Development of cancer diagnosis method and investigation of therapeutic target by using Bioinformatics

• Project/Area Number: 21710211
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: ゲノム情報科学
• Research Institution: Chubu University
• Principal Investigator: TAKAHASHI Hiro Chubu University, 応用生物学部, 講師 (30454367)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 医療・福祉 / バイオマーカー / 癌 / 細胞・組織 / バイオテクノロジー

Research Abstract

In the present study, we developed new bioinformatics method on the basis of two methods, genetic algorithm and permutation test, and we investigated new candidates of anticancer drugs for therapeutic targets extracted by bioinformatics.

Research Products

• [Journal Article] Forkhead box A1 transcriptional pathway in KRT7-expressing esophageal squamous cell carcinomas with extensive lymph node metastasis (2010)
  • Author(s): Sano, M.Aoyagi, K.Takahashi, H.Kawamura, T.Mabuchi, T.Igaki, H.Tachimori, Y.Kato, H.Ochiai, A.Honda, H.Nimura, Y.Nagino, M.Yoshida, T.Sasaki, H.
  • Journal Title: Int.J.Oncol. 36(2) Pages: 321-330
  • Peer Reviewed
• [Journal Article] Forkhead box A1 transcriptional pathway in KRT7-expressing esophageal squamous cell carcinomas with extensive lymph node metastasis (2010)
  • Author(s): M.Sano
  • Journal Title: Int.J.Oncol. 36 Pages: 321-330
  • Peer Reviewed
• [Journal Article] Identification of ENHANCER OF SHOOT REGENERATION 1-upregulated genes during in vitro shoot regeneration (2009)
  • Author(s): Matsuo, N.Mase, H.Makino, M.Takahashi, H.Banno, H.
  • Journal Title: Plant Biotechnol. 26(4) Pages: 385-393
  • NAID: 10026136124
  • Peer Reviewed
• [Journal Article] Identification of ENHANCER OF SHOOT REGENERATION 1-upregulated genes during in vitro shoot regeneration (2009)
  • Author(s): N.Matsuo
  • Journal Title: Plant Biotechnol. 26 Pages: 385-393
  • Peer Reviewed
• [Presentation] 遺伝子セット抽出評価のための遺伝的アルゴリズムと並び替え検定を使用した手法の開発 (2011)
  • Author(s): 丸井誠堂
  • Organizer: 第76回化学工学会年会
  • Place of Presentation: 東京農工大学(東京)
  • Year and Date: 2011-03-23
• [Presentation] 遺伝子セット抽出評価のための遺伝的アルゴリズムと並び替え検定を使用した手法の開発 (2011)
  • Author(s): 丸井誠堂・小塩高広・高橋広夫・小林猛
  • Organizer: 第76回化学工学会年会(震災により開催中止、発表は成立)
  • Place of Presentation: 東京農工大学
• [Presentation] Analysis of alternative splicing mechanism regulated by an Arabidopsis ASF/SF2-like serine/arginine-rich protein, atSR30, in response to high-light stress (2010)
  • Author(s): 横山国大
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド(神戸)
  • Year and Date: 2010-12-07
• [Presentation] Identification of genes whose alternative splicing events are regulated by an Arabidopsis serine/arginine-rich-related protein, atSR45a, in response to high-light stress using a tiling microarray. (2010)
  • Author(s): 森達也
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド(神戸)
  • Year and Date: 2010-12-07
• [Presentation] Identification of genes whose alternative splicing events are regulated by an Arabidopsis serine/arginine-rich-related protein, atSR45a, in response to high-light stress using a tiling microarray (2010)
  • Author(s): 森達也・田部記章・丸田隆典・横山国大・佐藤信雄・高橋広夫・吉村和也・重岡成
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] Analysis of alternative splicing mechanism regulated by an Arabidopsis ASF/SF2-like serine/arginine-rich protein, atSR30, in response to high-light stress (2010)
  • Author(s): 横山国大・石川裕基・森達也・田部記章・丸田隆典・佐藤信雄・高橋広夫・吉村和也・重岡成
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] 食道扁平上皮がんの悪性度と相関するリンパ節転移のFOXA転写経路を介した新たな分子機構 (2009)
  • Author(s): 青柳一彦
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜パシフィコ(横浜)
  • Year and Date: 2009-10-03
• [Presentation] New simple and practical gene filtering approach, modified signal-to-noise filtering method (2009)
  • Author(s): H.Takahashi
  • Organizer: European Biomarkers Summit 2009
  • Place of Presentation: Barcelona, Spain
• [Presentation] 食道扁平上皮がんの悪性度と相関するリンパ節転移のFOXA転写経路を介した新たな分子機構 (2009)
  • Author(s): 青柳一彦・佐野正行・高橋広夫・馬渕智子・藤田剛・井垣弘康・日月裕司・本多裕之・落合淳志・吉田輝彦・佐々木博己
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] The AS2 regulates leaf polarity by repressing ETT/ARF3 in Arabidopsis. (2009)
  • Author(s): M.Iwasaki, H.Iwakawa, H.Takahashi, Y.Ueno, I.Pekker, Y.Eshed, S.Kojima, Y.Machida, C.Machida
  • Organizer: Auxins and Cytokinins in Plant Development-Third International Symposium.
  • Place of Presentation: Prague, Czech Republic
• [Presentation] Arabidopsis DNA contains very few putative G-quadruplex sequence motifs. (2009)
  • Author(s): A.Nakagawa, H.Takahashi, N.Sato, S.Kojima, B.-Y.Cha, J.-T.Woo, Y.Machida, C.Machida
  • Organizer: In Proceedings of the 20th International Conference on Arabidopsis Research
  • Place of Presentation: Edinburgh, the United Kingdom