-05-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 有機ナノチューブのナノ空間化学(1):光刺激応答性ナノチューブの創製とゲスト放出制御2010

    • Author(s)
      亀田直弘, 田中明日香, 秋山陽久, 南川博之, 増田光俊, 清水敏美
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 有機ナノチューブのナノ空間化学(1):光刺激応答性ナノチューブの創製とゲスト放出制御2010

    • Author(s)
      亀田直弘
    • Organizer
      第58回高分子討論会
    • Place of Presentation
      近畿大学(大阪)
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 有機ナノチューブ空間のバイオ応用(1):ナノチャネルに包接された生体高分子の動的挙動と安定性2010

    • Author(s)
      亀田直弘, 南川博之, 増田光俊, 清水敏美
    • Organizer
      SORSTシンポジウム(4)ナノ空間材料その特性と魅力
    • Place of Presentation
      東京
    • Year and Date
      2010-01-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 有機ナノチューブ空間のバイオ応用(1)ナノチャネルに包接された生体高分子の動的挙動と安定性2010

    • Author(s)
      亀田直弘
    • Organizer
      SORSTシンポジウム(4)ナノ空間材料その特性と魅力
    • Place of Presentation
      コクヨホール(東京都)
    • Year and Date
      2010-01-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] Supramolecular Nanotube Hydrogel2009

    • Author(s)
      Naohiro Kameta, Kaname Yoshida, Mitsutoshi Masuda, Toshimi Shimizu
    • Organizer
      GelSympo2009
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Supramolecular Nanotube Hydrogel2009

    • Author(s)
      Naohiro Kameta
    • Organizer
      GelSympo2009
    • Place of Presentation
      関西大学(大阪)
    • Year and Date
      2009-12-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 超分子ナノチューブハイドロゲルの構築とタンパク質固定化特性2009

    • Author(s)
      亀田直弘, 吉田要, 増田光俊, 清水敏美
    • Organizer
      第58回高分子討論会
    • Place of Presentation
      熊本
    • Year and Date
      2009-09-16
    • Related Report
      2010 Final Research Report
  • [Presentation] 超分子ナノチューブハイドロゲルの構築とタンパク質固定化特性2009

    • Author(s)
      亀田直弘
    • Organizer
      第58回高分子討論会
    • Place of Presentation
      熊本大学(熊本)
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://unit.aist.go.jp/ntrc/ci/index.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://unit.aist.go.jp/ntrc/ci/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://unit.aist.go.jp/ntrc/ci/index.html

    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 光異性化基を有するアミド化合物及び該化合物が自己集合してなる有機ナノチューブ並びにその製造方法2010

    • Inventor(s)
      亀田直弘, 増田光俊, 南川博之, 小木曽真樹, 秋山陽久, 清水敏美
    • Industrial Property Rights Holder
      独立行政法人産業技術総合研究所
    • Industrial Property Number
      2009-198319
    • Filing Date
      2010-08-28
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 光異性化基を有するアミド化合物及び該化合物が自己集合してなる有機ナノチューブ並びにその製造方法2009

    • Inventor(s)
      亀田直弘
    • Industrial Property Rights Holder
      独立行政法人産業技術総合研究所
    • Industrial Property Number
      2009-198319
    • Filing Date
      2009-08-28
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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