Identification of the genetic factor against influenza virus infection in the chicken MHC region.
| Project/Area Number |
21710204
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied genomics
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| Research Institution | National Institute of Genetics (2010)
Tokai University (2009) |
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Principal Investigator |
HOSOMICHI Kazuyoshi National Institute of Genetics, 総合遺伝研究系, 助教 (50420948)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | ニワトリ / MHC / ゲノム / 多様性 / SNP / トリインフルエンザ |
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| Research Abstract |
The chicken MHC (MHC-B) is one of the research interests because of the strong associations with avian influenza virus infection identified in particular MHC-B haplotypes. Because sequence data of MHC-B haplotypes have been lacking, efforts to systematically resolve which genes within the MHC-B region contribute to well-defined MHC-B-associated disease responses was hampering. To indetify the genetic factor against influenza virus infection in the MHC-B region, we determined the complete genomic sequence of 2 MHC-B haplotypes across a region of 220kb encompassing 34 gene loci ranging from KIFC1 to C4.
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Report
(3 results)
Research Products
(54 results)
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[Journal Article] Exact break point of a 50 kb deletion 8 kb centromeric of the HLA-A locus with HLA-A*24:02: the same deletion observed in other A*24 alleles and A*23:01 allele.2011
Author(s)
Mitsunaga S, Okudaira Y, Kunii N, Cui T, Hosomichi K, Oka A, Suzuki Y, Homma Y, Sato S, Inoue I, Inoko H.
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Journal Title
Immunogenetics. In press.
Related Report
Peer Reviewed
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[Journal Article] Basic characterization of 90 kDa heat shock protein genes HSP90AA1, HSP90AB1, HSP90B1 and TRAP1 expressed in Japanese quail (Coturnix japonica).2010
Author(s)
Nagahori K, Iwamoto S, Maruyama A, Suzuki S, Hosomichi K, Shiina T, Hara H, Yoshida Y, Hanzawa K.
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Journal Title
Anim Sci J. 81(4)
Pages: 513-518
NAID
Related Report
Peer Reviewed
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[Journal Article] MHC class I A loci polymorphism and diversity in three Southeast Asian populations of cynomolgus macaque.2009
Author(s)
Kita YF, Hosomichi K, Kohara S, Itoh Y, Ogasawara K, Tsuchiya H, Torii R, Inoko H, Blancher A, Kulski JK, Shiina T.
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Journal Title
Immunogenetics. 61(9)
Pages: 635-648
Related Report
Peer Reviewed
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[Journal Article] MHC class I A loci polymorphism and diversity in three Southeast Asian populations of cynomolgus macaque.2009
Author(s)
Kita YF, Hosomichi K, Kohara S, Itoh Y, Ogasawara K, Tsuchiya H, Torii R, Inoko H, Blancher A, Kulski .TK, Shiina T.
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Journal Title
Immunogenetics. 61
Pages: 635-648
Related Report
Peer Reviewed
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[Presentation] SNP association study of Behcet' s disease to unravel the genetic susceptibility and pathoetiology.2009
Author(s)
Kurata R, Nakaoka H, Tajima A, Saito T, Hosomichi K, Shiina T, Meguro A, Mizuki N, Inoko H, Inoue I
Organizer
The American Society of Human Genetics 59th Annual Meeting
Place of Presentation
Hawaii Convention Center, Honolulu, Hawaii
Year and Date
2009-10-22
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