Detection of genome rearrangement through genome comparison

• Project/Area Number: 21710209
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: ゲノム情報科学
• Research Institution: Japan Agency for Marine-Earth Science and Technology (2010); National Institute for Basic Biology (2009)
• Principal Investigator: KAWAI Mikihiko Japan Agency for Marine-Earth Science and Technology, 海洋・極限環境生物圏領域, ポストドクトラル研究員 (80451904)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 機能予測 / ゲノム多型 / ゲノム進化 / ゲノム比較 / 系統プロファイル / 機能推定 / ゲノム多型検索 / 系統プロファイル法 / 代謝経路 / 酸化還元 / 制限酵素 / 遺伝子の水平移動 / メタゲノム / 有用遺伝子

Research Abstract

Homology-based methods widely used to infer a function of a gene cannot be applied to genes lacking any detectable homology with functionally or structurally characterized genes. In the present study with the aim of identifying such genes, we developed a method that does not stand on homology of a gene but instead stands on homology of its surrounding nucleotide sequences.

Research Products

• [Presentation] Phylogenetic Profiling Based on Gene Property : Identification of Decaying Pathways in a Subset of Closely Related Organisms. (2011)
  • Author(s): Mikihiko Kawai
  • Organizer: APBC2011 The 9th Asia Pacific Bioinformatics Conference.
  • Place of Presentation: Songdo Convensia, Incheon, Korea
• [Presentation] Phylogenetic Profiling Based on Gene Property : Identification of Decaying Pathways in a Subset of Closely Related Organisms (2011)
  • Author(s): Kawai, Mikihiko
  • Organizer: APBC2011 The 9th Asia Pacific Bioinformatics Conference
  • Place of Presentation: Songdo Convensia, Incheon, Korea
• [Presentation] Phylogenetic Profiling Based on Gene Properties : Identifying Gene Families with Characteristic Distribution among Closely Related Organisms. (2010)
  • Author(s): Mikihiko Kawai
  • Organizer: Asian Young Researchers Conference on Computational and Omics Biology AYRCOB 2010
  • Place of Presentation: National Cheng Kung University, Taiwan
• [Presentation] ゲノム比較インフォマティクスによるゲノム進化の方向性の解明 (2009)
  • Author(s): 河合幹彦
  • Organizer: ゲノム微生物学会若手の会
  • Place of Presentation: 東京・八王子セミナーハウス
  • Year and Date: 2009-11-19