| Project/Area Number |
21710204
|
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied genomics
|
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| Research Institution | National Institute of Genetics (2010)
Tokai University (2009) |
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Principal Investigator |
HOSOMICHI Kazuyoshi National Institute of Genetics, 総合遺伝研究系, 助教 (50420948)
|
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
|
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| Keywords | ニワトリ / MHC / ゲノム / 多様性 / SNP / トリインフルエンザ |
|---|
| Research Abstract |
The chicken MHC (MHC-B) is one of the research interests because of the strong associations with avian influenza virus infection identified in particular MHC-B haplotypes. Because sequence data of MHC-B haplotypes have been lacking, efforts to systematically resolve which genes within the MHC-B region contribute to well-defined MHC-B-associated disease responses was hampering. To indetify the genetic factor against influenza virus infection in the MHC-B region, we determined the complete genomic sequence of 2 MHC-B haplotypes across a region of 220kb encompassing 34 gene loci ranging from KIFC1 to C4.
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